Detection of initiation activity of 1,2-dimethylhydrazine in in vivo medium-term liver initiation assay system using 4-week-old rats without hepatocellular proliferative stimuli during the test chemical treatment period

Journal of Veterinary Medical Science

Volumn 72, Issue 1, 2010, Pages 43-53

  Asaoka, Yoshiji ^a,b   Sakai, Hiroki ^a,c   Hirata, Akihiro ^d   Sasaki, Jun ^a,e   Goryo, Masanobu ^b,e   Miyamoto, Yohei ^b   Yanai, Tokuma ^a,c   Masegi, Toshiaki ^a,c   Okada, Kosuke ^a,e  

^a GIFU UNIVERSITY   (Japan)

^b TORAY INDUSTRIES INC   (Japan)

^c GIFU UNIVERSITY   (Japan)

^d GIFU UNIVERSITY   (Japan)

^e IWATE UNIVERSITY   (Japan)

Author keywords

1,2 dimethylhydrazine (DMH)introduction; Carcinogenesis; GST p positive cell foci; Liver; Rat

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CYTOCHROME P450;

ANIMAL; ARTICLE; CARCINOGEN TESTING; CELL PROLIFERATION; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; DRUG EFFECT; FISCHER 344 RAT; LIVER CELL; LIVER TUMOR; MALE; METABOLISM; METHODOLOGY; PHYSIOLOGY; PRECANCER; RAT;

1,2-DIMETHYLHYDRAZINE; ANIMALS; CARCINOGENICITY TESTS; CELL PROLIFERATION; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; LIVER NEOPLASMS, EXPERIMENTAL; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344;

ANIMALIA; RATTUS;

EID: 76349088521     PISSN: 09167250     EISSN: 13477439     Source Type: Journal    
DOI: 10.1292/jvms.09-0297     Document Type: Article

References (56)

