메뉴 건너뛰기




Volumn 25, Issue 12, 2009, Pages 2239-2245

Nutrient medium optimization for hyoscyamine production in diploid and tetraploid Datura stramonium L. hairy root cultures

Author keywords

Alkaloid profiles; Datura stramonium L.; GC MS; Hairy roots; Medium optimization; Ploidy level

Indexed keywords

HAIRY ROOT CULTURE; HAIRY ROOTS; MEDIUM OPTIMIZATION; NUTRIENT MEDIA; NUTRIENT MEDIUM; OPTIMAL CONCENTRATION; OPTIMIZATION PROCEDURES; PLOIDY LEVELS; PRODUCTION YIELD; REGRESSION MODEL;

EID: 76349110799     PISSN: 09593993     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11274-009-0131-2     Document Type: Article
Times cited : (9)

References (34)
  • 2
    • 0035936598 scopus 로고    scopus 로고
    • The effect of nitrate and ammonium concentrations on growth and alkaloid accumulation of Atropa belladonna hairy roots
    • Bensaddek L, Gillet F, Saucedo JEN, Fliniaux MA (2001) The effect of nitrate and ammonium concentrations on growth and alkaloid accumulation of Atropa belladonna hairy roots. J Biotechnol 85(1): 35-40.
    • (2001) J Biotechnol , vol.85 , Issue.1 , pp. 35-40
    • Bensaddek, L.1    Gillet, F.2    Saucedo, J.E.N.3    Fliniaux, M.A.4
  • 3
    • 2642515567 scopus 로고    scopus 로고
    • A rapid densitometric method for the analysis of hyoscyamine and scopolamine in solanaceous plants and their transformed root cultures
    • Berkov S, Pavlov A (2004) A rapid densitometric method for the analysis of hyoscyamine and scopolamine in solanaceous plants and their transformed root cultures. Phytochem Anal 15(3): 141-145.
    • (2004) Phytochem Anal , vol.15 , Issue.3 , pp. 141-145
    • Berkov, S.1    Pavlov, A.2
  • 4
    • 0036998664 scopus 로고    scopus 로고
    • Alkaloid production in diploid and autotetraploid plants of Datura stramonium
    • Berkov S, Philipov S (2002) Alkaloid production in diploid and autotetraploid plants of Datura stramonium. Pharm Biol 40(8): 617-621.
    • (2002) Pharm Biol , vol.40 , Issue.8 , pp. 617-621
    • Berkov, S.1    Philipov, S.2
  • 5
    • 0345549541 scopus 로고    scopus 로고
    • Alkaloid spectrum in diploid and tetraploid hairy root cultures of Datura stramonium
    • Berkov S, Pavlov A, Kovatcheva P, Stanimirova P, Philipov S (2003) Alkaloid spectrum in diploid and tetraploid hairy root cultures of Datura stramonium. Z Naturforsch [C] 58(1-2): 42-46.
    • (2003) Z Naturforsch [C] , vol.58 , Issue.1-2 , pp. 42-46
    • Berkov, S.1    Pavlov, A.2    Kovatcheva, P.3    Stanimirova, P.4    Philipov, S.5
  • 6
    • 0342733368 scopus 로고    scopus 로고
    • Influence of feeding precursors on tropane alkaloid production during an abiotic stress in Datura innoxia transformed roots
    • Boitel-Conti M, Laberche JC, Lanoue A, Ducrocq C, Sangwan-Norreel BS (2000) Influence of feeding precursors on tropane alkaloid production during an abiotic stress in Datura innoxia transformed roots. Plant Cell Tissue Organ Cult 60(2): 131-137.
    • (2000) Plant Cell Tissue Organ Cult , vol.60 , Issue.2 , pp. 131-137
    • Boitel-Conti, M.1    Laberche, J.C.2    Lanoue, A.3    Ducrocq, C.4    Sangwan-Norreel, B.S.5
  • 7
    • 0038325642 scopus 로고    scopus 로고
    • Tetraploid Artemisia annua hairy roots produce more artemisinin than diploids
    • De Jesus-Gonzalez L, Weathers PJ (2003) Tetraploid Artemisia annua hairy roots produce more artemisinin than diploids. Plant Cell Rep 21(8): 809-813.
    • (2003) Plant Cell Rep , vol.21 , Issue.8 , pp. 809-813
    • de Jesus-Gonzalez, L.1    Weathers, P.J.2
  • 8
    • 0030038334 scopus 로고    scopus 로고
    • Enhancing the productivity of secondary metabolites via induced polyploidy: A review
    • Dhawan OP, Lavania UC (1996) Enhancing the productivity of secondary metabolites via induced polyploidy: a review. Euphytica 87(2): 22280.
