Direct effects of K ATP channel openers pinacidil and diazoxide on oxidative phosphorylation of mitochondria in situ

Cellular Physiology and Biochemistry

Volumn 25, Issue 2-3, 2010, Pages 181-186

  Kopustinskiene, Dalia M ^a   Liobikas, Julius ^a   Skemiene, Kristina ^a,b   Malinauskas, Faustas ^a   Toleikis, Adolfas ^a  

^a KAUNAS UNIVERSITY OF MEDICINE   (Lithuania)

^b VYTAUTAS MAGNUS UNIVERSITY   (Lithuania)

Author keywords

Diazoxide; Mitochondria in situ; Oxidative phosphorylation; Pinacidil; Skinned cardiac fibers; Uncoupling

Indexed keywords

DIAZOXIDE; MALIC ACID; PINACIDIL; POTASSIUM CHANNEL; PYRUVIC ACID;

ANIMAL TISSUE; ARTICLE; BREATHING RATE; CONTROLLED STUDY; HEART MITOCHONDRION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; ISCHEMIC PRECONDITIONING; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SKINNED MUSCLE FIBER;

RATTUS;

EID: 76249127918     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000276552     Document Type: Article

References (45)

1. Szewczyk A, Skalska J, Glab M, Kulawiak B, Malinska D, Koszela-Piotrowska I, Kunz WS: Mitochondrial potassium channels: from pharmacology to function. Biochim Biophys Acta 2006;1757:715-720.
2. Ardehali H, O'Rourke B: Mitochondrial K(ATP) channels in cell survival and death. J Mol Cell Cardiol 2005;39:7-16. (Pubitemid 40836042)
3. Kane GC, Liu XK, Yamada S, Olson TM, Terzic A: Cardiac KATP channels in health and disease. J Mol Cell Cardiol 2005;38:937-943.
4. Facundo HT, Fornazari M, Kowaltowski AJ: Tissue protection mediated by mitochondrial K+ channels. Biochim Biophys Acta 2006;1762:202-212.
5. Garlid KD, Dos Santos P, Xie ZJ, Costa AD, Paucek P: Mitochondrial potassium transport: the role of the mitochondrial ATP-sensitive K(+) channel in cardiac function and cardioprotection. Biochim Biophys Acta 2003;1606:1-21.
6. Garlid KD, Paucek P: Mitochondrial potassium transport: the K(+) cycle. Biochim Biophys Acta 2003;1606:23-41.
7. Kowaltowski AJ, Seetharaman S, Paucek P, Garlid KD: Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria. Am J Physiol Heart Circ Physiol 2001;280:H649-H657.
8. Hanley PJ, Mickel M, Loffler M, Brandt U, Daut J: K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol 2002;542:735-741.
9. Drose S, Brandt U, Hanley PJ: K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling. J Biol Chem 2006;281:23733-23739.
10. Minners J, Lacerda L, Yellon DM, Opie LH, McLeod CJ, Sack MN: Diazoxide-induced respiratory inhibition-a putative mitochondrial KATP channel independent mechanism of pharmacological preconditioning. Mol Cell Biochem 2007;294:11-18.
11. Costa AD, Quinlan CL, Andrukhiv A, West IC, Jaburek M, Garlid KD: The direct physiological effects of mitoK(ATP) opening on heart mitochondria. Am J Physiol Heart Circ Physiol 2006;290:H406-H415.
12. Halestrap AP: The regulation of the matrix volume of mammalian mitochondria in vivo and in vitro and its role in the control of mitochondrial metabolism. Biochim Biophys Acta 1989;973:355-382.
13. Pain T, Yang XM, Critz SD, Yue Y, Nakano A, Liu GS, Heusch G, Cohen M V, Downey JM: Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals. Circ Res 2000;87:460-466.
14. Vanden Hoek T, Becker LB, Shao ZH, Li CQ, Schumacker PT: Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ Res 2000;86:541-548.
15. Facundo HT, de Paula JG, Kowaltowski AJ: Mitochondrial ATP-sensitive K+ channels are redox-sensitive pathways that control reactive oxygen species production. Free Radic Biol Med 2007;42:1039-1048.
16. Andrukhiv A, Costa AD, West IC, Garlid KD: Opening mitoKATP increases superoxide generation from complex I of the electron transport chain. Am J Physiol Heart Circ Physiol 2006;291:H2067-H2074.
17. Belisle E, Kowaltowski AJ: Opening of mitochondrial K+ channels increases ischemic ATP levels by preventing hydrolysis. J Bioenerg Biomembr 2002;34:285-298.
18. Dzeja PP, Bast P, Ozcan C, Valverde A, Holmuhamedov EL, Van Wylen DG, Terzic A: Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection. Am J Physiol Heart Circ Physiol 2003;284:H1048-H1056.
19. Grimmsmann T, Rustenbeck I: Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria. Br J Pharmacol 1998;123:781-788.
