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Volumn 36, Issue 3, 2010, Pages 244-250

A phase II study of cetuximab, capecitabine and radiotherapy in neoadjuvant treatment of patients with locally advanced resectable rectal cancer

Author keywords

Capecitabine; Cetuximab; Neoadjuvant chemoradiotherapy; Rectal cancer

Indexed keywords

CAPECITABINE; CETUXIMAB;

EID: 76449085548     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2009.12.002     Document Type: Article
Times cited : (49)

References (30)
  • 1
    • 0035975394 scopus 로고    scopus 로고
    • Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer
    • Kapiteijn E., Marijnen C.A., Nagtegaal I.D., et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345 9 (2001) 638-646
    • (2001) N Engl J Med , vol.345 , Issue.9 , pp. 638-646
    • Kapiteijn, E.1    Marijnen, C.A.2    Nagtegaal, I.D.3
  • 2
    • 0034706001 scopus 로고    scopus 로고
    • Preoperative radiotherapy for resectable rectal cancer: a meta-analysis
    • Camma C., Giunta M., Fiorica F., Pagliaro L., Craxi A., and Cottone M. Preoperative radiotherapy for resectable rectal cancer: a meta-analysis. JAMA 284 8 (2000) 1008-1015
    • (2000) JAMA , vol.284 , Issue.8 , pp. 1008-1015
    • Camma, C.1    Giunta, M.2    Fiorica, F.3    Pagliaro, L.4    Craxi, A.5    Cottone, M.6
  • 3
    • 0035922657 scopus 로고    scopus 로고
    • Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trials
    • Adjuvant radiotherapy for rectal cancer: a systematic overview of 8507 patients from 22 randomised trials. Lancet 358 9290 (2001) 1291-1304
    • (2001) Lancet , vol.358 , Issue.9290 , pp. 1291-1304
  • 4
    • 0028136295 scopus 로고
    • Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery
    • O'Connell M.J., Martenson J.A., Wieand H.S., et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med 331 8 (1994) 502-507
    • (1994) N Engl J Med , vol.331 , Issue.8 , pp. 502-507
    • O'Connell, M.J.1    Martenson, J.A.2    Wieand, H.S.3
  • 5
    • 6044226542 scopus 로고    scopus 로고
    • Preoperative versus postoperative chemoradiotherapy for rectal cancer
    • Sauer R., Becker H., Hohenberger W., et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 351 17 (2004) 1731-1740
    • (2004) N Engl J Med , vol.351 , Issue.17 , pp. 1731-1740
    • Sauer, R.1    Becker, H.2    Hohenberger, W.3
  • 6
    • 33750580102 scopus 로고    scopus 로고
    • Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203
    • Gerard J.P., Conroy T., Bonnetain F., et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203. J Clin Oncol 24 28 (2006) 4620-4625
    • (2006) J Clin Oncol , vol.24 , Issue.28 , pp. 4620-4625
    • Gerard, J.P.1    Conroy, T.2    Bonnetain, F.3
  • 7
    • 33748676449 scopus 로고    scopus 로고
    • Chemotherapy with preoperative radiotherapy in rectal cancer
    • Bosset J.F., Collette L., Calais G., et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 355 11 (2006) 1114-1123
    • (2006) N Engl J Med , vol.355 , Issue.11 , pp. 1114-1123
    • Bosset, J.F.1    Collette, L.2    Calais, G.3
  • 8
    • 3242716904 scopus 로고    scopus 로고
    • Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy
    • Bujko K., Nowacki M.P., Nasierowska-Guttmejer A., et al. Sphincter preservation following preoperative radiotherapy for rectal cancer: report of a randomised trial comparing short-term radiotherapy vs. conventionally fractionated radiochemotherapy. Radiother Oncol 72 1 (2004) 15-24
    • (2004) Radiother Oncol , vol.72 , Issue.1 , pp. 15-24
    • Bujko, K.1    Nowacki, M.P.2    Nasierowska-Guttmejer, A.3
  • 9
    • 0034016415 scopus 로고    scopus 로고
    • Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients
    • Schuller J., Cassidy J., Dumont E., et al. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chemother Pharmacol 45 4 (2000) 291-297
    • (2000) Cancer Chemother Pharmacol , vol.45 , Issue.4 , pp. 291-297
    • Schuller, J.1    Cassidy, J.2    Dumont, E.3
  • 10
    • 0033907949 scopus 로고    scopus 로고
    • Capecitabine, a new oral fluoropyrimidine for the treatment of colorectal cancer