1. Ames, B. and Gold, L. 1998. The causes and prevention of cancer: the role of environment. Biotherapy 11: 205-220.
2. Asaoka, Y., Sakai, H., Takahashi, N., Hirata, A., Tsukamoto, T., Yamamoto, M., Yanai, T., Masegi, T. and Tatematsu, M. 2005. Intraperitoneal injection of D-galactosamine provides a potent cell proliferation stimulus for the detection of initiation activities of chemicals in rat liver. J. Appl. Toxicol. 25: 554-561.
3. Bandiera, S., Ryan, D., Levin, W. and Thomas, P. 1986. Age- and sex-related expression of cytochromes p450f and P450g in rat liver. Arch. Biochem. Biophys. 248: 658-676.
4. Burke, M., Thompson, S., Weaver, R., Wolf, C. and Mayer, R. 1994. Cytochrome P450 specificities of alkoxyresorufin O- dealkylation in human and rat liver. Biochem. Pharmacol. 48: 923-936.
5. Cayama, E., Tsuda, H., Sarma, D. and Farber, E. 1978. Initiation of chemical carcinogenesis requires cell proliferation. Nature 275: 60-62.
6. Cohen, S. and Ellwein, L. 1990. Cell proliferation in carcinogenesis. Science 249: 1007-1011.
7. Constan, A., Yang, R., Baker, D. and Benjamin, S. 1995. A unique pattern of hepatocyte proliferation in F344 rats following long-term exposures to low levels of a chemical mixture of groundwater contaminants. Carcinogenesis 16: 303-310.
8. Elbarbry, F., McNamara, P. and Alcorn, J. 2007. Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat. J. Biochem. Mol. Toxicol. 21: 41-50.
9. Espandiari, P., Robertson, L.W., Srinivasan, C. and Glauert, H.P. 2005. Comparison of different initiation protocols in the resistant hepatocyte model. Toxicology 206: 373-381.
10. Farber, E., Hartman, S.P., Solt, D. and Cameron, R. 1976. Precancerous Liver Cell Populations and Their Identification. University Park Press, Baltimore.
11. Fiala, E. 1977. Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer 40: 2436-2445.
12. Furukawa, S., Tamura, T., Ogawa, I., Goryo, M. and Okada, K. 2003. Effect of juvenile aging hepatocellular proliferation in male Han Wistar (GALAS) rats. J. Toxicol. Pathol. 16: 81-84.
13. Gad, S.C. 2001. Human pharmaceutical products. pp. 9-69. In: Regulatory Toxicology (Gad, S.C. ed.). Taylor & Francis, London.
14. Gerhardsson, de Verdier M., Hagman, U., Peters, R., Steineck, G. and Overvik, E. 1991. Meat, cooking methods and colorectal cancer: a case-referent study in Stockholm. Int. J. Cancer 49: 520-525.
15. Goldsworthy, T., Hanigan, M. and Pitot, H. 1986. Models of hepatocarcinogenesis in the rat--contrasts and comparisons. Crit. Rev. Toxicol. 17: 61-89.
16. Goldsworthy, T. and Pitot, H. 1985. An approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver. J. Toxicol. Environ. Health 16: 389-402.
17. Grasl-Kraupp, B., Luebeck, G., Wagne, A., Löw-Baselli, A., de Gunst, M., Waldhör, T., Moolgavkar, S. and Schulte-Hermann, R. 2000. Quantitative analysis of tumor initiation in rat liver: Role of cell replication and cell death (apoptosis). Carcinogenesis 21: 1411-1421.
18. Guengerich, F. 2000. Metabolism of chemical carcinogens. Carcinogenesis 21:345-351.
19. Hirata, A., Tsukamoto, T., Sakai, H., Takasu, S., Ban, H., Imai, T., Totsuka, Y., Nishigaki, R., Wakabayashi, K., Yanai, T., Masegi, T. and Tatematsu, M. 2008. Carcinogenic risk of heterocyclic amines in combination - Assessment with a liver initiation model. Food Chem. Toxicol. 46: 2003-2009.
20. Hsu, S., Raine, L. and Fanger, H. 1981. Use of avidin-biotinperoxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J. Histochem. Cytochem. 29: 577-580.
21. Imaoka, S., Fujita, S. and Funae, Y. 1991. Age-dependent expression of cytochrome P-450s in rat liver. Biochim. Biophys Acta 1097: 187-192.
22. Ito, N., Shirai, T. and Fukushima, S. 1991. Medium-term bioassay for carcinogens using multiorgan models. Prog. Exp. Tumor. Res. 33: 41-57.
23. Ito, N., Tamano, S. and Shirai, T. 2003. A medium-term rat liver bioassay for rapid in vivo detection of carcinogenic potential of chemicals. Cancer Sci. 94: 3-8.
