SUMO and ubiquitin paths converge

Biochemical Society Transactions

Volumn 38, Issue 1, 2010, Pages 34-39

  Denuc, Amanda ^a   Marfany, Gemma ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Antagonistic modulation; Cross talk; Small ubiquitin related modifier (SUMO); Synergistic outcome; Ubiquitin like molecule

Indexed keywords

CYCLINE; I KAPPA B KINASE GAMMA; LYSINE; NUCLEAR PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN MDM2; RING FINGER PROTEIN; SUMO PROTEIN; TOPORS PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR BMAL1; TRANSCRIPTION FACTOR CLOCK; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

CELLULAR DISTRIBUTION; CONJUGATION; DNA REPAIR; ENZYME ACTIVITY; GENOMIC INSTABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SUMOYLATION; UBIQUITINATION;

ANIMALS; CIRCADIAN RHYTHM; HUMANS; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 76449091871     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0380034     Document Type: Review

References (48)

1. Hunter, T. (2007) The age of crosstalk: phosphorylation, ubiquitination, and beyond. Mol. Cell 28, 730-738
2. Ciechanover, A. and Schwartz, A.L. (1998) The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc. Natl. Acad. Sci. U.S.A. 95, 2727-2730
3. Haglund, K. and Dikic, I. (2005) Ubiquitylation and cell signaling. EMBO J. 24, 3353-3359
4. Hay, R.T. (2005) SUMO: a history of modification. Mol. Cell 18, 1-12
5. Tatham, M.H., Jaffray, E., Vuaghan, O.A., Desterro, J.M., Botting, C.H., Naismith, J.H. and Hay, R.T. (2001) Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J. Biol. Chem. 276, 35368-35374
6. Matic, I., van Hagen, M., Schimmel, J., Macek, B., Ogg, S.C., Tatham, M.H., Hay, R.T., Lamond, A.I., Mann, M. and Vertegaal, A.C. (2008) In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. Mol. Cell. Proteomics 7, 132-144
7. Hurley, J.H., Lee, S. and Prag, G. (2006) Ubiquitin-binding domains. Biochem. J. 399, 361-372
8. Minty, A., Dumont, X., Kaghad, M. and Caput, D. (2000) Covalent modification of p73α by SUMO-1: two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J. Biol. Chem. 275, 36316-36323
9. Song, J., Durrin, L.K., Wilkinson, T.A., Krontiris, T.G. and Chen, Y. (2004) Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc. Natl. Acad. Sci. U.S.A. 101, 14373-14378
10. Yang, X.J. (2005) Multisite protein modification and intramolecular signaling. Oncogene 24, 1653-1662
11. Prudden, J., Pebernard, S., Raffa, G., Slavin, D.A., Perry, J.J., Tainer, J.A., McGowan, C.H. and Boddy, M.N. (2007) SUMO-targeted ubiquitin ligases in genome stability. EMBO J. 26, 4089-4101
12. Sun, H., Leverson, J.D. and Hunter, T. (2007) Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J. 26, 4102-4112
13. Uzunova, K., Gottsche, K., Miteva, M., Weisshaar, S.R., Glanemann, C., Schnellhardt, M., Niessen, M., Scheel, H., Hofmann, K., Johnson, E.S. et al. (2007) Ubiquitin-dependent proteolytic control of SUMO conjugates. J. Biol. Chem. 282, 34167-34175
14. Hunter, T. and Sun, H. (2008) Crosstalk between the SUMO and ubiquitin pathways. Ernst Schering Found. Symp. Proc. 1, 1-16
15. Darst, R.P., Garcia, S.N., Koch, M.R. and Pillus, L. (2008) Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol. Cell. Biol. 28, 1361-1372
16. Burgess, R.C., Rahman, S., Lisby, M., Rothstein, R. and Zhao, X. (2007) The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. Mol. Cell. Biol. 27, 6153-6162
17. Mullen, J.R., Kaliraman, V., Ibrahim, S.S. and Brill, S.J. (2001) Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics 157, 103-118
18. Azam, M., Lee, J.Y., Abraham, V., Chanoux, R., Schoenly, K.A. and Johnson, F.B. (2006) Evidence that the S. cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res. 34, 506-516
19. Boddy, M.N., Shanahan, P., McDonald, W.H., Lopez-Girona, A., Noguchi, E., Yates, I.J. and Russell, P. (2003) Replication checkpoint kinase Cds1 regulates recombinational repair protein Rad60. Mol. Cell. Biol. 23, 5939-5946
20. Schimmel, J., Larsen, K.M., Matic, I., van Hagen, M., Cox, J., Mann, M., Andersen, J.S. and Vertegaal, A.C. (2008) The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle. Mol. Cell. Proteomics 7, 2107-2122
21. Lallemand-Breitenbach, V., Jeanne, M., Benhenda, S., Nasr, R., Lei, M., Peres, L., Zhou, J., Zhu, J., Raught, B. and de The, H. (2008) Arsenic degrades PML or PML-RARα through a SUMO-triggered RNF4/ ubiquitin-mediated pathway. Nat. Cell Biol. 10, 547-555
