S1P receptor mediated activity of FTY720 phosphate mimics

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1485-1487

  Högenauer, Klemens ^a   Hinterding, Klaus ^a   Nussbaumer, Peter ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

FTY720; Phosphate mimic; S1P receptor agonist

Indexed keywords

AMINOALCOHOL; CARBOXYLIC ACID DERIVATIVE; FINGOLIMOD; HYDANTOIN DERIVATIVE; PHOSPHATE; PHOSPHONIC ACID DERIVATIVE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SULFONIC ACID DERIVATIVE; SULFONYLHYDANTOIN DERIVATIVE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHIRALITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; LYMPHOCYTE COUNT; NONHUMAN; RAT; RECEPTOR BINDING;

ADMINISTRATION, ORAL; AMINO ACIDS; ANIMALS; IMMUNOSUPPRESSIVE AGENTS; ISOLEUCINE; LYMPHOCYTES; PHOSPHATES; PHOSPHORYLATION; PROPYLENE GLYCOLS; RATS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE;

RATTUS;

EID: 76649114631     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.118     Document Type: Article

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22. 50 of ca. 10 mg/kg.