Molecular validation of pain targets

Pain: Current Understanding, Emerging Therapies, and Novel Approaches to Drug Discovery

Volumn , Issue , 2003, Pages 355-364

  Tate, Simon ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 76549092346     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (83)

1. Lanteri-Minet M, De Pommery J, Herdegen T, Weil-Fugazza J, Bravo R, Menetrey D. Differential time course and spatial expression of Fos, Jun and Krox-24 proteins in spinal cord in rats undergoing subacute or chronic somatic inflammation. J Comp Neurol 1993; 333:223-235.
2. Hunt SP, Pini A, Evan G. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation. Nature 1987; 328:632-634.
3. Kieffer BL, Befort K, Gaveriaux-Ruff C, Hirth CG. The delta-opioid receptor: isolation of a cDNA by expression cloning and pharmacological characterization. Proc Natl Acad Sci USA 1992; 89: 12048-12052.
4. Evans CJ, Keith DE Jr, Morrison H, Magendzo K, Edwards RH. Cloning of a delta opioid receptor by functional expression. Science 1992; 258:1952-1955.
5. Chen Y, Mestek A, Liu J, Hurley JA, Yu L. Molecular cloning and functional expression of a muopioid receptor from rat brain. Mol Pharmacol 1993; 44:8-12.
6. Yasuda K, Raynor K, Kong H, Breder CD, Takeda J, Reisine T, Bell GI. Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci USA 1993; 90:6736-6740.
7. Raynor K, Kong H, Chen Y, Yasuda K, Yu L, Bell GI, Reisine T. Pharmacological characterization of the cloned κ-, δ-and Il-opioid receptors. Mol Pharmacol 1993; 45:330-334.
8. Reisine T, Bell GI. Molecular biology of opioid receptors. Trends Neurosci 1993; 16:506-510.
9. Munro S, Thoma KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993; 365:61-65.
10. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI. Structure of a cannabinoid receptor and functional expression of the cloned eDNA. Nature 1990; 346:561-564.
11. 2 bradykinin receptor. Proc Natl Acad Sci USA 1991; 88: 7724-7728.
12. 1 bradykinin receptor. J Bioi Chern 1994; 269:21583-21586.
13. Denyer J, Gray J, Wong M, Stolz M, Tate S. Molecular and pharmacological characterization of the human CCK-B receptor. Eur J Pharmacol 1994; 268:29-41.
14. Shelton DL, Sutherland J, Gripp J, Camerato T, Arrnanini MP, Phillips HS, Carroll K, Spencer SD, Levinson AD. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. Neuroscience 1995; 15:477-491.
15. Zukin RS, Bennett MVL. Alternatively spliced isoforms of the NMDARl receptor subunit. Trends Neurosci 1995; 18:306-313.
16. Yang N. George AL, Hom R. Molecular basis of charge movement in voltage-gated sodium channels. Neuron 1996; 16:113-122.
17. Tallent M, Dichter MA, Reisine T. Differential regulation of the cloned kappa and mu opioid receptors. Neuroscience 1998; 85:873-885.
18. Mansour A, Fox CA, Akil H, Watson SJ. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci 1995; 18:22-29.
19. Fraser GL, Wahlestedt C. Antisense approaches in the study of pain. Mol Neurobiol pain. Progr Pain Res Manage 1997; 9:319-336.
20. Mogil JS, Grisel JE. Transgenic studies of pain. Pain 1998; 77:107-128.
21. DeWitt DL. Prostaglandin endoperoxide synthase: regulation of enzyme expression. Biochim Biophys Acta 1991; 1083:121-134.
22. Kujubu DA, Fletcher BS, Varnum BC, Lim RW. Herschman HR. TISI0, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Bioi Chern 1992; 266:12866-12872.
23. Ryseck RP, Raynoschek C, Macdonald-Bravo H, Dorfman K, Mattei MG, Bravo R. Identification of an immediate early gene, pghs-b. whose protein product has prostaglandin synthase/cyclooxygenase activity. Cell Growth Differ 1992; 3:443-450.
24. Yokoyama C, Tanabe T. Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys Res Commun 1989; 165:888-894.
25. Hla T, Farrell M, Kumar A, Bailey JM. Isolation of the cDNA for human prostaglandin H synthase. Prostaglandins 1986; 32:829-845.
26. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 1991; 5:2304-2312.
27. Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci USA 1992; 89:7384-7388.
28. Hla T, Ristimaki A, Appleby S. Barriocanl JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Ann N Y Acad Sci 1993; 696:197-204.
29. Pritchard KA, O’Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB. Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo. J Bioi Chern 1994; 269:8504-8509.
