A mutation in the first intracellular loop of CACNA1A prevents P/Q channel modulation by SNARE proteins and lowers exocytosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 4, 2010, Pages 1672-1677

  Serra, Selma A ^a   Cuenca León, Ester ^b   Llobet, Artur ^c   Rubio Moscardo, Francisca ^a   Plata, Cristina ^a   Carreño, Oriel ^d   Fernàndez Castillo, Noèlia ^d   Corominas, Roser ^b,d   Valverde, Miguel A ^a   Macaya, Alfons ^b   Cormand, Bru ^d   Fernández Fernández, José M ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Cav 2.1 (P Q) channels; Migraine with aura; SNARE proteins

Indexed keywords

CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; MUTANT PROTEIN; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN 1A;

ARTICLE; CLINICAL ARTICLE; EXOCYTOSIS; FAMILIAL HEMIPLEGIC MIGRAINE; FEMALE; HUMAN; HUMAN CELL; MALE; MIGRAINE WITH AURA; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ANIMALS; CALCIUM CHANNELS, N-TYPE; CELL LINE; CELL MEMBRANE; EXOCYTOSIS; FEMALE; HUMANS; INTRACELLULAR SPACE; MALE; MIGRAINE DISORDERS; MUTATION; PEDIGREE; RABBITS; RATS; SPAIN; SYNAPTOSOMAL-ASSOCIATED PROTEIN 25; SYNTAXIN 1;

EID: 76549092525     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908359107     Document Type: Article

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