Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 880-886

  Zheng, Qing Zhong ^a   Zhang, Fei ^a   Cheng, Kui ^a   Yang, Ying ^a   Chen, Yu ^a   Qian, Yong ^a   Zhang, Hong Juan ^a   Li, Huan Qiu ^a   Zhou, Chang Fang ^a   An, Shu Qing ^a   Jiao, Qing Cai ^a   Zhu, Hai Liang ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Antitumor; Benzoic nitrogen mustard derivatives; EGFR; HER 2; Molecular docking

Indexed keywords

4 (BIS(2 CHLOROETHYL)AMINO) N (1 NAPHTHYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (2 BROMOPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (2 CHLOROPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (2 FLUOROPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (3 MORPHOLINOPROPYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (4 BROMOPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (4 CHLOROPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (4 FLUOROPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (4 ISOPROPYLPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (4 METHOXYPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N (4 NITROPHENYL)BENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N 4 TOLYLBENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N BUTYLBENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N CYCLOPENTYLBENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N DODECYLBENZAMID; 4 (BIS(2 CHLOROETHYL)AMINO) N METHYL N PHENYLBENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N TERT BUTYLBENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N,N DIBUTYLBENZAMIDE; 4 (BIS(2 CHLOROETHYL)AMINO) N,N DIPROPYLBENZAMIDE; ANTINEOPLASTIC AGENT; BENZAMIDE; CHLORMETHINE DERIVATIVE; CJS 1050; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; N [4 [(2 CHLOROETHYL)(2 MESYLOXYETHYL)AMINO]BENZOYL]GLUTAMIC ACID; N BENZYL 4 (BIS(2 CHLOROETHYL)AMINO)BENZAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELL STRAIN MCF 7; CONTROL GROUP; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

AMIDES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; NITROGEN MUSTARD COMPOUNDS; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76449102640     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.11.037     Document Type: Article

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