30. Hemel SL, Monick MM, Hunninghake GW. Lipopolysaccharide induces prostaglandin H synthase2 protein and mRNA in human alveolar macrophages and blood monocytes. J Clin Invest 1994; 93: 391-396.
31. O’Sullivan MG, Huggins EM, Meade EA, DeWitt DL, McCall CE. Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages. Biochem Biophys Res Commun 1992; 187(2): 1123-1127.
32. Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D, Hwang D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Bioi Chern 1992; 267(6):25934-25938.
33. Schnabel J. Alzheimer’s disease: arthritis of the brain? New Sci 1993; 138:22-26.
34. Sano H, Kawahito Y, Wilder RL, Hashiramoto A, Mukai S, Asai K, Kimura S, Kato H, Kondo M, Hla T. Expression of cyclooxygenase-1 and -2 in human co1orectal cancer. Cancer Res 1995; 55: 3785-3789.
35. Reed DW, Bradshaw WS, Xie W, Simmons DL. In vivo and in vitro expression of a non-mammalian cyclooxygenase-1. Prostaglandins 1996; 52:269-284.
36. DeWitt DL, Smith WL. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc Natl Acad Sci USA 1988; 85:1412-1416.
37. Zhang V, O’Sullivan M, Hussain H, Roswit WT, Holtzman MJ. Molecular cloning, functional expression, and selective regulation of ovine prostaglandin H synthase-2. Biochem Biophys Res Commun 1996; 227:499-506.
38. Meade EA, Smith WL, DeWitt D. Expression of the murine prostaglandin (PGH) synthase-1 and PGH synthase-2 isozymes in cos-I cells. J Lipid Mediat 1993; 6:119-129.
39. Sirois J, Richards JS. Purification and characterization of a novel, distinct isoform of prostaglandin endoperoxide synthase induced by human chorionic gonadotropin in granulosa cells of rat preovulatory follicles. J Bioi Chern 1992; 267:6382-6388.
40. Feng L, Sun W, Xia Y, Tang WW, Chanmugam P, Soyoola E, Wilson CB, Hwang D. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch Biochem Biophys 1993; 307:361-368.
41. Kennedy BP, Chan CC, Culp SA, Cromlish WA. Cloning an expression of rat prostaglandin endoperoxide synthase (cyclooxygenase)-2 eDNA. Biochem Biophys Res Commun 1993; 197:494-500.
42. Regier MK, DeWitt DL, Schindler MS, Smith WL. Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells. Arch Biochem Biophys 1993; 301:439-444.
43. O’Neill GP, Ford-Hutchinson AW. Expression ofmRNA for cyclooxygenase-I and cyclooxygenase2 in human tissues. FEBS Lett 1993; 330:156-160.
44. Yamagata K, Andreasson KI, Kaufmann WE, Barnes CA, Worley PF. Expression of a mitogeninducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 1993; 11:371-386.
45. Crofford LJ, Wilder RL, Ristimaki AP, Sano H, Remmers EF, Epps HR, Hla T. CyclooxygenaseI and -2 expression in rheumatoid synovial tissues. J Clin Invest 1994; 93:1095-1101.
46. Andreis M, Stastny P, Ziff M. Experimental arthritis produced by mediators of delayed sensitivity. Arthritis Rheum 1974; 17:537-551.
47. Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, DuffGW. Correlation of plasma interleukin I levels with disease activity in rheumatoid arthritis. Lancet 1988; 2:706-709.
48. O’Neill GP, Mancini JA, Kargman S, Yergey J, Kwan MY, Falgueyret JP, Abramovitz M, Kennedy BP, Ouellet M, Cromlish W, Culp S, Evans IF, Ford-Hutchinson AW, Vickers PJ. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol Pharmacol 1993; 45:245-254.
49. Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W, Lee L, Isakson P. Pharmacological and biochemical demonstration of the role of cycooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 1994; 91:12013-12017.
50. Cromlish WA, Payette P, Culp SA, Ouellet M, Percival MD, Kennedy BP. High-level expression of active human cyclooxygenase-2 in insect cells. Arch Biochem Biophys 1994; 314:193-199.
51. Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler IF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 1995; 83:483-492.
52. Dinchuk IE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, Gorry SA, Trzaskos JM. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995; 378:406-409.
53. Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995; 83:473-482.
54. Chen J, Kelz MB, Zeng G, Sakai N, Steffen C, Shockett PE, Picciotto MR, Duman RS, Nestler EJ. Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol 1998; 54:495503.
