Adjuvant properties of AcF1, an immunostimulant fraction of alchornea cordifolia extract

Immunological Investigations

Volumn 39, Issue 2, 2010, Pages 132-158

  Nworu, C S ^a,b   Esimone, C O ^c   Tenbusch, M ^a   Nabi, G ^a   Proksch, P ^d   Berla, K ^a   Temchura, V V ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b UNIVERSITY OF NIGERIA   (Nigeria)

^c NNAMDI AZIKIWE UNIVERSITY   (Nigeria)

^d HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Adjuvants; Alchornea cordifolia; DCs maturation; Flavonoids; Immunostimulation; Lymphoproliferation

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACF1; ALCHORNEA CORDIFOLIA EXTRACT; CD69 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; BONE MARROW; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DENDRITIC CELL; DRUG ACTIVITY; DRUG STRUCTURE; EMBRYO; FEMALE; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOSTIMULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; STRUCTURE ACTIVITY RELATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; DENDRITIC CELLS; EUPHORBIACEAE; FEMALE; FLAVONOIDS; INTERFERON-GAMMA; INTERLEUKIN-4; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OVALBUMIN; PLANT EXTRACTS; SPLEEN;

EID: 76649104738     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820130903496793     Document Type: Article

References (43)

1. Akasaki, Y., Kikuchi, T., Homma, S., Abe, T., Kufe, D., Ohno, T. (2001). Antitumor effect of immunizations with fusions of dendritic and glioma cells in a mouse brain tumor model. J. Immunother. 24:106-113.
2. Allison, A. C., Byars, N. E. (1991). Immunological adjuvants: desirable properties and side effects. Mol. Immunol. 28:279-284.
3. Ayisi, N. K., Nyadedzor, C. (2003). Comparative in vitro effects of AZT and extracts of Ocimum gratissimum, Ficus polita, Clausena anisata, Alchornea cordifolia, and Elaeophorbia drupifera against HIV-1 and HIV-2 infections. Antiviral Res. 58:25-33.
4. Banchereau, J., Briere, F., Caux, C., Davoust, J., Lebecque, S., Liu, Y. J., Pulendran, B., Palucka, K. (2000). Immunobiology of dendritic cells. Annu Rev Immunol 18:767-811.
5. Banchereau, J., Steinman, R. M. (1998). Dendritic cells and the control of immunity. Nature 392:245-252.
6. Betts, M. R., Brenchley, J. M., Price, D. A., De Rosa, S. C., Douek, D. C., Roederer, M., Koup, R. A. (2003). Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J. Immunol. Meth. 281:65-78.
7. Bomford, R. (1989) Aluminium salts: perspectives in their use as adjuvants. In: Gregoriadis G, Allison AC, Poste G, editors. Immunological Adjuvants and Vaccines. New York: Plenum Press; p. 35-41.
8. Brewer, J. M., Conacher, M., Satoskar, A., Bluethmann, H., Alexander, J. (1996). In interleukin-4-deficient mice, alum not only generates T helper 1 responses equivalent to Freund's complete adjuvant, but continues to induce T helper 2 cytokine production. Eur. J. Immunol. 26:2062-2066.
9. Cooper, P. D. Steele, E. J. (1988). The adjuvanicity of g inulin. Immunol. Cell. Biol. 66 (Pt. 5-6):345-352.
10. Fleck, J. D., Kauffmann, C., Spilki, F., Claiton, L, Lencina, C. L., Roehe, P. M. Gosmann, G. (2006). Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice, Vaccine 24(49-50):7129-7134.
11. Gautam, M., Diwanay, S. S., Gairolam S., Shinde, Y. S., Jadhav, S. S., Patwardhan B. K. (2004). Immune response modulation to DPT vaccine by aqueous extract of Withania somnifera in experimental system. Int. Immunopharmacol. 4(6):841-849.
12. Glenny, A. T., Pope, C. G., Waddington, H., Wallace, V. (1926). The antigenic value of toxoid precipitated by potassium-alum. J. Path. Bacteriol. 29:38-45.
13. Goldenthal, K. L., Cavagnaro, J. A., Alving, C. R., Vogel, F. R. (1993). Safety evaluation of vaccine adjuvants. National Cooperative Vaccine Development Working Group. AIDS Res. Hum. Retroviruses 9:S45-S49.
14. Goto, N., Kato, H., Maeyama, J.-I., Eto, K., Yoshihara, S. (1993). Studies on the toxicities of aluminium hydroxide and calcium phosphate as immunological adjuvants for vaccines. Vaccine 11:914-918.
15. Gupta, R. K., Rost, B. E., Relyveld, E., Siber, G. R. (1995). Adjuvant properties of aluminium and calcium compounds. In: Powell MF, Newman MJ, editors. Vaccine Design: The Subunit and Adjuvant Approach. New York: Plenum Press; 229-248.
16. Igbeneghu, O. A., Iwalewa, E. O., Lamikanra, A. (2007). A study of the in vivo activity of the leaf extract of Alchornea cordifolia against multiply antibiotic resistant S-aureus isolate in mice. Phytother. Res. 21:67-71.
17. Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., Steinman, R. M. (1992). Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176:1693-1702.
18. Iwu, M. M. (1993). Handbook of African Medicinal Plants. CRC Press: Boca Raton, FL; 110-111.
19. Kambu, K. (1990). Elémént de Phytothérapie comparée, Plantes Médicinales Africaines. Centre de Recherches Pédagogiques, Kinshasa, p. 6-8.
20. Khajuria, A., Gupta, A., Singh, S., Malik, F., Singh, J., Suri, K. A., Satti, N. K., Qazi, G. N., Srinivas, V. K., Gopinathan, E. K. (2007). RLJ-NE-299A: A new plant based vaccine adjuvant. Vaccine 25(14):2706-2715.
21. Lamikanra, A., Ogundani, A. O., Ogungbamila, F. O. (1990). Antibacterial constituents of Alchornea cordifolia leaves. Phytother. Res. 4:198-200.
22. Lewis, T. S., Shapiro, P. S., Ahn, N. G. (1998). Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74:49-139.
23. Mavar-Manga, H., Chapon, D., Hoet, S., Block, S., De Pauw-Gillet, M. -C., Quetin Leclercq, J. (2006). N1,N2,N3-trisisopentenyl guanidine and N1,N2- diisopentenyl guanidine, two cytotoxic alkaloids from Alchornea cordifolia (Schumach.& Thonn.) Mull. Arg. (Euphorbiaceae) root barks. Nat. Prod. Commun. 1(12):1097-1100.
24. Mavar-Manga, H., Brkic, D., Marie, D. E. P., Quetin-Leclercq, J. (2004). In vivo antiinflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mill. Arg. (Euphorbiaceae). J. Ethnopharmacol. 92:209-214.
25. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Meth. 65(1-2):55-63.
26. Muanza, D. N., Euler, K. L., Williams, L., Newman, D. J. (1995). Screening for anti- tumour and anti-HIV activities of nine medicinal plants from Zaire. Int. J. Pharmacognosy 33:98-106.
27. Neuwinger, H. D. (2000). African Traditional Medicine-A Dictionary of Plant Use and Applications. Medpharm: Stuttgart, Germany; 29-30.
28. Nworu, C. S., Temchura V. T., Okoye, F. B. C., Akah, P. A., Esimone, C. O., Überla, K. (2009). Activation of murine lymphocytes and modulation of macrophage functions by fractions of Alchornea cordifolia (Euphorbiaceae) leaf extract. Immunopharmacol. Immunotoxicol. 2009, iFirst article (1-9), DOI: 10.1080/ 08923970903062587.
29. Nyakabwa, M., Diabaluka, M. (1990). Plantes médicinales cultivées dans la zone de Kabondo à Kisangani (Zaire). African Study Monographs 11:87-99.
30. Ogunlana, E. O., Ramstad, E. (1975). Investigations into the antibacterial activities of local plants. Planta Medica 27:354-360.
31. Pearson, G.; Robinson, F. Beers Gibson, T.; Xu, B. E.; Karandikar, M.; Berman, K.; Cobb, M.H. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22(2):153-183. Doi: 10.1210/er.22.2.153.
32. Petrovsky, N. (2006). Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity. Vaccine 24(Suppl. 2):S2-26-29
33. Petrovsky, N. (2008). Freeing vaccine adjuvants from dangerous immunological dogma. Expert Rev. Vaccines 7(1):7-10.
34. Petrovsky, N., Aguilar, J. C. (2004). Vaccine adjuvants: current state and future trends. Immunol. Cell Biol. 82:488-496.
35. Quan, F. S., Compans, R. W., Cho, Y. K., Kang, S. M. (2007). Ginseng and Salviae herbs play a role as immune activators and modulate immune responses during influenza virus infection. Vaccine 25:272-282.
36. Sakure, S., Negi, V. D., Mitra, S. K., Nandakumar K. S., Chakravortty, D. (2008). Vaccine with herbal adjuvant- A better cocktail to combat the infection Sandhya. Vaccine 26:3387-3388.
37. Schirmbeck, R., Melber, K., Mertens, T., Reimann, J. (1994). Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implications for the pathogenesis of HBV-induced hepatitis. J. Virol. 68:1418-1425.
38. Silva, D. G., Cooper, P. D., Petrovsky, N. (2004). Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses. Immunol. Cell Biol. 82(6):611-616
39. Stewart-Tull, D. E. S. (1989). Recommendations for the assessment of adjuvants. In: Gregoriadis, G., Allison, A. C., Poste, G. (eds). Immunological Adjuvants and Vaccines. New York: Plenum Press; p. 213-226.
40. Traquina, P., Morandi, M., Contorni, M., Van Nest, G. (1996). MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates. J. Infect. Dis. 174:1168-1175.
41. Vega, E. R. (2005). Vaccine adjuvants comprising ginseng plant extract and added aluminum salt. U.S. Patent No. 149119, Issued on June 14, 2005.
42. Yang, T., Jia, M., Meng, J., Wu, H., Mei, Q. (2006). Immunomodulatory activity of polysaccharide isolated from Angelica sinensis. Int. J. Biol. Macromol. 39(4-5): 179-184. (Pubitemid 44602203)
43. Ziegler, S. F., Ramsdell, F., Alderson, M. R. (1994). The activation antigen CD69. Stem Cells 12:456-465.