Effect of etoricoxib, a cyclooxygenase-2 selective inhibitor on aberrant crypt formation and apoptosis in 1,2 dimethyl hydrazine induced colon carcinogenesis in rat model

Nutricion Hospitalaria

Volumn 25, Issue 1, 2010, Pages 39-48

  Sharma, P ^a   Kaur, J ^a   Sanyal, S N ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Aberrant crypt foci; Apoptosis; Colon cancer; COX 2 expression; Etoricoxib; Non steroidal anti inflammatory drugs

Indexed keywords

ANIMALIA; RATTUS;

1,2 DIMETHYLHYDRAZINE; CARCINOGEN; CARRAGEENAN; CYCLOOXYGENASE 2 INHIBITOR; ETORICOXIB; PYRIDINE DERIVATIVE; SULFONE;

ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; COLITIS; COLON; COLON TUMOR; COMET ASSAY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; MALE; PATHOLOGY; RAT; SPRAGUE DAWLEY RAT;

1,2-DIMETHYLHYDRAZINE; ANIMALS; APOPTOSIS; CARCINOGENS; CARRAGEENAN; CELL PROLIFERATION; COLITIS; COLON; COLONIC NEOPLASMS; COMET ASSAY; CYCLOOXYGENASE 2 INHIBITORS; IMMUNOHISTOCHEMISTRY; MALE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SULFONES;

EID: 76449091435     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2010.25.1.4603     Document Type: Article

References (34)

1. Smith WI, Meade EA, Dewitt DL. Interaction of PGH synthase isozyme-1 and 2 with the NSAIDs. Ann NY Acad Sci 1994; 744: 50-57.
2. Marnett LJ. Aspirin and the potential role of prostaglandin in colon cancer. Cancer Res 1992; 52: 5575-5589.
3. Duperon C, Castongnoy A. Chemopreventive efficiencies of aspirin and sulindac against lung tumorigenesis in A/J mice. Carcinogenesis 1997; 18: 1001-1006.
4. Smith NT, Langenbach R. Why are there two cyclooxygenase enzymes? J Clin Invest 2001; 167: 1491-1495.
5. Levy GN. Prostaglandin H synthase, non-steroidal anti-inflammatory drugs and colon cancer. FASEB J 1997; 11: 234-247.
6. Smalley WE, DuBois RN. Colorectal cancer and non-steroidal anti-inflammatory drugs. FEBS Left 1997; 11: 234-247.
7. Warner TD, Mitchell JA. Cyclooxygenase: New forms, new inhibitors and lessons from the clinic. FASEB J 2004; 18: 790-804.
8. Kanwar SS, Vaiphei K, Nehru B et al. Chemopreventive effects of non-steroidal anti-inflammatory drugs in the membrane lipid composition and fluidity parameters of the 1,2 dimethyl hydrazine induced colon carcinogenesis in rats. Drug Chem Toxicol 2007; 30: 293-309.
9. Kanwar SS, Vaiphei K, Nehru B et al. Antioxidative effects of non steroidal anti-inflammatory drugs during the initiation stages of experimental colon carcinogenesis in rats. J Envir Pathol Tox Oncol 2008; 27(2): 89-100.
10. Bird RJ. Observation and generation of aberrant crypts in the murine colon treated with a colon carcinogenesis: Preliminary findings. Cancer Lett 1987; 37: 147-151.
11. Park H-S, Goodlad RA, Wright NA. The incidence of aberrant crypt foci and colonic carcinoma in dimethyl hydrazine treated rats varies in a site-specific manner and depends on tumor histology. Cancer Research 1997; 57: 4507-4510.
12. Paulson JE, Lqberg EM, Qlstora HB et al. Flat dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated rats. Cancer Res 2005; 65(1): 121-129.
13. Mouille B, Robert V, Blachier, F. Adaptive increase of ornithine production and decrease of ammonia metabolism in rat colonocytes and hyperproteic diet ingestion. Am J Physiol 2004; 287: G344-G351.
14. Roediger WEW, Truelove SC. Method of preparing isolated colonic epithelia cells (colonocytes) for metabolic studies. Gut 1979; 20: 484-488.
15. Baker AJ, Mooney A, Hughes J et al. Mesengial cell apoptosis: The major mechanism for resolution of glomerular hypercellularity in experimental mesengial proliferative nephritis. J Clin Invest 1994; 94: 2105-2116.
16. Schwartz LM, Obsorne BA. Cell death. Method Cell Biol 1995; 46: 15-18.
17. Yuan Y, Zhi-Qiang GE, Jing-Chuan L. Differentiation of apoptotic and necrotic cells in suspension cultures of Taxus cuspidate by the combined use of fluorescent dying and histochemical staining methods. Biotechnol Lett 2002; 24: 71-76.
18. Singh NP, McCoy MT, Tice RR et al. A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 1988; 175: 184-191.
19. Gupta GD, Gaud RS. Anti-inflammatory activity of tenoxicam gel on carrageenan induced paw oedema in rats. Indian J Pharm Sci 2006; 68(3): 356-359.
20. Shiptz B, Klein E, Bklan G et al. Suppressive effects of aspirin on aberrant crypt foci in patients with colorectal cancer. Gut 2003; 52: 1598-1601.
21. Subhashini J, Mahipal SVK, Reddanna P. Antiproliferative and apoptotic effects of celecoxib on human chronic myeloid leukemia in vitro. Cancer lett 2005; 224: 31-43.
22. Wargovich MJ, Jimenez A, McKee K et al. Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression. Carcinogenesis 2000; 21(6): 1149-1155.
23. Sheng H, Shao J, Morrow JD et al. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res 1998; 58: 362-366.
24. Dannenberg AJ, Altork NK, Boyle JC et al. Cyclooxygenase-2: A pharmacological target for the prevention of cancer. Lancet Oncol 2001; 2: 544-551.
25. Smets A. Programmed cell death (apoptosis) and response to anticancer drugs. Anticancer Drugs 1994; 5: 3-9.
26. Tsuji M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cell over expressing prostaglandin endoperoxide synthase 2. Cell 1995; 83: 493-501.
27. Fisher U, Jamicke RU, Schmlz-Osthof K. Many cuts to rain: A comprehensive uptake of caspase substrates. Cell Death Diff 2003; 10: 76-100.
28. Janicke R, Sprengart Ml, Wati MR et al. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998; 273: 9357-9360.
29. Park EJ, Kim KT, Kim CJ et al. Anticarcinogenic and Antigenotoxic Effects of Bacillus polyfermenticus. J Microbiol Biotechnol 2004; 14(4): 852-858.
30. Barth SW, Fahndrich C, Bub H et al. Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 2005; 24: 1414-1421.
31. Blobaum AL, Marnett LJ. Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib. J Biol Chem 2007; 282 (22): 16379-16390.
32. Owoyele VB, Wurada CO, Soladoye AO et al. Studies on the anti-inflammatory and analgesic properties of Tilhonic diverfolia leaf extract. J Ethnopharmacol 2004; 90: 317-321.
33. Sharma JN, Samuel AM, Asmawi MZ. Comparison between plethysmometer and micrometer method to measure acute paw oedema for screening anti-inflammatory activity in mice. Inflammaopharmacol 2004; 12 (1): 89-94.
34. Roy KR, Arunasree KM, Dhoot A et al. C-phycocyanin inhibits 2-acetylaminofluorescence induced expression of MDR-1 in mouse macrophages cells: ROS mediated pathway determined via combination of experimental and in silico analysis. Arch Biochem Biophys 2007; 459: 169-177.