55. Goldin AL. Ligand and Voltage-Gated Ion Channels. Vol 2. Boca Raton, FL: CRC Press, 1994.
56. Catterall WA. Cellular and molecular biology of voltage-gated sodium channels. Physiol Rev 1992; 72:S15-S48.
57. Fish LM, Sangameswaran L, Delgado SG, Koch BD, Jakeman, LB, Kwan J, Herman RC. Cloning of a sodium channel a-subunit (PN-l) from rat dorsal root ganglia. Soc Neurosci Abstr 1995; 21: 1824.
58. Klugbauer N, Lacinova L, Flockerzi V, Hofmann F. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-gated sodium channel family from human neuroendocrine cells. EMBO J. 1995; 14:1084-1090.
59. Mandel G. Tissue-specific expression of the voltage-sensitive sodium channel. J Membr BioI 1992; 125:193-205.
60. Akopian AN, Sivilotti L, Wood J. A tetrodotoxin-resistant voltage gated sodium channel expressed by sensory neurons. Nature 1996; 379:257-262.
61. Sangameswaran L, Delgado SG, Fish LM, Koc BD, Jakeman LB, Stewart GR, Sze P, Hunter JC, Eglen RM, Herman RC. Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons. J BioI Chern 1996; 271:5953-5956.
62. Toledo-Aral JJ, Moss BL, He Z, Koszowski AG, Whisenand T, Levinson SR, Wolf JJ, Silos-Santiago I, Halegoua S, Mandel G. Identification ofPN-l, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci USA 1997; 94:1527-1532.
63. Dib-Hajj SD, Tyrrell L, Black JA, Waxman SG. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc Natl Acad Sci USA 1998; 95:8963-8968.
64. Tate S, Benn S, Hick C, Trezise T, John V, Mannion R, Costigan M, Plumpton C, Grose D, Gladwell Z, Kendall G, Dale K, Bountra C, Woolf C. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurones. Nat Neurosci 1998; 1:653-655.
65. Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Bumstock G, Wood IN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 1995; 377:428-431.
66. Lewis C, Neidhart S, Holy C, North RA, Buell G, Surprenant A. Coexpression of P2X2 and P2X3 receptor subunits can account for ATP-gated currents in sensory neurons. Nature 1995; 377:432435.
67. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389:816-824.
68. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998; 21:531-543.
69. Fitzgerald M. The course and termination of primary afferent fibres. In: Textbook of Pain. Wall PD, Melzack R, eds. Churchill Livingstone, 1984; 34-48.
70. Perl ER. Function of dorsal root ganglion neurons: an overview. In: Scott SA, ed. Sensory Neurons. New York: Oxford University Press, 1992; 2-23.
71. Caffrey JM, Eng DL, Black JA, Waxman SG, Kocsis JD. Three types of sodium channels in adult rat dorsal root ganglion neurons. Brain Res 1992; 592:283-297.
72. Elliott AA, Elliott JR. Characterization ofTTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J Physiol 1993; 463:39-56.
73. Roy ML, Narahashi T. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion. J Neurosci 1992; 12:2104-2111.
74. Waxman SG, Kocsis JD, Black JA. Type ill sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is re-expressed following axotomy. J Neurophysiol 1994; 72: 466-470.
75. Black JA, Dib-Hajj S, Mcnabola K, Jeste S, Rizzo MA, Kocsis JD, Waxman SG. Spinal sensory neurons express multiple sodium channel a-subunit mRNAs. Mol Brain Res 1996; 43:117-131.
76. Black JA, Waxman SG. Sodium channel expression: a dynamic process in neurons and non-neuronal cells. Dev Neurosci 1996; 18:139-152.
77. Aguayo LG, White G. Effects of nerve growth factor on TTX and capsaicin-sensitivity in adult rat sensory neurons. Brain Res 1992; 570:61-67.
78. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurons via the cyclic AMP-protein kinase A cascade. J Physiol 1996; 495:429-440.
79. Gold MS, Reichling DB, Shuster MJ, Levin JD. Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc Natl Acad Sci USA 1996; 93:1108-1112.
80. Novakovic SD, Tzoumaka E, McGivern JG, Haraguchi M, Sangameswaran L, Gogas KR, Eglen RM, Hunter JC.Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J Neurosci 1998; 18:2174-2187.
81. Rizzo MA, Kocsis JD, Waxman SG. Slow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity. J Neurophysiol 1994; 72:2796-2815.
82. Haper AA, Lawson SN. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurons. J Physiol 1985; 359:31-46.
83. Scholz A, Appel N, Vogel W. Two types of TTX-resistant and one TTX-sensitive Na+ channel in rat dorsal root ganglion neurons and their blockade by halothane. Euro J Neurosci 1998; 10:25472556.