    • Di Costanzo F., Sdrobolini A., and Gasperoni S. Capecitabine, a new oral fluoropyrimidine for the treatment of colorectal cancer. Crit Rev Oncol Hematol 35 2 (2000) 101-108
    • (2000) Crit Rev Oncol Hematol , vol.35 , Issue.2 , pp. 101-108
    • Di Costanzo, F.1    Sdrobolini, A.2    Gasperoni, S.3
  • 11
    • 0032695102 scopus 로고    scopus 로고
    • X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts
    • Sawada N., Ishikawa T., Sekiguchi F., Tanaka Y., and Ishitsuka H. X-ray irradiation induces thymidine phosphorylase and enhances the efficacy of capecitabine (Xeloda) in human cancer xenografts. Clin Cancer Res 5 10 (1999) 2948-2953
    • (1999) Clin Cancer Res , vol.5 , Issue.10 , pp. 2948-2953
    • Sawada, N.1    Ishikawa, T.2    Sekiguchi, F.3    Tanaka, Y.4    Ishitsuka, H.5
  • 12
    • 24944465683 scopus 로고    scopus 로고
    • Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer
    • Kim J.C., Kim T.W., Kim J.H., et al. Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 63 2 (2005) 346-353
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , Issue.2 , pp. 346-353
    • Kim, J.C.1    Kim, T.W.2    Kim, J.H.3
  • 13
    • 33750633689 scopus 로고    scopus 로고
    • Capecitabine as a radiosensitizing agent in neoadjuvant treatment of locally advanced resectable rectal cancer: prospective phase II trial
    • Velenik V., Anderluh F., Oblak I., Strojan P., and Zakotnik B. Capecitabine as a radiosensitizing agent in neoadjuvant treatment of locally advanced resectable rectal cancer: prospective phase II trial. Croat Med J 47 5 (2006) 693-700
    • (2006) Croat Med J , vol.47 , Issue.5 , pp. 693-700
    • Velenik, V.1    Anderluh, F.2    Oblak, I.3    Strojan, P.4    Zakotnik, B.5
  • 14
    • 17444403242 scopus 로고    scopus 로고
    • Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
    • Li S., Schmitz K.R., Jeffrey P.D., Wiltzius J.J., Kussie P., and Ferguson K.M. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell 7 4 (2005) 301-311
    • (2005) Cancer Cell , vol.7 , Issue.4 , pp. 301-311
    • Li, S.1    Schmitz, K.R.2    Jeffrey, P.D.3    Wiltzius, J.J.4    Kussie, P.5    Ferguson, K.M.6
  • 15
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
    • Goldstein N.I., Prewett M., Zuklys K., Rockwell P., and Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1 11 (1995) 1311-1318
    • (1995) Clin Cancer Res , vol.1 , Issue.11 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3    Rockwell, P.4    Mendelsohn, J.5
  • 16
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E., Kohne C.H., Hitre E., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360 14 (2009) 1408-1417
    • (2009) N Engl J Med , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 17
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C., Bondarenko I., Makhson A., et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27 5 (2009) 663-671
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 18
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 354 6 (2006) 567-578
    • (2006) N Engl J Med , vol.354 , Issue.6 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 19
    • 33646941041 scopus 로고    scopus 로고
    • Epidermal growth factor receptor as a prognostic factor in locally advanced rectal-cancer patients treated with preoperative chemoradiation
    • Li S., Kim J.S., Kim J.M., et al. Epidermal growth factor receptor as a prognostic factor in locally advanced rectal-cancer patients treated with preoperative chemoradiation. Int J Radiat Oncol Biol Phys 65 3 (2006) 705-712
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , Issue.3 , pp. 705-712
    • Li, S.1    Kim, J.S.2    Kim, J.M.3
  • 20
    • 34547445551 scopus 로고    scopus 로고
    • Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy
    • Bertolini F., Bengala C., Losi L., et al. Prognostic and predictive value of baseline and posttreatment molecular marker expression in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy. Int J Radiat Oncol Biol Phys 68 5 (2007) 1455-1461
    • (2007) Int J Radiat Oncol Biol Phys , vol.68 , Issue.5 , pp. 1455-1461
    • Bertolini, F.1    Bengala, C.2    Losi, L.3
