Clinical and bioavailability studies of sublingually administered atropine sulfate

American Journal of Emergency Medicine

Volumn 28, Issue 2, 2010, Pages 143-150

  Rajpal, Sheetal ^b   Ali, Raisuddin ^a   Bhatnagar, Aseem ^a   Bhandari, Sujit Kumar ^a   Mittal, Gaurav ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b DELHI INSTITUTE OF PHARMACEUTICAL SCIENCES AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; PENTETATE TECHNETIUM TC 99M;

ADULT; ARTICLE; BLOOD PRESSURE MONITORING; BLURRED VISION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; GAMMA SCINTIGRAPHY; HEART RATE; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; MALE; MYDRIASIS; NORMAL HUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PUPIL; SIDE EFFECT; SINGLE DRUG DOSE; SYSTOLIC BLOOD PRESSURE; THIRST; XEROSTOMIA;

ADMINISTRATION, SUBLINGUAL; ADULT; ANTIDOTES; ATROPINE; BIOLOGICAL AVAILABILITY; BIOTERRORISM; HUMANS; INJECTIONS; MALE; MUSCARINIC ANTAGONISTS; ORGANOPHOSPHORUS COMPOUNDS; PESTICIDES;

EID: 76549109762     PISSN: 07356757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajem.2008.10.025     Document Type: Article

References (30)

1. Eddleston M., Buckley N.A., Eyer P., and Dawson A.H. Management of acute organophosphorus pesticide poisoning. Lancet 371 (2008) 597-607
2. Ecobichon D.J. Toxic effects of pesticides. In: Klaassen C.D. (Ed). Toxicology (2001), McGraw-Hill, New York 763-768
3. Eddleston M., Karalliedde L., Buckley N., Fernando R., Hutchinson G., Isbister G., et al. Pesticide poisoning in the developing world-a minimum pesticides list. Lancet 360 (2002) 1163-1167
4. Reutter S. Hazards of chemical weapons released during war: new perspectives. Environ Health Perspect 107 (1999) 985-990
5. Newmark J. Nerve agents: pathophysiology and treatment of poisoning. Semin Neurol 24 (2004) 185-196
6. Marrs T.C., Rice P., and Vale J.A. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev 25 (2006) 297-323
7. Bajgar J. Organophosphates nerve agents poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv Clin Chem 38 (2004) 151-216
8. Pope C., Karanth S., and Liu J. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of common mechanism of action. Environ Toxicol Pharmacol 19 (2005) 433-446
9. Albuquerque E.X., Pereira E.F., Aracava Y., Fawcett W.P., Oliveira M., Randall W.R., et al. Effective countermeasure against poisoning by organophosphorus insecticides and nerve agents. Proc Natl Acad Sci U S A 103 (2006) 13220-13225
10. Sidell F. Nerve agents. In: Sidell F.R., Takafuji E.T., and Franz D.R. (Eds). Medical aspects of chemical and biological warfare (1997), Borden Institute, Washington 129-179
11. Dunn M.A., Hackley B.E., and Sidell F.R. Pretreatment for nerve agent exposure. In: Sidell F.R., Takafuji E.T., and Franz D.R. (Eds). Medical aspects of chemical and biological warfare (1997), Borden Institute, Washington 181-196
12. Bentur Y., Layish I., Krivoy A., Berkovitch M., Rotman E., Bar Haim S., et al. Civilian adult self injections of atropine-trimedoxime (TMB4) auto-injectors. Clin Toxicol 44 (2006) 301-306
13. Kehe C.R., Lasseter K.C., Miller N.C., Wick K.A., Shamblen E.C., Ekholm B.P., et al. Comparative absorption of atropine from a metered dose inhaler and an intramuscular injection. Ther Drug Monit 14 (1992) 132-134
14. Gervais H.W., el Gindi M., Radermacher P.R., Volz-Zang C., Palm D., Duda D., et al. Plasma concentration following oral and intramuscular atropine in children and their clinical effects. Paediatr Anaesth 7 (1997) 13-18
15. Berghem L., Bergman U., Schildt B., and Sörbo B. Plasma atropine concentrations determined by radioimmunoassay after single-dose i.v. and i.m. administration. Br J Anaesth 52 (1980) 597-601
16. Reisfield G.M., and Wilson G.R. Rational use of sublingual opioids in palliative medicine. J Palliat Med 10 (2007) 465-475
17. Batke-Hastings S., and Carman T.L. Sublingual administration of warfarin: a novel form of delivery. Vasc Med 13 (2008) 123-126
18. Volans A.P. Sarin: guidelines on the management of victims of a nerve gas attack. J Accid Emerg Med 13 (1996) 202-206
19. Kelly K., O'Mahony B., Lindsay B., Jones T., Grattan T.J., Rostami-Hodjegan A., et al. Comparison of the rates of disintegration, gastric emptying, and drug absorption following administration of a new and a conventional paracetamol formulation, using gamma scintigraphy. Pharm Res 20 (2003) 1668-1673
20. Davis J., Burton J., Connor A.L., Macrae R., and Wilding I.R. Scintigraphic study to investigate the effect of food on a HPMC modified release formulation of UK-294,315. J Pharm Sci (2008) [Electronic publication ahead of print]
21. Song J.H., Nguyen H.H., Cuburu N., Horimoto T., Ko S.Y., Park S.H., et al. Sublingual vaccination with influenza virus protects mice against lethal viral infection. Proct Natl Acad Sci U S A 105 (2008) 1644-1649
22. Volz-Zang C., Waldhäuser T., Schulte B., and Palm D. Comparison of the effects of atropine in vivo and ex vivo (radioreceptor assay) after oral and intramuscular administration to man. Eur J Clin Pharmacol 49 (1995) 45-49
23. Chan V.O., Colville J., Persaud T., Buckley O., Hamilton S., and Torreggiani W.C. Intramuscular injections into the buttocks: are they truly intramuscular?. Eur J Radiol 58 (2006) 480-484
24. Burbridge B.E. Computed tomographic measurement of gluteal subcutaneous fat thickness in reference to failure of gluteal intramuscular injections. Can Assoc Radiol J 58 (2007) 72-75
25. Nuhoglu Y., Ozumut S.S., Ozdemir C., Ozdemir M., Nuhoglu C., and Erguven M. Sublingual immunotherapy to house dust mite in pediatric patients with allergic rhinitis and asthma: a retrospective analysis of clinical course over a 3-year follow-up period. J Investig Allergol Clin Immunol 17 (2007) 375-378
26. Penagos M., Passalacqua G., Compalati E., Baena-Cagnani C.E., Orozco S., Pedroza A., et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest 133 (2008) 599-609
27. In: O'Neil M.J., Smith A., and Heckelman P.E. (Eds). The Merck Index, an encyclopedia of chemicals, drugs and biologicals. 13th Ed (2001), Merck and Co. INC, Whitehouse Station, NJ (USA) 151
28. Davis S.S., Hardy J.G., Newman S.P., and Wilding I.R. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nucl Med 19 (1992) 971-986
29. Wilding I.R., Coupe A.J., and Davis S.S. The role of gamma-scintigraphy in oral drug delivery. Adv Drug Deliv Rev 46 (2001) 103-124
30. Singh A.K., Bhardwaj N., and Bhatnagar A. Pharmacoscintigraphy: an unexplored modality in India. Ind J Pharm Sci 66 (2004) 18-25