In vitro antioxidant and in vivo prophylactic effects of two γ-lactones isolated from Grewia tiliaefolia against hepatotoxicity in carbon tetrachloride intoxicated rats

European Journal of Pharmacology

Volumn 631, Issue 1-3, 2010, Pages 42-52

  Khadeer Ahamed, Mohamed B ^a   Krishna, Venkatarangaiah ^b   Dandin, Chethan J ^c  

^a UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

^b KUVEMPU UNIVERSITY   (India)

^c INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Antioxidant activity; D erythro 2 hexenoic acid lactone; Grewia tiliaefolia; Gulonic acid lactone; Hepatoprotective activity

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; DEXTRO ERYTHRO 2 HEXENOIC ACID GAMMA LACTONE; GAMMA LACTONE DERIVATIVE; GLUTATHIONE; GREWIA TILIAFOLIA EXTRACT; GULONIC ACID GAMMA LACTONE; LIVER PROTECTIVE AGENT; METHANOL; PLANT EXTRACT; SILYMARIN; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BARK; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; FEMALE; GREWIA; GREWIA TILIAFOLIA; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FEMALE; GLUCONATES; GREWIA; HEXANOIC ACIDS; LACTONES; LETHAL DOSE 50; LIPID PEROXIDATION; MALE; MEDICINE, TRADITIONAL; MOLECULAR STRUCTURE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT BARK; PLANT EXTRACTS; PLANT STEMS; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 76549118180     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.12.034     Document Type: Article

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