24. Ito, N., Tsuda, H., Tatematsu, M., Inoue, T., Tagawa, Y., Aoki, T., Uwagawa, S., Kagawa, M., Ogiso, T. and Masui, T. 1988. Enhancing effect of various hepatocarcinogens on induction of preneoplastic glutathione S-transferase placental form positive foci in rats--an approach for a new medium-term bioassay system. Carcinogenesis 9: 387-394.
25. Itoh, T., Moto, M., Takahashi, M., Sakai, H. and Mitsumori, K. 2006. Liver initiation activity of norfloxacin but not nalidixic acid, pipemidic acid, and ciprofloxacin on in vivo short-term liver initiation assay in rats. Toxicology 222: 240-246.
26. Kato, R. and Yamazoe, Y. 1992. Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity. Toxicol. Lett. 64-65 Spec No:661-667.
27. Kobayashi, K., Mutai, M., Goto, K., Inada, K., Tsukamoto, T., Nakanishi, H. and Tatematsu, M. 1997. Effects of carbon tetrachloride administration on initiation of liver cell foci by the non-hepatocarcinogens N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and benzo(a)pyrene (B(a)P). Cancer Lett. 118: 55-60.
28. Leclercq, I., Horsmans, Y. and Desager, J. 1998. Estimation of chlorzoxazone hydroxylase activity in liver microsomes and of the plasma pharmacokinetics of chlorzoxazone by the same high-performance liquid chromatographic method. J. Chromatogr. 828: 291-296.
29. Löw-Baselli, A., Hufnagl, K., Parzefall, W., Schulte-Hermann, R. and Grasl-Kraupp, B. 2000. Initiated rat hepatocytes in primary culture: a novel tool to study alterations in growth control during the first stage of carcinogenesis. Carcinogenesis 21: 79-86.
30. Moore, M., Nakagawa, K. and Ishikawa, T. 1988. Selection pressure and altered hepatocellular islands after a single injection of aflatoxin B1. Jpn. J. Cancer Res. 79: 187-194.
31. Moore, M., Nakagawa, K., Satoh, K., Ishikawa, T. and Sato, K. 1987. Single GST-P positive liver cells--putative initiated hepatocytes. Carcinogenesis 8: 483-486.
32. Ogiso, T., Tatematsu, M., Tamano, S., Tsuda, H. and Ito, N. 1985. Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a longterm assay. Toxicol. Pathol. 13: 257-265.
33. Okamura, M., Sakai, H., Takahashi, N., Inagami, A., Tsukamoto, T., Yamamoto, M., Shirai, N., Iidaka, T., Yanai, T., Masegi, T. and Tatematsu, M. 2002. The effects of allyl alcohol- induced cell proliferation for detection of initiation activities of chemicals in rat liver. J. Toxicol. Pathol. 15: 95-102.
34. Omura, T. and Sato, R. 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239: 2370-2378.
35. Parton, J. and Garriott, M. 1997. An evaluation of micronucleus induction in bone marrow and in hepatocytes isolated from collagenase perfused liver or from formalin-fixed liver using four-week-old rats treated with known clastogens. Environ. Mol. Mutagen. 29: 379-385.
36. Pearce, R., McIntyre, C., Madan, A., Sanzgiri, U., Draper, A., Bullock, P., Cook, D., Burton, L., Latham, J., Nevins, C. and Parkinson, A. 1996. Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity. Arch. Biochem. Biophys. 331: 145-169.
37. Sakai, H., Tsukamoto, T., Yamamoto, M., Hirata, A., Inagami, A., Shirai, N., Iidaka, T., Yanai, T., Masegi, T. and Tatematsu, M. 2002a. Summation of initiation activities in the liver after partial hepatectomy. Cancer Lett. 176: 1-5.
38. Sakai, H., Tsukamoto, T., Yamamoto, M., Kobayashi, K., Yuasa, H., Imai, T., Yanai, T., Masegi, T. and Tatematsu, M. 2002b. Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity. Cancer Lett. 188: 33-38.
39. Sakai, H., Tsukamoto, T., Yamamoto, M., Shirai, N., Iidaka, T., Yanai, T., Masegi, T. and Tatematsu, M. 2001. Differential effects of partial hepatectomy and carbon tetrachloride administration on induction of liver cell foci in a model for detection of initiation activity. Jpn. J. Cancer Res. 92: 1018-1025.