    • (1996) Euphytica , vol.87 , Issue.2 , pp. 22280
    • Dhawan, O.P.1    Lavania, U.C.2
  • 9
    • 0002222850 scopus 로고
    • Isolation and maintenance of callus and cell suspension cultures
    • R. A. Dixon (Ed.), Oxford: IRL Press
    • Dixon RA (1985) Isolation and maintenance of callus and cell suspension cultures. In: Dixon RA (ed) Plant cell culture: a practical approach. IRL Press, Oxford, pp 1-20.
    • (1985) Plant Cell Culture: A Practical Approach , pp. 1-20
    • Dixon, R.A.1
  • 10
    • 0014374588 scopus 로고
    • The alkaloids of the genus Datura, section brugmansia. Part V. Alkaloids of D. sanguinea R. and P. and related esters of tropane-3O±, 6OI, 7OI-triol
    • Evans WC, Major VA (1968) The alkaloids of the genus Datura, section brugmansia. Part V. Alkaloids of D. sanguinea R. and P. and related esters of tropane-3O±, 6OI, 7OI-triol. J Chem Soc C: Organic: 2775-2778.
    • (1968) J Chem Soc C: Organic , pp. 2775-2778
    • Evans, W.C.1    Major, V.A.2
  • 11
    • 52049106424 scopus 로고    scopus 로고
    • Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs
    • Grynkiewicz G, Gadzikowska M (2008) Tropane alkaloids as medicinally useful natural products and their synthetic derivatives as new drugs. Pharmacol Rep 60(4): 439-463.
    • (2008) Pharmacol Rep , vol.60 , Issue.4 , pp. 439-463
    • Grynkiewicz, G.1    Gadzikowska, M.2
  • 12
    • 0036332024 scopus 로고    scopus 로고
    • Metabolic engineering of plants for alkaloid production
    • Hughes EH, Shanks JV (2002) Metabolic engineering of plants for alkaloid production. Metab Eng 4(1): 41-48.
    • (2002) Metab Eng , vol.4 , Issue.1 , pp. 41-48
    • Hughes, E.H.1    Shanks, J.V.2
  • 13
    • 0030806498 scopus 로고    scopus 로고
    • Rosmarinic acid production by Lavandula vera MM cell-suspension culture
    • Ilieva M, Pavlov A (1997) Rosmarinic acid production by Lavandula vera MM cell-suspension culture. Appl Microbiol Biotechnol 47(6): 683-688.
    • (1997) Appl Microbiol Biotechnol , vol.47 , Issue.6 , pp. 683-688
    • Ilieva, M.1    Pavlov, A.2
  • 14
    • 0027934137 scopus 로고
    • Spectrum of tropane alkaloids in transformed roots of Datura innoxia and Hyoscyamus x gyorffyi cultivated in vitro
    • Ionkova I, Witte L, Alfermann AW (1994) Spectrum of tropane alkaloids in transformed roots of Datura innoxia and Hyoscyamus x gyorffyi cultivated in vitro. Planta Med 60(4): 382-384.
    • (1994) Planta Med , vol.60 , Issue.4 , pp. 382-384
    • Ionkova, I.1    Witte, L.2    Alfermann, A.W.3
  • 15
    • 25844474691 scopus 로고    scopus 로고
    • Genomic and ploidy manipulation for enhanced production of phyto-pharmaceuticals
    • Lavania UC (2005) Genomic and ploidy manipulation for enhanced production of phyto-pharmaceuticals. Plant Genet Resour 3(2): 170-177.
    • (2005) Plant Genet Resour , vol.3 , Issue.2 , pp. 170-177
    • Lavania, U.C.1
  • 16
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bioassays with tobacco tissue cultures
    • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-479.
    • (1962) Physiol Plant , vol.15 , pp. 473-479
    • Murashige, T.1    Skoog, F.2
  • 17
    • 0346942250 scopus 로고    scopus 로고
    • Hairy roots of Datura candida x D. aurea: Effect of culture medium composition on growth and alkaloid biosynthesis
    • Nussbaumer P, Kapetanidis I, Christen P (1998) Hairy roots of Datura candida x D. aurea: effect of culture medium composition on growth and alkaloid biosynthesis. Plant Cell Rep 17(5): 405-409.
    • (1998) Plant Cell Rep , vol.17 , Issue.5 , pp. 405-409
    • Nussbaumer, P.1    Kapetanidis, I.2    Christen, P.3
  • 18
    • 34548323862 scopus 로고    scopus 로고
