Tetraamine-derived bifunctional chelators for technetium-99m labelling: Synthesis, bioconjugation and evaluation as targeted SPECT imaging probes for GRP-receptor-positive tumours

Chemistry - A European Journal

Volumn 16, Issue 7, 2010, Pages 2115-2124

  Abiraj, Keelara ^a   Mansi, Rosalba ^a   Tamma, Maria Luisa ^a   Forrer, Flavio ^a   Cescato, Renzo ^b   Reubi, Jean Claude ^b   Akyel, Kayhan G ^c   Maecke, Helmut R ^a,d  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Antitumor agents; Bifunctional chelators; Imaging agents; Radiopharmaceuticals; Technetium

Indexed keywords

ANTI-TUMOR AGENTS; BIFUNCTIONAL; BIO-CONJUGATION; CLINICAL TRANSLATION; FACILE SYNTHESIS; HIGH AFFINITY; IMAGING AGENT; IMAGING AGENTS; IMAGING APPLICATIONS; IN-VIVO; LOW COSTS; MOBILISATION; PEPTIDE RECEPTOR; POST INJECTION; RADIOLABELLING; SPECIFIC ACTIVITY; SPECT IMAGING; STARTING MATERIALS; TECHNETIUM-99M; TUMOURS;

CALCIUM; ESTERS; FUNCTIONAL GROUPS; MEDICAL IMAGING; PEPTIDES; PHARMACOKINETICS; TECHNETIUM; TOMOGRAPHY; TUMORS;

CHELATION;

ANTINEOPLASTIC AGENT; BOMBESIN; CHELATING AGENT; DIAGNOSTIC AGENT; GASTRIN RELEASING PEPTIDE; POLYAMINE; RADIOPHARMACEUTICAL AGENT; TECHNETIUM; TECHNETIUM COMPLEX;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; ISOTOPE LABELING; METABOLISM; METHODOLOGY; MOUSE; NEOPLASM; NUDE MOUSE; SCINTISCANNING; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNTHESIS; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; BOMBESIN; CELL LINE, TUMOR; CHELATING AGENTS; GASTRIN-RELEASING PEPTIDE; HUMANS; ISOTOPE LABELING; MICE; MICE, NUDE; MOLECULAR STRUCTURE; NEOPLASMS; ORGANOTECHNETIUM COMPOUNDS; POLYAMINES; RADIOPHARMACEUTICALS; TECHNETIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 76449099768     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200902011     Document Type: Article

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