Immunomodulatory activity of a plant extract containing human papillomavirus 16-E7 protein in human monocyte-derived dendritic cells

International Journal of Immunopathology and Pharmacology

Volumn 22, Issue 4, 2009, Pages 967-978

  Di Bonito, P ^a   Grasso, F ^a   Mangino, G ^b   Massa, S ^c   Illiano, E ^c   Franconi, R ^c   Fanales Belasio, E ^a   Falchi, M ^a   Affabris, E ^b   Giorgi, C ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b ROMA TRE UNIVERSITY   (Italy)

^c ENEA   (Italy)

Author keywords

Dendritic cells; E7 protein; HPV16; Plant extract; Plant vaccine

Indexed keywords

BIOLOGICAL MARKER; FLUORESCEIN ISOTHIOCYANATE; NICOTIANA BENTAMIANA EXTRACT; OVALBUMIN; PLANT EXTRACT; PROTEIN E7; TUMOR VACCINE; UNCLASSIFIED DRUG;

ARTICLE; CANCER IMMUNOTHERAPY; CELL DIFFERENTIATION; CELL MATURATION; DENDRITIC CELL; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MIXTURE; DRUG SCREENING; EXPRESSION VECTOR; FEMALE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; IMMUNOMODULATION; LYMPHOCYTE; MALE; MEDICINAL PLANT; MONOCYTE; NICOTIANA BENTAMIANA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PLANT LEAF; POTEXVIRUS; PRIORITY JOURNAL;

EID: 76349107131     PISSN: 03946320     EISSN: None     Source Type: Journal    
DOI: 10.1177/039463200902200412     Document Type: Article

References (27)

1. Campo MS. Papillomavirus Research: From Natural History to Vaccines and Beyond. Edited by MS Campo, Caister Academic Press, Norwich, UK, 2006; p. 1-424.
2. Müller M, Gissmann L. A long way: history of the prophylactic papillomavirus vaccine. Dis Markers 2007; 23:331-36.
3. Wu TC. Therapeutic human papillomavirus DNA vaccination strategies to control cervical cancer. Eur J Immunol 2007; 37:310-14.
4. Hung CF, Ma B, Monie A, Tsen SW, Wu TC. Therapeutic human papillomavirus vaccines: current clinical trials and future directions Expert Opin Biol Ther 2008; 8:421-39.
5. Kanodia S, Da Silva DM, Kast WM. Recent advances in strategies for immunotherapy of human papillomavirus-induced lesions. Int J Cancer 2008; 122: 247-59.
6. Bellone S, Pecorelli S, Cannon MJ, Santin AD. Advances in dendritic-cell-based therapeutic vaccines for cervical cancer. Expert Rev Anticancer Ther 2007; 7:1473-86.
7. Franconi R, Di Bonito P, Dibello F, et al. Plant-derived human papillomavirus 16 E7 oncoprotein induces immune response and specific tumour protection. Cancer Research 2002; 62:3654-58.
8. Franconi R, Massa S, Illiano E, Mullar A, Cirilli A, Accardi L, Di Bonito P, Giorgi C, Venuti A. Exploiting the plant secretory pathway to improve the anticancer activity of a plant-derived HPV16 E7 vaccine. Int J Immunopathol Pharmacol 2006; 19:187-97.
9. Di Bonito P, Grasso F, Mochi S, et al. Serum antibody response to Human papillomavirus (HPV) infections detected by a novel ELISA technique based on denatured recombinant HPV16 L1, L2, E4, E6 and E7 proteins. Infect Agent Cancer 2006; 8:1-6.
10. Franken KL, Hiemstra HS, van Meijgaarden KE, Subronto Y, den Hartigh J, Ottenhoff TH, Drijfhout JW. Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent. Protein Expr Purif 2000; 18:95-99.
11. Reichelt P, Schwarz C, Donzeau M. Single step protocol to purify recombinant proteins with low endotoxin contents. Protein Expr Purif 2006; 46:483-88.
12. Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994; 179:1109-18.
13. Fanales-Belasio E, Moretti S, Nappi F, Barillari G, Micheletti F, Cafaro A, Ensoli B. Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses. J Immunol 2002; 168:197-206.
14. Dengler WA, Schulte J, Berger DP, Mertelsmann R, Fiebig HH. Development of a propidium iodide fluorescence assay for proliferation and cytotoxicity assays. Anticancer Drugs 1995; 6:522-32.
15. Kass R, Agha J, Bellone S, et al. In vitro induction of tumor-specific HLA class I-restricted CD8+ cytotoxic T lymphocytes from patients with locally advanced breast cancer by tumor antigen-pulsed autologous dendritic cells. J Surg Res 2003; 112:189-97.
16. Santin AD, Hermonat PL, Ravaggi A, Chiriva-Internati M, Zhan D, Pecorelli S, Parham GP, Cannon MJ. Induction of human papillomavirus-specific CD4(+) and CD8(+) lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16- and 18-positive cervical cancer. J Virol 1999; 73:5402-10.
17. Santin AD, Bellone S, Palmieri M, et al. HPV16/18 E7-pulsed dendritic cell vaccination in cervical cancer patients with recurrent disease refractory to standard treatment modalities. Gynecol Oncol 2006; 100:469-78.
18. Stein GM, Bussing A, Schietzel M. Activation of dendritic cells by an aqueous mistletoe extract and mistletoe lectin-3 in vitro. Anticancer Res 2002; 22:267-74.
19. Stein GM, Bussing A, Schietzel M. Stimulation of the maturation of dendritic cells in vitro by a fermented mistletoe extract. Anticancer Res 2002; 22:4215-19.
20. Bradley WG, Widen RH, Weiser AM, et al. The novel differentiation of human blood mononuclear cells into CD1a-negative dendritic cells is stimulated in the absence of exogenous cytokines by an extract prepared from pinecones. Int Immunopharmacol 2003; 3:209-23.
21. Nikulina M, Habich C, Flohé SB, Scott FW, Kolb H. Wheat gluten causes dendritic cell maturation and chemokine secretion. J Immunol 2004; 173:1925-33.
22. Lacasse P, Denis J, Lapointe R, Leclerc D, Lamarre A. Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation. J Virol 2008; 82:785-94.
23. D 'Anna R, Le Buanec H, Bizzini B, Burny A, Giannouli C, Zagury JF, Gallo RC, Zagury D, D'Alessio P. Human papillomavirus-16-E7 oncoprotein enhances the expression of adhesion molecules in cervical endothelial cells but not in human umbilical vein endothelial cells. J Hum Virol 2001; 4:85-95.
24. Richard JP, Melikov K, Vives E, Ramos C, Verbeure B, Gait MJ, Chernomordik LV, Lebleu B. Cell-penetrating peptides. A re-evaluation of the mechanism of cellular uptake. J Biol Chem 2003; 278:585-90.
25. Säälik P, Elmquist A, Hansen M, Padari K, Saar K, Viht K, Langel U, Pooga M. Protein cargo delivery properties of cell-penetrating peptides. A comparative study Bioconjug Chem 2004; 15:1246-53.
26. Duchardt F, Fotin-Mleczek M, Schwarz H, Fischer R, Brock R. A comprehensive model for the cellular uptake of cationic cell-penetrating peptides. Traffic 2007; 8:848-66.
27. Savina A, Amigorena S. Phagocytosis and antigen presentation in dendritic cells Immunol Rev 2007; 219:143-56.