Cyclophosphamide reduces dectin-1 expression in the lungs of naive and Aspergillus fumigatus-infected mice

Medical Mycology

Volumn 48, Issue 2, 2010, Pages 303-309

  Yang, Jianxun ^a   Lu, Qiaoyun ^a   Liu, Wan ^a   Wan, Zhe ^a   Wang, Xiaohong ^a   Li, Ruoyu ^a  

^a PEKING UNIVERSITY   (China)

Author keywords

Aspergillus fumigatus; Cyclophosphamide; Dectin 1

Indexed keywords

CYCLOPHOSPHAMIDE; DECTIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; FUNGUS SPORE; HOST RESISTANCE; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IN VITRO STUDY; IN VIVO STUDY; INFECTION SENSITIVITY; LUNG ASPERGILLOSIS; LUNG PARENCHYMA; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ASPERGILLUS; ASPERGILLUS FUMIGATUS; FUNGI; MURINAE; MUS;

EID: 76649093282     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693780903136887     Document Type: Article

References (31)

1. Latge JP. Aspergillus fumigatus and aspergillosis. C lin Microbiol Rev. 1999; 12: 310-350 .
2. Soubani AO, Chandrasekar PH. The clinical spectrum of pulmonary aspergillosis. Chest 2002; 121: 1988-1999 .
3. Kontoyiannis DP, Bodey GP. Invasive aspergillosis in 2002: an update. Eur J Clin Microbiol Infect Dis 2002; 21: 161-172 .
4. Brown GD, Gordon S. Immune recognition of fungal beta-glucans. Cell Microbiol 2005; 7: 471-479 .
5. van de Veerdonk FL, Kullberg BJ, van der Meer JW, Gow NA, Netea MG. Host-microbe interactions: innate pattern recognition of fungal pathogens. Curr Opin Microbiol 2008; 11: 305-312 .
6. Suram S, Brown GD, Ghosh M, et al. Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor. J Biol Chem 2006; 281: 5506-5514 .
7. Brown GD, Gordon S. Immune recognition. A new receptor for betaglucans. Nature 2001; 413: 36-37 .
8. Brown GD. Dectin-1: a signalling non-TLR pattern-recognition receptor. Nat Rev Immunol 2006; 6: 33-43.
9. Ariizumi K, Shen GL, Shikano S, et al. Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem 2000; 275: 20157-20167 .
10. Taylor PR, Brown GD, Reid DM, e t al. The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J Immunol 2002; 169: 3876-3882 .
11. Herre J, Gordon S, Brown GD. Dectin-1 and its role in the recognition of beta-glucans by macrophages. Mol Immunol 2004; 40: 869-876 .
12. Kennedy AD, Willment JA, Dorward DW, et al. Dectin-1 promotes fungicidal activity of human neutrophils. Eur J Immunol 2007; 37: 467-478 .
13. Steele C, Rapaka RR, Metz A, et al. The beta-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus . PLoS Pathog 2005; 1: e42 .
14. Vallor AC, Kirkpatrick WR, Najvar LK, e t al. Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture. Antimicrob Agents Chemother 2008; 52: 2593-2598 .
15. Philippe B, Ibrahim-Granet O, Prevost MC, et al. Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infect Immun 2003; 71: 3034-3042 .
16. Balloy V, Huerre M, Latge JP, Chignard M. Differences in patterns of infection and Inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infect Immun 2005; 73: 494-503 .
17. Werner JL, Metz AE, Horn D, et al. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus . J Immunol 2009; 182: 4938-4946 .
18. Klis FM, Mol P, Hellingwerf K, Brul S. Dynamics of cell wall structure in Saccharomyces cerevisiae . FEMS Microbiol Rev 2002; 26: 239-256 .
19. Hohl TM, Van Epps HL, Rivera A, e t al. A spergillus fumigatus triggers Inflammatory responses by stage-specific beta-glucan display. PLoS Pathog 2005; 1: e30 .
20. Gantner BN, Simmons RM, Canavera SJ, Akira S, Underhill DM. Collaborative induction of Inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med 2003; 197: 1107-1117 .
21. Brown GD, Herre J, Williams DL, et al. Dectin-1 mediates the biological effects of beta-glucans. J Exp Med 2003; 197: 1119-1124 .
22. Luther K, Torosantucci A, Brakhage AA, Heesemann J, Ebel F. Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol 2007; 9: 368-381 .
23. Steele C, Marrero L, Swain S, et al. Alveolar macrophage-mediated killing of Pneumocystis carinii f. sp. muris involves molecular recognition by the Dectin-1 beta-glucan receptor. J Exp Med 2003; 1 98: 1677-1688.
24. Gantner BN, Simmons RM, Underhill DM. Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments. Embo J 2005; 24: 1277-1286 .
25. Viriyakosol S, Fierer J, Brown GD, Kirkland TN. Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Tolllike receptor 2 and Dectin-1. Infect Immun 2005; 73: 1553-1560 .
26. Hunninghake GW, Fauci AS. Immunological reactivity of the lung. IV. Effect of cyclophosphamide on alveolar macrophage cytotoxic effector function. Clin Exp Immunol 1977; 27: 555-559.
27. Cooper JA, Jr Merrill WW, Reynolds HY. Cyclophosphamide modulation of bronchoalveolar cellular populations and macrophage oxidative metabolism. Possible mechanisms of pulmonary pharmacotoxicity. Am Rev Respir Dis 1986; 134: 108-114.
28. Santosuosso M, Divangahi M, Zganiacz A, Xing Z. Reduced tissue macrophage population in the lung by anticancer agent cyclophosphamide: restoration by local granulocyte macrophage-colony-stimulating factor gene transfer. Blood 2002; 99: 1246-1252 .
29. Bellocchio S, Montagnoli C, Bozza S, et al. The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivo . J Immunol 2004; 172: 3059-3069 .
30. Mehrad B, Strieter RM, Standiford TJ. Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. J Immunol 1999; 162: 1633-1640 . (Pubitemid 29307039)
31. Willment JA, Lin HH, Reid DM, et al. Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharide. J Immunol 2003; 171: 4569-4573 .