  • 21
    • 58149345226 scopus 로고    scopus 로고
    • Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer
    • Bertolini F., Chiara S., Bengala C., et al. Neoadjuvant treatment with single-agent cetuximab followed by 5-FU, cetuximab, and pelvic radiotherapy: a phase II study in locally advanced rectal cancer. Int J Radiat Oncol Biol Phys 73 2 (2009) 466-472
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , Issue.2 , pp. 466-472
    • Bertolini, F.1    Chiara, S.2    Bengala, C.3
  • 22
    • 34047179551 scopus 로고    scopus 로고
    • Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer
    • Machiels J.P., Sempoux C., Scalliet P., et al. Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer. Ann Oncol 18 4 (2007) 738-744
    • (2007) Ann Oncol , vol.18 , Issue.4 , pp. 738-744
    • Machiels, J.P.1    Sempoux, C.2    Scalliet, P.3
  • 23
    • 0030990974 scopus 로고    scopus 로고
    • Pathological features of rectal cancer after preoperative radiochemotherapy
    • Dworak O., Keilholz L., and Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 12 1 (1997) 19-23
    • (1997) Int J Colorectal Dis , vol.12 , Issue.1 , pp. 19-23
    • Dworak, O.1    Keilholz, L.2    Hoffmann, A.3
  • 24
    • 67749097665 scopus 로고    scopus 로고
    • Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a phase II MARGIT trial
    • Horisberger K., Treschl A., Mai S., et al. Cetuximab in combination with capecitabine, irinotecan, and radiotherapy for patients with locally advanced rectal cancer: results of a phase II MARGIT trial. Int J Radiat Oncol Biol Phys (2009)
    • (2009) Int J Radiat Oncol Biol Phys
    • Horisberger, K.1    Treschl, A.2    Mai, S.3
  • 25
    • 0036787579 scopus 로고    scopus 로고
    • Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer
    • Dunst J., Reese T., Sutter T., et al. Phase I trial evaluating the concurrent combination of radiotherapy and capecitabine in rectal cancer. J Clin Oncol 20 19 (2002) 3983-3991
    • (2002) J Clin Oncol , vol.20 , Issue.19 , pp. 3983-3991
    • Dunst, J.1    Reese, T.2    Sutter, T.3
  • 26
    • 33947425624 scopus 로고    scopus 로고
    • A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer
    • Willeke F., Horisberger K., Kraus-Tiefenbacher U., et al. A phase II study of capecitabine and irinotecan in combination with concurrent pelvic radiotherapy (CapIri-RT) as neoadjuvant treatment of locally advanced rectal cancer. Br J Cancer 96 6 (2007) 912-917
    • (2007) Br J Cancer , vol.96 , Issue.6 , pp. 912-917
    • Willeke, F.1    Horisberger, K.2    Kraus-Tiefenbacher, U.3
  • 27
    • 65549151863 scopus 로고    scopus 로고
    • Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: a phase II study
    • Carlomagno C., Farella A., Bucci L., et al. Neo-adjuvant treatment of rectal cancer with capecitabine and oxaliplatin in combination with radiotherapy: a phase II study. Ann Oncol 20 (2009) 906-912
    • (2009) Ann Oncol , vol.20 , pp. 906-912
    • Carlomagno, C.1    Farella, A.2    Bucci, L.3
  • 28
    • 34147194443 scopus 로고    scopus 로고
    • Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the mercury study
    • Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the mercury study. Radiology 243 (2007) 132-139
    • (2007) Radiology , vol.243 , pp. 132-139
  • 29
    • 61649088414 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer
    • Bengala C., Bettelli S., Bertolini F., et al. Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer. Ann Oncol 20 3 (2009) 469-474
    • (2009) Ann Oncol , vol.20 , Issue.3 , pp. 469-474
    • Bengala, C.1    Bettelli, S.2    Bertolini, F.3
  • 30
    • 74049108229 scopus 로고    scopus 로고
    • Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer
    • Debucquoy A., Haustermans K., Daemen A., et al. Molecular response to cetuximab and efficacy of preoperative cetuximab-based chemoradiation in rectal cancer. J Clin Oncol 27 17 (2009) 2751-2757
    • (2009) J Clin Oncol , vol.27 , Issue.17 , pp. 2751-2757
    • Debucquoy, A.1    Haustermans, K.2    Daemen, A.3


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