In vivo wound healing activity of the methanolic extract and its isolated constituent, gulonic acid γ-lactone, obtained from Grewia tiliaefolia

Planta Medica

Volumn 75, Issue 5, 2009, Pages 478-482

  Ahamed, B Mohamed Khadeer ^a   Krishna, Venkatarangaiah ^b   Malleshappa, Kumaraswamy H ^b  

^a Basaveshwara Medical College & Hospital   (India)

^b KUVEMPU UNIVERSITY   (India)

Author keywords

Grewia tiliaefolia; Gulonic acid lactone; Nitrofurazone; Skin breaking strength; Tiliaceae; Wound models

Indexed keywords

GREWIA TILIAEFOLIA EXTRACT; GULONIC ACID GAMMA LACTONE; HYDROXYPROLINE; METHANOL; NITROFURAL; PLANT EXTRACT; POLYSORBATE 80; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BARK; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG FORMULATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; EPITHELIZATION; FEMALE; GRANULATION TISSUE; GREWIA TILIAEFOLIA; HISTOPATHOLOGY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OINTMENT; RAT; SKIN INJURY; TENSILE STRENGTH; TILIACEAE; WOUND CONTRACTION; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GRANULATION TISSUE; GREWIA; LACTONES; MALE; NITROFURAZONE; OINTMENTS; PLANT BARK; PLANT EXTRACTS; PLANT STEMS; RATS; RATS, WISTAR; SKIN; SUGAR ACIDS; TENSILE STRENGTH; WOUND HEALING;

ANIMALIA; GREWIA; MALVACEAE; RATTUS NORVEGICUS;

EID: 68949118394     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185315     Document Type: Article

References (26)

1. Juvekar AR, Sakat SS, Shah AS, Wakade AS. Anti-inflammatory activity of an aqueous extract of Grewia tiliaefolia leaves. Planta Med 2007; 73: 825
2. Kirthikar KR, Basu BD. Grewia tiliaefolia Vahl. Indian medicinal plants. India: Allahabad Press; 1975: 387
3. Anjaneyulu B, Rao VB, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN. Chemical investigation of some plants. Indian J Chem 1965; 3: 237
4. Badami S, Mahesh KG, Noble M, Subramania NM, Bhojraj S, David JB. HPTLC determination of lupeol in Grewia tiliaefolia. J Planar Chromatogr 2002; 15: 183-186 (Pubitemid 34885104)
5. Badami S, Gupta MK, Ramaswamy S, Rai SR, Nanjaian M, Bendell DJ, Subban R, Bhojaraj S. Determination of betulin in Grewia tiliaefolia by HPTLC. J Sep Sci 2004; 27: 129-131 (Pubitemid 38190200)
6. Badami S, Vijayan P, Mathew N, Chandrashekhar R, Godavarthi A, Dhanaraj SA, Suresh B. In vitro cytotoxic properties of Grewia tiliaefolia bark and lupeol. Indian J Pharmacol 2003; 35: 250-251
7. Manjunatha BK, Krishna V, Pullaiah T. Floristic composition of Davanagere District, Karnataka, India. New Delhi: Regency Publications; 2004: 70
8. Jalalpure SS, Patil MB, Prakash NS, Hemalata K, Manvi FV. Hepatoprotective activity of fruits of Piper longum Linn. Indian J Pharm Sci 2003; 65: 363-366
9. Mukherjee PK. Quality control herbal drugs. New Delhi: Business Horizons; 2002
10. Morton JJ, Malone MH. Evaluation of vulnerary activity by an open wound procedure in rats. Arch Int Pharmacodyn Ther 1972; 196: 117-126
11. Diwan PV, Tilloo LD, Kulkarni DR. Influence of Tridax procumbens on wound healing. Indian J Med Res 1982; 75: 460-464 (Pubitemid 12060114)
12. Patil PA, Kulkarni DR. Antiproliferative agents on healing of dead space wounds in rats. Indian J Med Res 1984; 79: 445-447
13. Ehrlich HP, Hunt TK. The effects of cortisone and anabolic steroids on the tensile strength of healing wound. J Ann Surg 1969; 170: 203-206
14. Lee KH, Tong TG. Study on the mechanism of action of salicylates, retardation of wound healing by aspirin. J Pharm Sci 1968; 57: 1042-1043
15. D'Arcy PF, Howard EM, Muggleton PW, Townsend SB. The anti-inflammatory action of griseofulvin in experimental animals. J Pharm Pharmacol 1960; 12: 659-665
16. Dipasquale G, Meli A. Effect of bodyweight changes on the formation of cotton pellet induced granuloma. J Pharm Pharmacol 1965; 17: 379-382
17. Neuman RE, Logan MA. The determination of hydroxyproline. J Biol Chem 1950; 184: 299-306
18. Galigher AE, Kayloff EN. Essential of practical microtechnique. Philadelphia: Lea and Febiger; 1971: 77
19. Azad S. Essentials of surgery. Hyderabad, India: Paras Medical Publications; 2002: 1
20. Kumar R, Katoch SS, Sharma S. β-Adrenoceptor agonist treatment reverses denervation atrophy with augmentation of collagen proliferation in denervated mice gastrocnemius muscle. Indian J Exp Biol 2006; 44: 371-376
21. Khadeer Ahamed BM. Phytochemical and Pharmacological Screening of Grewia tiliaefolia Vahl. [dissertation]. India: Kuvempu University; 2007
22. Shirwaikar A, Shenoy R, Udupa AL, Udupa SL, Shetty S. Wound healing activity of phenolic extract of leaves of Hyptis suaveolens with supportive role of antioxidant enzymes. Indian J Exp Biol Med 2003; 41: 238-241 (Pubitemid 36290107)
23. Olas B, Saluk-Juszczak J, Nowak P, Glowacki R, Bald E, Wachowicz B. Protective effects of D-glucaro 1, 4-lactone against oxidative/nitrative modifications of plasma proteins. Nutrition 2007; 23: 164-171 (Pubitemid 46096724)
24. Aliaga C, Stuart DR, Aspée A, Scaiano JC. Solvent effects on hydrogen abstraction reactions from lactones with antioxidant properties. Org Lett 2005; 7: 3665-3668 (Pubitemid 41224545)
25. Scortichini M, Pia RM. Preliminary in vitro evaluation of the antimicrobial activity of terpenes and terpenoids towards Erwinia amylovora (Burrill). J Appl Bacteriol 1991; 71: 109-112
26. Getie M, Gebre MT, Reitz R, Neubert RH. Evaluation of the release profiles of flavonoids from topical formulations of the crude extract of the leaves of Dodonea viscosa (Sapindaceae). Pharmazie 2002; 57: 320-322 (Pubitemid 34517301