The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1648-1651

  Jain, Harsh V ^a   Rasheed, Roshni ^a   Kalman, Thomas I ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Enzyme mechanism; Inhibition kinetics; Thymidine phosphorylase; Transition state analog

Indexed keywords

5 FLUORO 6 [(2 AMINOIMIDAZOL 1 YL)METHYL]URACIL; ARSENIC ACID; PHOSPHATE; THYMIDINE PHOSPHORYLASE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; ELECTRICITY; HYDROGEN BOND; KINETICS; SYNTHESIS;

CATALYSIS; CATALYTIC DOMAIN; ENZYME INHIBITORS; HYDROGEN BONDING; KINETICS; PHOSPHATES; PROTEIN BINDING; STATIC ELECTRICITY; THYMIDINE PHOSPHORYLASE; THYMINE;

EID: 76649116193     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.076     Document Type: Article

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