40. Sakai, H., Tsukamoto, T., Yamamoto, M., Yanai, T., Masegi, T., Inada, K., Nakanishi, H. and Tatematsu, M. 2000. Summation of initiation activities of low doses of the non-hepatocarcinogen 1,2-dimethylhydrazine in the liver after carbon tetrachloride administration. Cancer Lett. 148: 59-63.
41. Sakai, H., Inagami, A., Hirata, A., Tsukamoto, T., Kobayashi, K., Degawa, M., Shirai, N., Iidaka, T., Yanai, T., Masegi, T. and Tatematsu, M. 2002c. The effects of D-galactosamine-or carbon tetrachloride-induced regeneration on induction of rat liver cell foci in a model for detection of initiation activities of chemicals. J. Toxicol. Pathol. 15: 13-18.
42. Schenkman, J., Thummel, K. and Favreau, L. 1989. Physiological and pathophysiological alterations in rat hepatic cytochrome P-450. Drug Metab. Rev. 20: 557-584.
43. Shimada, M., Murayama, N., Yamazoe, Y., Hashimoto, H., Ishikawa, H. and Kato, R. 1995. Age- and sex-related alterations of microsomal drug- and testosterone-oxidizing cytochrome P450 in Sprague-Dawley strain-derived dwarf rats. J. Pharmacol. Exp. Ther. 275: 972-977.
44. Sohn, O., Ishizaki, H., Yang, C. and Fiala, E. 1991. Metabolism of azoxymethane, methylazoxymethanol and N- nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 12: 127-131.
45. Suzuki, H., Shirotori, T. and Hayashi, M. 2004. A liver micronucleus assay using young rats exposed to diethylnitrosamine: Methodological establishment and evaluation. Cytogenet. Genome Res. 104: 299-303.
46. Takasu, S., Tsukamoto, T., Hirata, A., Kawai, K., Toyoda, T., Ban, H., Sakai, H., Yanai, T., Masegi, T., Kasai, H. and Tatematsu, M. 2007. Lack of initiation activity of 4-oxo-2-hexenal, a peroxidation product generated from omega-3 polyunsaturated fatty acids, in an in vivo five-week liver assay. Asian Pac. J. Cancer Prev. 8: 372-374.
47. Tatematsu, M., Hasegawa, R., Imaida, K., Tsuda, H. and Ito, N. 1983. Survey of various chemicals for initiating and promoting activities in a short-term in vivo system based on generation of hyperplastic liver nodules in rats. Carcinogenesis 4: 381-386.
48. Tatematsu, M., Mera, Y., Ito, N., Satoh, K. and Sato, K. 1985. Relative merits of immunohistochemical demonstrations of placental, A, B and C forms of glutathione S-transferase and histochemical demonstration of gamma-glutamyl transferase as markers of altered foci during liver carcinogenesis in rats. Carcinogenesis 6: 1621-1626.
49. Tatematsu, M., Miyata, Y., Mizutani, M., Hananouchi, M. and Hirose, M. 1977. Summation effect of N-butyl-n-4-hydroxyburtylnitrosamine, N-4-5-nitro-2-furyl-2-thiazolyformamide, N-2- fluoroenylacetamide, and 3,3'-dichlorobenzidine on urinary bladder carcinogenesis in rats. Gann 68: 193-202.
50. Tezuka, N., Tada, M., Kojima, M., Nakanishi, H., Mori, A. and Tatematsu, M. 1995. Effects of partial hepatectomy on initiation of liver cell foci by 4-nitroquinoline 1-oxide, a non-hepatocarcinogen, and generation of DNA adducts in rats. Cancer Lett. 89: 89-94.
51. Thomas, P., Bandiera, S., Maines, S., Ryan, D. and Levin, W. 1987. Regulation of cytochrome P-450j, a high-affinity N- nitrosodimethylamine demethylase, in rat hepatic microsomes. Biochemistry 26: 2280-2289.
52. Thurnherr, N., Deschner, E., Stonehill, E. and Lipkin, M. 1973. Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res. 33: 940-945.
53. Tsuda, H., Lee, G. and Farber, E. 1980. Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res. 40: 1157-1164.
54. van der Hoeven, T. and Coon, M. 1974. Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes. J. Biol. Chem. 249: 6302-6310.
55. Ward, J., Yamamoto, R., Benjamin, T., Brown, C. and Weisburger, J. 1974. Experimentally induced cancer of the colon in rats and mice. J. Am. Vet. Med. Assoc. 164: 729-732.
56. Whalley, P., Bakes, D., Grime, K. and Weaver, R. 2001. Rapid high-performance liquid chromatographic method for the separation of hydroxylated testosterone metabolites. J. Chromatogr. B. Biomed. Sci. Appl. 760: 281-288.