20. Schafer G, Wegener C, Portenhauser R, Bojanovski D: Diazoxide, an inhibitor of succinate oxidation. Biochem Pharmacol 1969;18:2678-2681.
21. Kopustinskiene DM, Jovaisiene J, Liobikas J, Toleikis A: Diazoxide and pinacidil uncouple pyruvate-malate-induced mitochondrial respiration. J Bioenerg Biomembr 2002;34:49-53.
22. Holmuhamedov EL, Jahangir A, Oberlin A, Komarov A, Colombini M, Terzic A: Potassium channel openers are uncoupling protonophores: implication in cardioprotection. FEBS Lett 2004;568:167-170.
23. Veksler VI, Kuznetsov AV, Sharov VG, Kapelko VI, Saks VA: Mitochondrial respiratory parameters in cardiac tissue: a novel method of assessment by using saponin-skinned fibers. Biochim Biophys Acta 1987;892:191-196.
24. Gornall A G, Bardawill CJ, David MM: Determination of serum proteins by means of the biuret reaction. J Biol Chem 1949;177:751-766.
25. Toleikis A, Majiene D, Trumbeckaite S, Dagys A, Jasaitis A: The effect of collagenase and temperature on mitochondrial respiratory parameters in saponin-skinned cardiac fibers. Biosci Rep 1996;16:513-519.
26. Holtzman JL: Calibration of the oxygen polarograph by the depletion of oxygen with hypoxanthine-xanthine oxidase-catalase. Anal Chem 1976;48:229-230.
27. Ovide-Bordeaux S, Ventura-Clapier R, Veksler V: Do modulators of the mitochondrial KATP channel change the function of mitochondria in situ? J Biol Chem 2000;275:37291-37295.
28. Wojtczak L, WOJTCZAK AB: The action of serum albumin on oxidative phosphorylation in insect mitochondria. Biochim Biophys Acta 1959;31:297-299.
29. Grav HJ, Pedersen JI, Christiansen EN: Conditions in vitro which affect respiratory control and capacity for respiration-linked phosphorylation in brown adipose tissue mitochondria. Eur J Biochem 1970;12:11-23.
30. Sellers EM, Koch-Weser J: Binding of diazoxide and other benzothiadiazines to human albumin. Biochem Pharmacol 1974;23:553-566.
31. Groen AK, Wanders RJ, Westerhoff HV, van der MR, Tager JM: Quantification of the contribution of various steps to the control of mitochondrial respiration. J Biol Chem 1982;257:2754-2757.
32. Stucki JW: The optimal efficiency and the economic degrees of coupling of oxidative phosphorylation. Eur J Biochem 1980;109:269-283.
33. Skulachev VP: Uncoupling: new approaches to an old problem of bioenergetics. Biochim Biophys Acta 1998;1363:100-124.
34. Carreira RS, Miyamoto S, Di Mascio P, Goncalves LM, Monteiro P, Providencia LA, Kowaltowski AJ: Ischemic preconditioning enhances fatty acid-dependent mitochondrial uncoupling. J Bioenerg Biomembr 2007;39:313-320.
35. Minners J, van den Bos EJ, Yellon DM, Schwalb H, Opie LH, Sack MN: Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection. Cardiovasc Res 2000;47:68-73.
36. Minners J, Lacerda L, McCarthy J, Meiring JJ, Yellon DM, Sack MN: Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling. Circ Res 2001;89:787-792.
37. Doussiere J, Ligeti E, Brandolin G, Vignais PV: Control of oxidative phosphorylation in rat heart mitochondria. The role of the adenine nucleotide carrier. Biochim Biophys Acta 1984;766:492-500.
38. Schafer G, Portenhauser R, Trolp R: Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide. I. Action on succinate dehydrogenase and TCA-cycle oxidations. Biochem Pharmacol 1971;20:1271-1280.
39. Lembert N, Idahl LA, Ammon HP: K-ATP channel independent effects of pinacidil on ATP production in isolated cardiomyocyte or pancreatic beta-cell mitochondria. Biochem Pharmacol 2003;65:1835-1841.
40. O'Rourke B: Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res 2004;94:420-432.
41. Kane GC, Liu XK, Yamada S, Olson TM, Terzic A: Cardiac KATP channels in health and disease. J Mol Cell Cardiol 2005;38:937-943.
42. Ardehali H, Chen Z, Ko Y, Mejia-Alvarez R, Marban E: Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci USA 2004;101:11880-11885.
43. Jahangir A, Terzic A, Shen WK: Potassium channel openers: therapeutic potential in cardiology and medicine. Expert Opin Pharmacother 2001;2:1995-2010.
44. Das M, Parker JE, Halestrap AP: Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria. J Physiol 2003;547:893-902.
45. Holmuhamedov EL, Wang L, Terzic A: ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. J Physiol (Lond) 1999;519:347-360.