    • Tropane and nicotine alkaloid biosynthesis-novel approaches towards biotechnological production of plant-derived pharmaceuticals
    • Oksman-Caldentey KM (2007) Tropane and nicotine alkaloid biosynthesis-novel approaches towards biotechnological production of plant-derived pharmaceuticals. Curr Pharm Biotechnol 8(4): 203-210.
    • (2007) Curr Pharm Biotechnol , vol.8 , Issue.4 , pp. 203-210
    • Oksman-Caldentey, K.M.1
  • 19
    • 0001120062 scopus 로고
    • Variation in tropane alkaloid accumulation within the solanaceae and strategies for its exploitation
    • Parr AJ, Payne J, Eagles J, Chapman BT, Robins RJ, Rhodes MJC (1990) Variation in tropane alkaloid accumulation within the solanaceae and strategies for its exploitation. Phytochemistry 29(8): 2545-2550.
    • (1990) Phytochemistry , vol.29 , Issue.8 , pp. 2545-2550
    • Parr, A.J.1    Payne, J.2    Eagles, J.3    Chapman, B.T.4    Robins, R.J.5    Rhodes, M.J.C.6
  • 20
    • 0036796134 scopus 로고    scopus 로고
    • Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process
    • Patterson S, O'Hagan D (2002) Biosynthetic studies on the tropane alkaloid hyoscyamine in Datura stramonium; hyoscyamine is stable to in vivo oxidation and is not derived from littorine via a vicinal interchange process. Phytochemistry 61(3): 323-329.
    • (2002) Phytochemistry , vol.61 , Issue.3 , pp. 323-329
    • Patterson, S.1    O'Hagan, D.2
  • 21
    • 0036631124 scopus 로고    scopus 로고
    • Biosynthesis and radical scavenging activity of betalains during the cultivation of red beet (Beta vulgaris) hairy root cultures
    • Pavlov A, Kovatcheva P, Georgiev V, Koleva I, Ilieva M (2002) Biosynthesis and radical scavenging activity of betalains during the cultivation of red beet (Beta vulgaris) hairy root cultures. Z Naturforsch [C] 57(7-8): 640-644.
    • (2002) Z Naturforsch [C] , vol.57 , Issue.7-8 , pp. 640-644
    • Pavlov, A.1    Kovatcheva, P.2    Georgiev, V.3    Koleva, I.4    Ilieva, M.5
  • 22
    • 67649889074 scopus 로고    scopus 로고
    • Hyoscyamine biosynthesis in Datura stramonium hairy root in vitro systems with different ploidy levels
    • Pavlov A, Berkov S, Weber J, Bley T (2008) Hyoscyamine biosynthesis in Datura stramonium hairy root in vitro systems with different ploidy levels. Appl Biochem Biotechnol 157(2): 210-225.
    • (2008) Appl Biochem Biotechnol , vol.157 , Issue.2 , pp. 210-225
    • Pavlov, A.1    Berkov, S.2    Weber, J.3    Bley, T.4
  • 23
    • 0036560618 scopus 로고    scopus 로고
    • GC-MS investigation of tropane alkaloids in Datura stramonium
    • Philipov S, Berkov S (2002) GC-MS investigation of tropane alkaloids in Datura stramonium. Z Naturforsch [C] 57(5-6): 559-561.
    • (2002) Z Naturforsch [C] , vol.57 , Issue.5-6 , pp. 559-561
    • Philipov, S.1    Berkov, S.2
  • 24
    • 17044451407 scopus 로고    scopus 로고
    • Influence of calcium ion-concentration in the medium on tropane alkaloid accumulation in Datura stramonium hairy roots
    • Pinol MT, Palazon J, Cusido RM, Ribo M (1999) Influence of calcium ion-concentration in the medium on tropane alkaloid accumulation in Datura stramonium hairy roots. Plant Sci 141(1): 41-49.
    • (1999) Plant Sci , vol.141 , Issue.1 , pp. 41-49
    • Pinol, M.T.1    Palazon, J.2    Cusido, R.M.3    Ribo, M.4
  • 25
    • 0031684336 scopus 로고    scopus 로고
    • Novel biotechnological approaches to obtain scopolamine and hyoscyamine: The influence of biotic elicitors and stress agents on cultures of transformed roots of Brugmansia candida
    • Pitta-Alvarez SI, Giulietti AM (1998) Novel biotechnological approaches to obtain scopolamine and hyoscyamine: The influence of biotic elicitors and stress agents on cultures of transformed roots of Brugmansia candida. Phytother Res 12(Suppl 1): S18-S20.
