Coincident expression of Β-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomas

Modern Pathology

Volumn 23, Issue 2, 2010, Pages 225-234

  Kurihara, Shuichi ^a   Oda, Yoshinao ^a   Ohishi, Yoshihiro ^a   Kaneki, Eisuke ^a   Kobayashi, Hiroaki ^a   Wake, Norio ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

catenin; Cyclin D1; Endometrial stromal tumor; Wnt signaling pathway

Indexed keywords

BETA CATENIN; CYCLIN D1; MATRILYSIN; WNT PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOMETRIAL STROMAL TUMOR; ENDOMETRIUM SARCOMA; GENE; GENE MUTATION; GENE TARGETING; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; METHYLATION; PLEOMORPHIC ADENOMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UNDIFFERENTIATED CARCINOMA; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CELL NUCLEUS; CYCLIN D1; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; ENDOMETRIAL NEOPLASMS; FEMALE; GENES, APC; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MATRIX METALLOPROTEINASE 7; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SARCOMA, ENDOMETRIAL STROMAL; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 76349089320     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.162     Document Type: Article

References (34)

1. Hendrickson MR, Tavassoli FA, Kempson RL, et al. Mesenchymal tumours and related lesions. In: Tavas-soli FA, Devilee P (eds). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press: Lyon, France, 2003, pp 233-244.
2. Kurihara S, Oda Y, Ohishi Y, et al. Endometrial stromal sarcomas and related high-grade sarcomas: immuno-histochemical and molecular genetic study of 31 cases. Am J Surg Pathol 2008;32:1228-1238.
3. Ilyas M. Wnt signalling and the mechanistic basis of tumour development. J Pathol 2005;205:130-144.
4. Ng TL, Gown AM, Barry TS, et al. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol 2005;18:68-74.
5. Saito T, Oda Y, Sakamoto A, et al. Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of beta-catenin mutations in synovial sarcoma. J Pathol 2000;192: 342-350.
6. Saito T, Oda Y, Tanaka K, et al. Beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours. J Pathol 2001;195:222-228.
7. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-426.
8. Brabletz T, Jung A, Dag S, et al. b-Catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am J Pathol 1999;155:1033-1038.
9. Matono H, Oda Y, Nakamori M, et al. Correlation between beta-catenin nuclear expression and matrix metalloproteinase-7 overexpression in sporadic des-moid tumors. Hum Pathol 2008;39:1802-1808.
10. Deryugina EI, Quigley JP. Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 2006; 25:9-34.
11. Ii M, Yamamoto H, Adachi Y, et al. Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis. Exp Biol Med 2006;231:20-27.
12. Lee AY, He B, You L, et al. Expression of the secreted frizzled-protein gene family is downregulated in human mesothelioma. Oncogene 2004;23:6672-6676.
13. He B, Lee AY, Dadfarmay S, et al. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in b-catenin-deficient human me-sothelioma cells. Cancer Res 2005;65:743-748.
14. Liu TH, Raval A, Chen SS, et al. CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia. Cancer Res 2006;66:653-658.
15. Hrzenjak A, Tippl M, Kremser ML, et al. Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas. J Pathol 2004;204:19-27.
16. Silverberg SG, Kurman RJ. Endometrial stromal tumors. In: Silverberg SG, Kurman RJ (eds). Atlas of Tumor Pathology. Tumors of the Uterine Corpus and Gestational Trophoblastic Disease. Third Series, Fascicle 3. Armed Forces Institute of Pathology: Washington, DC, 1992, pp 91-112.
17. Iwao K, Nakamori S, Kameyama M, et al. Activation of the b-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations. Cancer Res 1998;58:1021-1026.
18. Yagi OK, Akiyama Y, Ohkura Y, et al. Analyses of the APC and TGF-beta type II receptor genes, and micro-satellite instability in mucosal colorectal carcinomas. Jpn J Cancer Res 1997;88:718-724.
19. Zou H, Molina JR, Harrington JJ, et al. Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. Int J Cancer 2005;115:584-591.
20. Koontz JI, Soreng AL, Nucci M, et al. Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci USA 2001;98:6348-6353.
21. Ewen ME, Lamb J. The activities of cyclin D1 that drive tumorigenesis. Trends Mol Med 2004;10:158-162.
22. Wang HL, Wang J, Xiao SY, et al. Elevated protein expression of cyclin D1 and fra-1 but decreased expression of c-myc in human colorectal adenocarcinomas overexpressing b-catenin. Int J Cancer 2002;101:301-310.
23. Lin SY, Xia W, Wang JC, et al. Beta catenin, a novel prognostic marker for breast cancer: its roles in cyclin d1 expression and cancer progression. Proc Natl Acad Sci USA 2000;97:4262-4266.
24. Lantsov D, Meirmanov S, Nakashima M, et al. Cyclin D1 overexpression in thyroid papillary microcarcino-ma: its association with tumour size and aberrant beta-catenin expression. Histopathology 2005;47:248-256.
25. Alao J. The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention. Mol Cancer 2007;6:24.
26. Jung CK, Jung JH, Lee A, et al. Diagnostic use of nuclear b-catenin expression for the assessment of endometrial stromal tumors. Mod Pathol 2008;21:756-763.
27. Micci F, Heim S. Pathogenetic mechanisms in endo-metrial stromal sarcoma. Cytogenet Genome Res 2007;118:190-195.
28. Nucci MR, Harburger D, Koontz J, et al. Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J Surg Pathol 2007;31: 65-70.
29. Oliva E, Leval L, Soslow RA, et al. High frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal tumors with smooth muscle differentiation by inter-phase FISH detection. Am J Surg Pathol 2007;31: 1277-1284.
30. Hrzenjak A, Moinfar F, Tavassoli FA, et al. JAZF1/ JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase- polymer-ase chain reaction optimized for paraffin-embedded tissue. J Mol Diagn 2005;7:388-395.
31. Huang HY, Ladanyi M, Soslow RA. Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. Am J Surg Pathol 2004;28:224-232.
32. Zaloudek C, Hendrickson MR. Mesenchymal tumors of the uterus. In: Kurman RJ (ed). Blaustein's Pathology of the Female Genital Tract. 5th edn. Springer-Verlag: New York, 2002, pp 583-593.
33. Micci F, Walter CU, Teixeira MR, et al. Cytogenetic and molecular genetic analyses of endometrial stromal sarcoma: nonrandom involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). Cancer Genet Cytogenet 2003;144:119-124.
34. Zhu XQ, Shi YF, Cheng XD, et al. Immunohistochem-ical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. Gynecol Oncol 2004;92:71-79.