Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain

Journal of Neuroscience Research

Volumn 88, Issue 4, 2010, Pages 798-806

  Shimada, Nobuko ^a   Handa, Setsuko ^a   Uchida, Yoshiaki ^b   Fukuda, Mitsugu ^a   Maruyama, Naoki ^a   Asaga, Hiroaki ^c   Choi, Eun Kyoung ^d   Lee, Jaewon ^e   Ishigami, Akihito ^a,f  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b FUJIREBIO INC   (Japan)

^c MEIJI UNIVERSITY   (Japan)

^d Hallym University   (South Korea)

^e Pusan National University   (South Korea)

^f TOHO UNIVERSITY   (Japan)

Author keywords

Cerebellum; Citrullination; Neurodegenerative disorder; PAD2; Purkinje cells

Indexed keywords

MESSENGER RNA; PROTEIN ARGININE DEIMINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGING; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; BRAIN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYDROLASES; MALE; MICE; MICE, INBRED C57BL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 76549127361     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22255     Document Type: Article

References (33)

1. Akiyama K, Sakurai Y, Asou H, Senshu T. 1999. Localization of peptidylarginine deiminase type II in a stage-specific immature oligodendrocyte from rat cerebral hemisphere. Neurosci Lett 274:53-55.
2. Asaga H, Ishigami A. 2000. Protein deimination in the rat brain: generation of citrulline-containing proteins in cerebrum perfused with oxygen-deprived media. Biomed Res 21:197-205.
3. Asaga H, Ishigami A. 2001. Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration. Neurosci Lett 299:5-8.
4. Asaga H, Senshu T. 1993. Combined biochemical and immunocytochemical analyses of postmortem protein deimination in the rat spinal cord. Cell Biol Int 17:525-532.
5. Asaga H, Yamada M, Senshu T. 1998. Selective deimination of vimentin in calcium ionophore-induced apoptosis of mouse peritoneal macrophages. Biochem Biophys Res Commun 243:641-646.
6. Asaga H, Akiyama K, Ohsawa T, Ishigami A. 2002. Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain. Neurosci Lett 326:129-132.
7. Balcarek JM, Cowan NJ. 1985. Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family. Nucleic Acids Res 13:5527-5543.
8. Cheron G, Servais L, Dan B. 2008. Cerebellar network plasticity: from genes to fast oscillation. Neuroscience 153:1-19.
9. Erickson MA, Haburcak M, Smukler L, Dunlap K. 2007. Altered functional expression of Purkinje cell calcium channels precedes motor dysfunction in tottering mice. Neuroscience 150:547-555.
10. 2+-dependent deimination-induced disassembly of intermediate filaments involves specific modification of the amino-terminal head domain. J Biol Chem 264:18119-18127.
11. Ishigami A, Asaga H, Ohsawa T, Akiyama K, Maruyama N. 2001. Peptidylarginine deiminase type I, type II, type III and type IV are expressed in rat epidermis. Biomed Res 22:63-65.
12. Ishigami A, Ohsawa T, Asaga H, Akiyama K, Kuramoto M, Maruyama N. 2002. Human peptidylarginine deiminase type II: molecular cloning, gene organization, and expression in human skin. Arch Biochem Biophys 407:25-31.
13. Ishigami A, Ohsawa T, Hiratsuka M, Taguchi H, Kobayashi S, Saito Y, Murayama S, Asaga H, Toda T, Kimura N, Maruyama N. 2005. Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease. J Neurosci Res 80:120-128.
14. Jang B, Kim E, Choi JK, Jin JK, Kim JI, Ishigami A, Maruyama N, Carp RI, Kim YS, Choi EK. 2008. Accumulation of citrullinated proteins by up-regulated peptidylarginine deiminase 2 in brains of scrapie-infected mice: a possible role in pathogenesis. Am J Pathol 173:1129-1142.
15. Keilhoff G, Prell T, Langnaese K, Mawrin C, Simon M, Fansa H, Nicholas AP. 2008. Expression pattern of peptidylarginine deiminase in rat and human Schwann cells. Dev Neurobiol 68:101-114.
16. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
17. Lewis SA, Wang DH, Cowan NJ. 1988. Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein. Science 242:936-939.
18. Mastronardi FG, Wood DD, Mei J, Raijmakers R, Tseveleki V, Dosch HM, Probert L, Casaccia-Bonnefil P, Moscarello MA. 2006. Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation. J Neurosci 26:11387-11396.
19. 2+ channel mutant mice. J Neurosci 22:4388-4398.
20. Moscarello MA, Wood DD, Ackerley C, Boulias C. 1994. Myelin in multiple sclerosis is developmentally immature. J Clin Invest 94:146-154.
21. Moscarello MA, Mastronardi FG, Wood DD. 2007. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis. Neurochem Res 32:251-256.
22. Musse AA, Li Z, Ackerley CA, Bienzle D, Lei H, Poma R, Harauz G, Moscarello MA, Mastronardi FG. 2008. Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Model Mech 1:229-240.
23. 3. J Biol Chem 274:27786-27792.
24. Senshu T, Sato T, Inoue T, Akiyama K, Asaga H. 1992. Detection of citrulline residues in deiminated proteins on polyvinylidene difluoride membrane. Anal Biochem 203:94-100.
25. Servais L, Bearzatto B, Schwaller B, Dumont M, De Saedeleer C, Dan B, Barski JJ, Schiffmann SN, Cheron G. 2005. Mono- and dual-frequency fast cerebellar oscillation in mice lacking parvalbumin and/or calbindin D-28k. Eur J Neurosci 22:861-870.
26. Tarcsa E, Marekov LN, Mei G, Melino G, Lee SC, Steinert PM. 1996. Protein unfolding by peptidylarginine deiminase. Substrate specificity and structural relationships of the natural substrates trichohyalin and filaggrin. J Biol Chem 271:30709-30716.
27. Towbin H, Staehelin T, Gordon J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76:4350-4354.
28. Tso JY, Sun XH, Kao TH, Reece KS, Wu R. 1985. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res 13:2485-2502.
29. Vossenaar ER, Zendman AJ, van Venrooij WJ, Pruijn GJ. 2003. PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease. Bioessays 25:1106-1118.
30. Watanabe K, Senshu T. 1989. Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase. J Biol Chem 264:15255-15260.
31. Watanabe K, Akiyama K, Hikichi K, Ohtsuka R, Okuyama A, Senshu T. 1988. Combined biochemical and immunochemical comparison of peptidylarginine deiminases present in various tissues. Biochim Biophys Acta 966:375-383.
32. Whitney ER, Kemper TL, Bauman ML, Rosene DL, Blatt GJ. 2008. Cerebellar Purkinje cells are reduced in a subpopulation of autistic brains: a stereological experiment using calbindin-D28k. Cerebellum 7:406-416.
33. Wood DD, Ackerley CA, Brand B, Zhang L, Raijmakers R, Mastronardi FG, Moscarello MA. 2008. Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities. Lab Invest 88:354-364.