The expression of serum steroid sex hormones and steroidogenic enzymes following intraperitoneal administration of dehydroepiandrosterone (DHEA) in male rats

Steroids

Volumn 75, Issue 3, 2010, Pages 213-218

  Song, Lijie ^a   Tang, Xue ^b   Kong, Yili ^a   Ma, Haitian ^a   Zou, Sixiang ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

DHEA; Key enzymes; Male rats; Metabolism

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; BETA ACTIN; CHOLESTEROL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 17; ESTRADIOL; HYDROCORTISONE; MESSENGER RNA; PRASTERONE; PRASTERONE SULFATE; PROGESTERONE; SEX HORMONE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE;

ALDOSTERONE BLOOD LEVEL; ANDROGEN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME ASSAY; ENZYME BLOOD LEVEL; ENZYME SYNTHESIS; ESTRADIOL BLOOD LEVEL; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HORMONAL THERAPY; HORMONE DETERMINATION; HORMONE SYNTHESIS; HYDROCORTISONE BLOOD LEVEL; MALE; NONHUMAN; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; RAT; SEX HORMONE DETERMINATION; TESTOSTERONE BLOOD LEVEL;

17-HYDROXYSTEROID DEHYDROGENASES; 3-HYDROXYSTEROID DEHYDROGENASES; ANIMALS; CHOLESTEROL; CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; GONADAL STEROID HORMONES; INJECTIONS, INTRAPERITONEAL; MALE; PHOSPHOPROTEINS; RANDOM ALLOCATION; RATS; STEROID 17-ALPHA-HYDROXYLASE;

ANIMALIA; PRIMATES; RATTUS;

EID: 76349095128     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2009.11.007     Document Type: Article

References (27)

