Fenugreek extract rich in 4-hydroxyisoleucine and trigonelline activates PPARα and inhibits LDL oxidation: Key mechanisms in controlling the metabolic syndrome

Natural Product Communications

Volumn 3, Issue 9, 2008, Pages 1509-1513

  Ibarra, Alvin ^a   He, Kan ^a   Bai, Naisheng ^a   Bily, Antoine ^b   Roller, Marc ^b   Coussaert, Aurélie ^c   Provost, Nicolas ^c   Ripoll, Christophe ^d  

^a Naturex Inc   (United States)

^b Givaudan SA   (Switzerland)

^c Genfit SA   (France)

^d Parc Eurasanté   (France)

Author keywords

4 hydroxyisoleucine; Fenugreek; Low density lipoprotein (ldl) oxidation; Metabolic syndrome; Peroxisome proliferator activated receptor alpha (ppar ); Trigonella foenum graecum l; Trigonelline

Indexed keywords

4 HYDROXYISOLEUCINE; COPPER ION; FENOFIBRATE; FENUGREEK EXTRACT; GLUCOSE; HYDROXYLEAN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PLANT EXTRACT; TRIGONELLINE; TROLOX C; UNCLASSIFIED DRUG;

ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENZYME ACTIVATION; FENUGREEK; GLUCOSE BLOOD LEVEL; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; IN VITRO STUDY; LIPID OXIDATION; METABOLIC SYNDROME X; NONHUMAN; RISK REDUCTION; STROKE;

TRIGONELLA FOENUM-GRAECUM;

EID: 76249111312     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0800300923     Document Type: Article

References (24)

1. Hannan JM, Rokeya B, Faruque O, Nahar N, Mosihuzzaman M, Azad Khan AK, Ali L. (2003) Effect of soluble dietary fibre fraction of Trigonella foenum graecum on glycemic, insulinemic, lipidemic and platelet aggregation status of Type 2 diabetic model rats. Journal of Ethnopharmacology, 88, 73-77. (Pubitemid 36945352)
2. Narender T, Puri A, Shweta , Khaliq T, Saxena R, Bhatia G, Chandra R. (2006) 4-Hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent. Bioorganic & Medicinal Chemistry Letters, 16, 293-296. (Pubitemid 41680616)
3. Handa T, Yamaguchi K, Sono Y, Yazawa K. (2005) Effects of fenugreek seed extract in obese mice fed a high-fat diet. Bioscience, Biotechnology, and Biochemistry, 69, 1186-1188. (Pubitemid 41006948)
4. Stark A, Madar Z. (1993) The effect of an ethanol extract derived from fenugreek (Trigonella foenum-graecum) on bile acid absorption and cholesterol levels in rats. The British Journal of Nutrition, 69, 277-287. (Pubitemid 23072719)
5. Venkatesan N, Devaraj SN, Devaraj H. (2007) A fibre cocktail of fenugreek, guar gum and wheat bran reduces oxidative modification of LDL induced by an atherogenic diet in rats. Molecular and Cellular Biochemistry, 294, 145-153. (Pubitemid 46188895)
6. Sharma RD, Raghuram TC, Rao NS. (1990) Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. European Journal of Clinical Nutrition, 44, 301-306.
7. Gupta A, Gupta R, Lal B. (2001) Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. Journal of the Association of Physicians of India, 49, 1057-1061.
8. Broca C, Manteghetti M, Gross R, Baissac Y, Jacob M, Petit P, Sauvaire Y, Ribes G. (2000) 4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion. European Journal of Pharmacology, 390, 339-345.
9. Moorthy R, Prabhu KM, Murthy PS. (1989) Studies on the isolation and effect of an orally active hypoglycemic principle from the seeds of fenugreek (Trigonella foenum graecum). Department of Biochemistry, University College of Medical Sciences, 69-72.
10. Shah SN, Bodhankar SL, Bhonde R, Mohan V. (2006) Hypoglycemic activity of the combination of active ingredients isolated from Trigonella foenum-graecum in alloxan induced diabetic mice. Pharmacologyonline, 1, 65-82.
11. Suganthi R, Rajamani S, Ravichandran MK, Anuradha CV. (2007) Effect of food seasoning spices mixture on biomarkers of oxidative stress in tissues of fructose-fed insulin-resistant rats. Journal of Medicinal Food, 10, 149-153.
12. Thirunavukkarasu V, Anuradha CV, Viswanathan P. (2003) Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytotherapy Research, 17, 737-743.
13. Devasena T, Venugopal Menon P. (2007) Fenugreek seeds modulate 1,2-dimethylhydrazine-induced hepatic oxidative stress during colon carcinogenesis. The Italian Journal of Biochemistry, 56, 28-34.
14. Siddiqui MR, Taha A, Moorthy K, Hussain ME, Basir SF, Baquer NZ. (2005) Amelioration of altered antioxidant status and membrane linked functions by vanadium and Trigonella in alloxan diabetic rat brains. Journal of Biosciences, 30, 483-490. (Pubitemid 41391362)
15. Eckel RH, Grundy SM, Zimmet PZ. (2005) The metabolic syndrome. Lancet, 365, 1415-1428.
16. Bragt MC, Popeijus HE. (2007) Peroxisome proliferator-activated receptors and the metabolic syndrome. Physiology & Behavior, doi:10.1016/j.physbeh. 2007.11.053.
17. Gross B, Staels B. (2007) PPAR agonists: multimodal drugs for the treatment of type-2 diabetes. Best Practice & Research Clinical Endocrinology & Metabolism, 21, 687-710.
18. Staels B, Vu-Dac N, Kosykh VA, Saladin R, Fruchart JC, Dallongeville J, Auwerx J. (1995) Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. Journal of Clinical Investigation, 95, 705-712.
19. Diaz MN, Frei B, Vita JA, Keaney JF. (1997) Antioxidants and atherosclerotic heart disease. New England Journal of Medicine, 337, 408-416.
20. Hirakawa N, Okauchi R, Miura Y, Yagasaki K. (2005) Anti-invasive activity of niacin and trigonelline against cancer cells. Bioscience, Biotechnology, and Biochemistry, 69, 653-658. (Pubitemid 40589132)
21. Tohda C, Nakamura N, Komatsu K, Hattori M. (1999) Trigonelline-induced neurite outgrowth in human neuroblastoma SK-N-SH cells. Biological & Pharmaceutical Bulletin, 22, 679-682.
22. Al-Habori M, Raman A, Lawrence MJ, Skett P. (2001) In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A. International Journal of Experimental Diabetes Research, 2, 91-99.
23. Alcock NW, Crout DHG, Gregorio MVM, Lee E, Pike G, Samuel CJ. (1989) Stereochemistry of the 4-hydroxyisoleucine from Trigonella foenum-graecum. Phytochemistry, 28, 1835-1841.
24. Moore RE, Woolard FX, Sheikh MY, Scheuer PJ. (1978) Isolation and characterization of the first mitotic cycle hormone that regulates cell proliferation. Journal of the American Chemical Society, 100, 7759-7760.