    • (1998) Phytother Res , vol.12 , Issue.SUPPL. 1
    • Pitta-Alvarez, S.I.1    Giulietti, A.M.2
  • 26
    • 0034135614 scopus 로고    scopus 로고
    • The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida
    • Pitta-Alvarez SI, Spollansky TC, Giulietti AM (2000) The influence of different biotic and abiotic elicitors on the production and profile of tropane alkaloids in hairy root cultures of Brugmansia candida. Enzyme Microb Technol 26(2-4): 252-258.
    • (2000) Enzyme Microb Technol , vol.26 , Issue.2-4 , pp. 252-258
    • Pitta-Alvarez, S.I.1    Spollansky, T.C.2    Giulietti, A.M.3
  • 27
    • 0000388887 scopus 로고    scopus 로고
    • Datura stramonium hairy roots tropane alkaloid content as a response to changes in Gamborg's B5 medium
    • Saenz-Carbonell L, Loyola-Vargas VM (1996) Datura stramonium hairy roots tropane alkaloid content as a response to changes in Gamborg's B5 medium. Appl Biochem Biotechnol [A] 61(3): 321-337.
    • (1996) Appl Biochem Biotechnol [A] , vol.61 , Issue.3 , pp. 321-337
    • Saenz-Carbonell, L.1    Loyola-Vargas, V.M.2
  • 28
    • 0036774867 scopus 로고    scopus 로고
    • Agrobacterium rhizogenes-mediated transformation: Root cultures as a source of alkaloids
    • Sevon N, Oksman-Caldentey KM (2002) Agrobacterium rhizogenes-mediated transformation: Root cultures as a source of alkaloids. Planta Med 68(10): 859-868.
    • (2002) Planta Med , vol.68 , Issue.10 , pp. 859-868
    • Sevon, N.1    Oksman-Caldentey, K.M.2
  • 29
    • 0030432157 scopus 로고    scopus 로고
    • Influence of the ion-composition of the medium on alkaloid production by 'hairy roots' of Datura stramonium
    • Sikuli NN, Demeyer K (1996) Influence of the ion-composition of the medium on alkaloid production by 'hairy roots' of Datura stramonium. Plant Cell Tissue Organ Cult 47(3): 261-267.
    • (1996) Plant Cell Tissue Organ Cult , vol.47 , Issue.3 , pp. 261-267
    • Sikuli, N.N.1    Demeyer, K.2
  • 30
    • 53049095144 scopus 로고    scopus 로고
    • Flow cytometric investigations of diploid and tetraploid plants and in vitro cultures of Datura stramonium and Hyoscyamus niger
    • Weber J, Georgiev V, Pavlov A, Bley T (2008) Flow cytometric investigations of diploid and tetraploid plants and in vitro cultures of Datura stramonium and Hyoscyamus niger. Cytometry [A] 73(10): 931-939.
    • (2008) Cytometry [A] , vol.73 , Issue.10 , pp. 931-939
    • Weber, J.1    Georgiev, V.2    Pavlov, A.3    Bley, T.4
  • 31
    • 0023101054 scopus 로고
    • Investigation of the alkaloid pattern of Datura innoxia plants by capillary gas-liquid-chromatography-mass spectrometry
    • Witte L, Muller K, Arfmann HA (1987) Investigation of the alkaloid pattern of Datura innoxia plants by capillary gas-liquid-chromatography-mass spectrometry. Planta Med 53(2): 192-197.
    • (1987) Planta Med , vol.53 , Issue.2 , pp. 192-197
    • Witte, L.1    Muller, K.2    Arfmann, H.A.3
  • 32
    • 0001967948 scopus 로고    scopus 로고
    • Plant biotechnology of tropane alkaloids
    • Yamada Y, Tabata M (1997) Plant biotechnology of tropane alkaloids. Plant Biotechnol 14(1): 1-10.
    • (1997) Plant Biotechnol , vol.14 , Issue.1 , pp. 1-10
    • Yamada, Y.1    Tabata, M.2
  • 33
    • 0032928404 scopus 로고    scopus 로고
    • Elicitation of tropane alkaloid biosynthesis in transformed root cultures of Datura stramonium
    • Zabetakis I, Edwards R, O'Hagan D (1999) Elicitation of tropane alkaloid biosynthesis in transformed root cultures of Datura stramonium. Phytochemistry 50(1): 53-56.
    • (1999) Phytochemistry , vol.50 , Issue.1 , pp. 53-56
    • Zabetakis, I.1    Edwards, R.2    O'Hagan, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.