1. Labrie F., Bélanger A., Luu-The V., Simard J., Lin S.X., Cusan L., et al. Role of DHEA transformation into androgens and estrogens in peripheral intracrine tissues. In: Thijssen J.H.H., and Nieuwenhuyse H. (Eds). Proceedings of the workshop on DHEA: a comprehensive review (1999), Amsterdam, Parthenon Publishing, New York 69-103
2. Perret M., and Aujard F. Aging and season affect plasma dehydroepiandrosterone sulfate (DHEA-S) levels in a primate. Exp Gerontol 40 (2005) 582-587
3. Aoki K., Taniguchi H., Ito Y., Satoh S., Nakamura S., Muramatsu K., et al. Dehydroepiandrosterone decreases elevated hepatic glucose production in C57BL/KsJ-db/db mice. Life Sci 74 (2004) 3075-3084
4. Migeon C.J., Keller A.R., Lawernce B., and Shepart Ii T.H. Dehydroepiandrosterone and androsterone levels in human placenta. Effect of age and sex: day-to-day and diurnal variations. Clin Endocrinol Metab 17 (1957) 1051-1062
5. Labrie F., Luu-The V., Labrie C., and Simard J. DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol 22 (2001) 185-212
6. Arlt W., Justl H.G., Callies F., Reincke M., Hübler D., Oettel M., et al. Oral dehydroepiandrosterone for adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression. J Clin Endocrinol Metab 83 (1998) 1928-1934
7. Arlt W., Haas J., Callies F., Reincke M., Hübler D., Oettel M., et al. Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab 84 (1999) 2170-2176
8. Labrie F., Bélanger A., Cusan L., and Candas B. Physiological changes in dehydroepiandrosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology. J Clin Endocrinol Metab 82 (1997) 2403-2409
9. Berger L., El-Alfy M., Martel C., and Labrie F. Effects of dehydroepiandrosterone. Premarin and acolbifene on histomorphology and sex steroid receptors in the rat vagina. J Steroid Biochem Mol Biol 96 (2005) 201-215
10. Zhu Y.M., Miao J.F., Fan H.J., Zou S.X., and Chen W.H. Protective effect of CpG-DNA against mastitis induced by Staphylococcus aureus infection in a rat model. J Int Immunopharmacol 7 (2007) 435-443
11. Zhao H.F., Labrie C., Simard J., de Launoit Y., Trudel C., Martel C., et al. Characterization of rat 3 beta-hydroxysteroid dehydrogenase/delta 5-delta-4 isomerase cDNAs and differential tissue-specific expression of the corresponding mRNAs in steroidogenic and peripheral tissues. J Biol Chem 266 (1991) 583-593
12. Namiki M., Kitamura M., Buczko E., and Dufau M.L. Rat testis P450-17a cDNA: the deduced amino acid sequence, expression and secondary structural configuration. J Biochem Biophys Res Commun 157 (1988) 705-712
13. Kumar V., Chakraborty A., Viswanath G., and Roy P. Androgenic endocrine disruptors in wastewater treatment plant effluents in India: their influence on reproductive processes and systemic toxicity in male rats. J Toxicol Appl Pharmacol 226 (2008) 60-73
14. Ryu J.Y., Lee B.M., Kacew S., and Kim H.S. Identification of differentially expressed genes in the testis of Sprague-Dawley rats treated with di (n-butyl) phthalate. J Toxicol 234 (2007) 103-112
15. Longcope C. Metabolism of dehydroepiandrosterone. Ann NY Acad Sci 774 (1995) 143-147
16. Payne A.H., and Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. J Endocr Rev 25 (2004) 947-970
17. Leblanc M., Labrie C., Bélanger A., Candas B., and Labrie F. Pharmacokinetics of oral dehydroepiandrosterone (DHEA) in the ovariectomised cynomolgus monkey. J Steroid Biochem Mol Biol 81 (2002) 159-164
18. Labrie F., Bélanger A., Bélanger P., Bérubé R., Martel C., Cusan L., et al. Metabolism of DHEA in postmenopausal women following percutaneous administration. J Steroid Biochem Mol Biol 103 (2007) 178-188
19. Zumoff B., Strain G.W., Miller L.K., and Rosner W. Twenty-four-hour mean plasma testosterone concentration declines with age in normal premenopausal women. J Clin Endocrinol Metab 80 (1995) 1429-1430
20. Valenti G., Banchini A., Denti L., Maggio H., Ceressini C., and Ceda G.P. Acute oral administration of dehydroepiandrosterone in male subjects: effects of age and bioconversion in other steroids. J Endocrinol Invest 22 (1999) 24-28
21. Longcope C., Bourget C., and Flood C. The production and aromatization of DHEA in post-menopausal women. J Clin Endocrinol Metab 71 (1982) 325-332
22. Frye R.F., Kroboth P.D., Kroboth F.J., Stone R.A., Folan M., Salek F.S., et al. Sex differences in the pharmacokinetics of dehydroepiandrosterone (DHEA) after single- and multiple-dose administration in healthy older adults. J Clin Pharmacol 40 (2000) 596-605
23. Mortola J.F., and Yen S.S. The effects of oral dehydroepiandrosterone on endocrine-metabolic parameters in post-menopausal women. J Clin Endocrinol Metab 71 (1990) 696-704
24. Arlt W., Haas J., Callies F., Reincke M., Hubler D., Oettel M., et al. Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab 84 (1999) 2170-2176
25. Burstein S., and Gut M. Intermediates in the conversion of cholesterol to pregnenolone: kinetics and mechanism. J Steroids 28 (1976) 125-131
26. Richards R.J., Porter J.R., and Svec F. Serum leptin, lipids, free fatty acids and fat-pads in long-term dehydroepiandrosterone-treated Zucker rats. J Proc Soc Exp Biol Med 223 (2000) 258-262
27. Albrecht E.D., Aberdeen G.W., and Pepe G.J. Estrogen elicits cortical zone specific effects on development of the primate fetal adrenal gland. J Endocrinol 146 (2004) 1737-1744