22. Tatham, M.H., Geoffroy, M.C., Shen, L., Plechanovova, A., Hattersley, N., Jaffray, E.G., Palvimo, J.J. and Hay, R.T. (2008) RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat. Cell Biol. 10, 538-546
23. Nijman, S.M., Luna-Vargas, M.P., Velds, A., Brummelkamp, T.R., Dirac, A.M., Sixma, T.K. and Bernards, R. (2005) A genomic and functional inventory of deubiquitinating enzymes. Cell 123, 773-786
24. Komander, D., Clague, M.J. and Urbe, S. (2009) Breaking the chains: structure and function of the deubiquitinases. Nat. Rev. Mol. Cell Biol. 10, 550-563
25. Bosch-Comas, A., Lindsten, K., Gonzalez-Duarte, R., Masucci, M.G. and Marfany, G. (2006) The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins. Cell. Mol. Life Sci. 63, 723-734
26. Meulmeester, E., Kunze, M., Hsiao, H.H., Urlaub, H. and Melchior, F. (2008) Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25. Mol. Cell 30, 610-619
27. Denuc, A., Bosch-Comas, A., Gonzalez-Duarte, R. and Marfany, G. (2009) The UBA-UIM domains of the USP25 regulate the enzyme ubiquitination state and modulate substrate recognition. PLoS One 4, e5571
28. Marfany, G. and Denuc, A. (2008) To ubiquitinate or to deubiquitinate: it all depends on the partners. Biochem. Soc. Trans. 36, 833-838
29. Ventii, K.H. and Wilkinson, K.D. (2008) Protein partners of deubiquitinating enzymes. Biochem. J. 414, 161-175
30. Pichler, A., Knipscheer, P., Oberhofer, E., van Dijk, W.J., Korner, R., Olsen, J.V., Jentsch, S., Melchior, F. and Sixma, T.K. (2005) SUMO modification of the ubiquitin-conjugating enzyme E2-25K. Nat. Struct. Mol. Biol. 12, 264-269
31. Carter, S. and Vousden, K.H. (2009) Modifications of p53: competing for the lysines. Curr. Opin. Genet. Dev. 19, 18-24
32. Meek, D.W. and Knippschild, U. (2003) Post-translational modification of MDM2. Mol. Cancer Res. 1, 1017-1026
33. Buschmann, T., Fuchs, S.Y., Lee, C.G., Pan, Z.Q. and Ronai, Z. (2000) SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53. Cell 101, 753-762
34. Rajendra, R., Malegaonkar, D., Pungaliya, P., Marshall, H., Rasheed, Z., Brownell, J., Liu, L.F., Lutzker, S., Saleem, A. and Rubin, E.H. (2004) Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J. Biol. Chem. 279, 36440-36444
35. Yang, X., Li, H., Zhou, Z., Wang, W.H., Deng, A., Andrisani, O. and Liu, X. (2009) Plk1-mediated phosphorylation of Topors regulates p53 stability. J. Biol. Chem. 284, 18588-18592
36. Weger, S., Hammer, E. and Heilbronn, R. (2005) Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. FEBS Lett. 579, 5007-5012
37. Park, H.J., Zheng, H., Kulkarni, D., Kerrigan, J., Pungaliya, P., Saleem, A. and Rubin, E.H. (2008) Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity. Biochemistry 47, 13887-13896
38. Desterro, J.M., Rodriguez, M.S. and Hay, R.T. (1998) SUMO-1 modification of IκBα inhibits NF-κB activation. Mol. Cell 2, 233-239
39. Ulrich, H.D. (2005) Mutual interactions between the SUMO and ubiquitin systems: a plea of no contest. Trends Cell Biol. 15, 525-532
40. Huang, T.T., Wuerzberger-Davis, S.M., Wu, Z.H. and Miyamoto, S. (2003) Sequential modification of NEMO/IKKγ by SUMO-1 and ubiquitin mediates NF-κB activation by genotoxic stress. Cell 115, 565-576
41. Kwon, I., Lee, J., Chang, S.H., Jung, N.C., Lee, B.J., Son, G.H., Kim, K. and Lee, K.H. (2006) BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer. Mol. Cell. Biol. 26, 7318-7330
42. Lee, J., Lee, Y., Lee, M.J., Park, E., Kang, S.H., Chung, C.H., Lee, K.H. and Kim, K. (2008) Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex. Mol. Cell. Biol. 28, 6056-6065
43. Andersen, P.L., Xu, F. and Xiao, W. (2008) Eukaryotic DNA damage tolerance and translesion synthesis through covalent modifications of PCNA. Cell Res. 18, 162-173
44. Ulrich, H.D. (2009) Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair 8, 461-469
45. Hoege, C., Pfander, B., Moldovan, G.L., Pyrowolakis, G. and Jentsch, S. (2002) RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-1341
46. Krejci, L., Van Komen, S., Li, Y., Villemain, J., Reddy, M.S., Klein, H., Ellenberger, T. and Sung, P. (2003) DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Nature 423, 305-309
47. Papouli, E., Chen, S., Davies, A.A., Huttner, D., Krejci, L., Sung, P. and Ulrich, H.D. (2005) Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol. Cell 19, 123-133
48. Guo, C., Tang, T.S., Bienko, M., Parker, J.L., Bielen, A.B., Sonoda, E., Takeda, S., Ulrich, H.D., Dikic, I. and Friedberg, E.C. (2006) Ubiquitin-binding motifs in REV1 protein are required for its role in the tolerance of DNA damage. Mol. Cell. Biol. 26, 8892-8900