In vivo requirement of the RNA polymerase II elongation factor elongin A for proper gene expression and development

Molecular and Cellular Biology

Volumn 24, Issue 22, 2004, Pages 9911-9919

  Gerber, Mark ^a   Eissenberg, Joel C ^a   Kong, Stephanie ^c   Tenney, Kristen ^a   Conaway, Joan Weliky ^c,d   Conaway, Ronald C ^c,d   Shilatifard, Ali ^a,b  

^a SAINT LOUIS UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY CANCER CENTER   (United States)

^c STOWERS INSTITUTE FOR MEDICAL RESEARCH   (United States)

^d UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGIN A; RNA POLYMERASE II; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LARVAL STAGE; MALE; METAMORPHOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; TISSUE SPECIFICITY;

AMINO ACID SEQUENCE; ANIMALS; CHROMOSOMES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; MOLECULAR SEQUENCE DATA; RNA INTERFERENCE; RNA POLYMERASE II; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS;

ANIMALIA; EUKARYOTA; NEPTUNIA;

EID: 7644244869     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.22.9911-9919.2004     Document Type: Article

References (44)

1. Aso, T., D. Haque, R. J. Barstead, R. C. Conaway, and J. W. Conaway. 1996. The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex. EMBO J. 15:5557-5566.
2. Aso, T., W. S. Lane, J. W. Conaway, and R. C. Conaway. 1995. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science 269: 1439-1443.
3. Aso, T., K. Yamazaki, K. Amimoto, A. Kuroiwa, H. Higashi, Y. Matsuda, S. Kitajima, and M. Hatakeyama. 2000. Identification and characterization of elongin A2, a new member of the elongin family of transcription elongation factors, specifically expressed in the testis. J. Biol Chem. 275:6546-6552.
4. Bradsher, J. N., K. W. Jackson, R. C. Conaway, and J. W. Conaway. 1993. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. J. Biol. Chem. 268:25587-25593.
5. Brower, C. S., S. Sato, C. Tomomori-Sato, T. Kamura, A. Pause, R. Stearman, R. D. Klausner, S. Malik, W. S. Lane, I. Sorokina, R. G. Roeder, J. W. Conaway, and R. C. Conaway. 2002. Mammalian mediator subunit mMEDS is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc. Natl. Acad. Sci. USA 99:10353-10358.
6. Cho, E. J., M. S. Kobor, M. Kim, J. Greenblatt, and S. Buratowski. 2001. Opposing effects of Ctk1 kinase and Fcp1 phosphatase at Ser 2 of the RNA polymerase II C-terminal domain. Genes Dev. 15:3319-3329.
7. Cockman, M. E., N. Masson, D. R. Mole, P. Jaakkola, G.-W. Chang, S. C. Clifford, E. R. Maher, C. W. Pugh, P. J. Ratcliffe, and P. H. Maxwell. 2000. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275:25733-25741.
8. Cohen, L. H., and B. V. Gotchel. 1971. Histones of polytene and nonpolytene nuclei of Drosophila melanogaster. J. Biol. Chem. 246:1841-1848.
9. Dahmus, M. E. 1996. Reversible phosphorylation of the C-terminal domain of RNA polymerase II. J. Biol. Chem. 271:19009-19012.
10. Eissenberg, J. C., J. Ma, M. A. Gerber, A. Christensen, J. A. Kennison, and A. Shilatifard. 2002. dELL is an essential RNA polymerase II elongation factor with a general role in development. Proc. Natl. Acad. Sci. USA 99:9894-9899.
11. Fristrom, J. W., R. J. Hill, and F. Watt. 1978. The procuticle of Drosophila: heterogeneity of urea-soluble proteins. Biochemistry 17:3917-3930.
12. Garrett, K., T. Aso, J. Bradsher, S. Foundling, W. Lane, R. Conaway, and J. Conaway. 1995. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. Proc. Natl. Acad. Sci. USA 92:7172-7176.
13. Garrett, K., S. Tan, J. Bradsher, W. Lane, J. Conaway, and R. Conaway. 1994. Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII. Proc. Natl. Acad. Sci. USA 91:5237-5241.
14. Gerber, M., J. Ma, K. Dean, J. C. Eissenberg, and A. Shilatifard. 2001. Drosophila ELL is associated with actively elongating RNA polymerase II on transcriptionally active sites in vivo. EMBO J. 20:6104-6114.
15. Giordano, E., R. Rendina, I. Peluso, and M. Furia. 2002. RNAi triggered by symmetrically transcribed transgenes in Drosophila melanogaster. Genetics 160:637-648.
16. Guo, S., Y. Yamaguchi, S. Schilbach, T. Wada, J. Lee, A. Goddard, D. French, H. Handa, and A. Rosenthal. 2000. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature 408:366-369.
17. Kamura, T., D. Burian, Q. Yan, S. L. Schmidt, W. S. Lane, E. Querido, P. E. Branton, A. Shilatifard, R. C. Conaway, and J. W. Conaway. 2001. MUF1, a novel Elongin BC-Interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J. Biol. Chem. 276: 29748-29753.
18. Kamura, T., D. M. Koepp, M. N. Conrad, D. Skowyra, R. J. Moreland, O. Iliopoulos, W. S. Lane, W. G. Kaelin, Jr., S. J. Elledge, R. C. Conaway, J. W. Harper, and J. W. Conaway. 1999. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science 284:657-661.
