Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 1, 2010, Pages 442-447

  Tresguerres, Martin ^a,b   Parks, Scott K ^b,c   Salazar, Eric ^a   Levin, Lonny R ^a   Goss, Greg G ^b,c   Buck, Jochen ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BAMFIELD MARINE SCIENCES CENTRE   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

cAMP; Dogfish; Gill; pH; Proton pump

Indexed keywords

ADENYLATE CYCLASE; BICARBONATE; CYCLIC AMP; PROTON;

ACID BASE BALANCE; ANIMAL TISSUE; ARTICLE; BASOLATERAL MEMBRANE; CELL STRESS; CONTROLLED STUDY; DOGFISH; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; EPITHELIUM; GILL; HOMEOSTASIS; MAMMAL; METAZOON; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGANISM; ORTHOLOGY; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECOND MESSENGER; SECRETORY CELL; SENSOR; SHARK;

ACID-BASE EQUILIBRIUM; ADENYLATE CYCLASE; ALKALOSIS; ANIMALS; BICARBONATES; DOGFISH; GILLS; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; PHYLOGENY;

ANIMALIA; CHONDRICHTHYES; MAMMALIA; METAZOA; SQUALUS ACANTHIAS;

EID: 76249129622     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0911790107     Document Type: Article

References (35)

1. Buck J, Sinclair ML, Schapal L, Cann MJ, Levin LR (1999) Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci USA 96:79-84.
2. Chen Y, et al. (2000) Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science 289:625-628.
3. Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR (2003) Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem 278:15922-15926.
4. Zippin JH, et al. (2004) Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. J Cell Biol 164:527-534.
5. Hess KC, et al. (2005) The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell 9:249-259.
6. Xie F, et al. (2006) Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization. Dev Biol 296:353-362.
7. Pastor-Soler N, et al. (2003) Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem 278 (1):49523-49529.
8. Schmid A, et al. (2007) Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol 130 (1):99-109.
9. Miller RF, Cloutier R, Turner S (2003) The oldest articulated chondrichthyan from the Early Devonian period. Nature 425:501-504.
10. Heisler N (1988) Physiology of Elasmobranch Fishes, ed Shuttleworth TJ (Springer, Berlin), pp 215-252.
11. Piermarini PM, Verlander JW, Royaux IE, Evans DH (2002) Pendrin immunoreactivity in the gill epithelium of a euryhaline elasmobranch. Am J Physiol 283:R983-R992.
12. Tresguerres M, Katoh F, Fenton H, Jasinska E, Goss GG (2005) Regulation of branchial V-H(+)-ATPase, Na(+)/K(+)-ATPase and NHE2 in response to acid and base infusions in the Pacific spiny dogfish (Squalus acanthias). J Exp Biol 208:345-354.
13. +-ATPase to the basolateral membrane in the Pacific spiny dogfish (Squalus acanthias): A role in base secretion. J Exp Biol 209:599-609.
14. +-ATPase translocation during blood alkalosis in dogfish gills: Interaction with carbonic anhydrase and involvement in the postfeeding alkaline tide. Am J Physiol 292:R2012-R2019.
15. Wood CM, Kajimura M, Mommsen TP, Walsh PJ (2005) Alkaline tide and nitrogen conservation after feeding in an elasmobranch (Squalus acanthias). J Exp Biol 208:2693-2705.
16. Wood CM, Schultz AG, Munger RS, Walsh PJ (2009) Using omeprazole to link the components of the post-prandial alkaline tide in the spiny dogfish, Squalus acanthias. J Exp Biol 212:684-692.
17. Kobayashi M, Buck J, Levin LR (2004) Conservation of functional domain structure in bicarbonate-regulated "soluble" adenylyl cyclases in bacteria and eukaryotes. Dev Genes Evol 214:503-509.
18. Chaloupka JA, Bullock SA, Iourgenko V, Levin LR, Buck J (2006) Autoinhibitory regulation of soluble adenylyl cyclase. Mol Reprod Dev 73:361-368.
19. Braun T (1991) Purification of soluble form of adenylyl cyclase from testes. Methods Enzymol 195:130-136.
20. Neer EJ, Murad F (1979) Separation of soluble adenylate and guanylate cyclases from the mature rat testis. Biochim Biophys Acta 583:531-534.
21. Beltrán C, et al. (2007) Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. Biochem Biophys Res Commun 358:1128-1135.
22. Steegborn C, et al. (2005) A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem 280:31754-31759.
23. Gilmour KM, Bayaa M, Kenney L, McNeill B, Perry SF (2007) Type IV carbonic anhydrase is present in the gills of spiny dogfish (Squalus acanthias). Am J Physiol 292:R556-R567.
24. Paunescu TG, et al. (2008) Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. Am J Physiol Renal Physiol 294:F130-F138.
25. + transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem 284:5774-5783.
26. +)-ATPase. Nat Med 2:470-472.
27. +-ATPase recycling. J Biol Chem 280:8452-8463.
28. +-ATPase. Physiol Rev 84:1263-1314.
29. Okech BA, Boudko DY, Linser PJ, Harvey WR (2008) Cationic pathway of pH regulation in larvae of Anopheles gambiae. J Exp Biol 211:957-968.
30. 2 excretion in fish: unanswered questions and emerging models. Respir Physiol Neurobiol 154:199-215.
31. Anderson WG, et al. (2007) Body fluid volume regulation in elasmobranch fish. Comp Biochem Physiol A Physiol 148 (1):3-13.
32. Cameron JN (1971) Rapid method for determination of total carbon dioxide in small blood samples. J Appl Physiol 31:632-634.
33. Boutilier RG, Heming TA, Iwama GK (1984) Fish Physiology, eds Hoar WS, Randall AD (Academic, Orlando, FL) . 10A, pp 403-430.
34. Larkin MA, et al. (2007) Clustal W and Clustal X version 2. Bioinformatics 23:2947-2948.
35. Guindon S, Gascuel O (2003) A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 52:696-704.