19. Kamura, T., S. Sato, D. Haque, L. Liu, W. G. J. Kaelin, R. C. Conaway, and J. W. Conaway. 1998. The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12:3872-3881.
20. Kamura, T., S. Sato, K. Iwai, M. Czyzyk-Krzeska, R. C. Conaway, and J. W. Conaway. 2000. Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc. Natl. Acad. Sci. USA 97:10430-10435.
21. Keegan, B. R., J. L. Feldman, D. H. Lee, D. S. Koos, R. K. Ho, D. Y. R. Stainier, and D. Yelon. 2002. The elongation factors Pandora/Spt6 and Foggy/Spt5 promote transcription in the zebrafish embryo. Development 129:1623-1632.
22. Komarnitsky, P., E. J. Cho, and S. Buratowski. 2000. Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev. 14:2452-2460.
23. Lavery, D., and U. Schibler. 1993. Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBP. Genes Dev. 7:1871-1884.
24. Marshall, N., and D. Price. 1992. Control of formation of two distinct classes of RNA polymerase II elongation complexes. Mol. Cell. Biol. 12:2078-2090.
25. Miller, T., K. Williams, R. W. Johnstone, and A. Shilatifard. 2000. Identification, cloning, expression, and biochemical characterization of the testis-specific RNA polymerase II elongation factor ELL3. J. Biol. Chem. 275: 32052-32056.
26. Myers, L. C., C. M. Gustafsson, D. A. Bushnell, M. Lui, H. Erdjument-Bromage, P. Tempst, and R. D. Kornberg. 1998. The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev. 12:45-54.
27. Ohh, M., C. W. Park, M. Ivan, M. A. Hoffman, T. Y. Kim, L. E. Huang, N. Pavletich, V. Chau, and W. G. Kaelin. 2000. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat. Cell Biol. 2:423-427.
28. Price, D. H. 2000. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol. Cell. Biol. 20:2629-2634.
29. Price, D. H., A. E. Sluder, and A. L. Greenleaf. 1989. Dynamic interaction between a Drosophila transcription factor and RNA polymerase II. Mol. Cell. Biol. 9:1465-1475.
30. Reines, D., M. J. Chamberlin, and C. M. Kane. 1989. Transcription elongation factor SII (TFIIS) enables RNA polymerase II to elongate through a block to transcription in a human gene in vitro. J. Biol. Chem. 264:10799-10809.
31. Reines, D., P. Ghanouni, W. Gu, J. Mote, Jr., and W. Powell. 1993. Transcription elongation by RNA polymerase II: mechanism of SII activation. Cell. Mol. Biol. Res. 39:331-338.
32. Reines, D., and J. Mote, Jr. 1993. Elongation factor SII-dependent transcription by RNA polymerase II through a sequence-specific DNA-binding protein. Proc. Natl. Acad. Sci. USA 90:1917-1921.
33. Rio, D. C., F. A. Laski, and G. M. Rubin. 1986. Identification and immunochemical analysis of biologically active Drosophila P element transposase. Cell 44:21-32.
34. Serizawa, H., R. C. Conaway, and J. W. Conaway. 1992. A carboxyl-terminaldomain kinase associated with RNA polymerase II transcription factor delta from rat liver. Proc. Natl. Acad. Sci. USA 89:7476-7480.
35. Shilatifard, A., R. C. Conaway, and J. W. Conaway. 2003. The RNA polymerase II elongation complex. Annu. Rev. Biochem. 72:693-715.
36. Shilatifard, A., D. R. Duan, D. Haque, C. Florence, W. H. Schubach, J. W. Conaway, and R. C. Conaway. 1997. ELL2, a new member of an ELL family of RNA polymerase II elongation factors. Proc. Natl. Acad. Sci. USA 94: 3639-3643.
37. Shilatifard, A., W. S. Lane, K. W. Jackson, R. C. Conaway, and J. W. Conaway. 1996. An RNA polymerase II elongation factor encoded by the human ELL gene. Science 271:1873-1876.
38. Sluder, A. E., A. L. Greenleaf, and D. H. Price. 1989. Properties of a Drosophila RNA polymerase II elongation factor. J. Biol. Chem. 264:8963-8969.
39. Snyder, M., J. Hirsh, and N. Davidson. 1981. The cuticle genes of drosophila: a developmentally regulated gene cluster. Cell 25:165-177.
40. Spradling, A. C. 1986. P element mediated transformation, p. 175-197. In D. B. Roberts (ed.), Drosophila, a practical approach. IRL Press, Oxford, United Kingdom.
41. Wada, T., T. Takagi, Y. Yamaguchi, D. Watanabe, and H. Handa. 1998. Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. EMBO J. 17:7395-7403.
42. Yamaguchi, Y., T. Wada, D. Watanabe, T. Takagi, J. Hasegawa, and H. Handa. 1999. Structure and function of the human transcription elongation factor DSIF. J. Biol. Chem. 274:8085-8092.
43. Yamazaki, K., T. Aso, Y. Ohnishi, M. Ohno, K. Tamura, T. Shuin, S. Kitajima, and Y. Nakabeppu. 2003. Mammalian elongin A is not essential for cell viability but required for proper cell-cycle progression with limited alteration of gene expression. J. Biol. Chem. 278:13585-13589.
44. Yamazaki, K., L. Guo, K. Sugahara, C. Zhang, H. Enzan, Y. Nakabeppu, S. Kitajima, and T. Aso. 2002. Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3. J. Biol. Chem. 277: 26444-26451.