Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporter

Journal of Biological Chemistry

Volumn 285, Issue 3, 2010, Pages 2211-2220

  Herz, Katia ^a   Rimon, Abraham ^a   Olkhova, Elena ^b   Kozachkov, Lena ^c   Padan, Etana ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MAX PLANCK INSTITUTE OF BIOPHYSICS   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE STATE; AMINO ACID RESIDUES; COMPUTATIONAL ANALYSIS; CONSERVED RESIDUES; CYS REPLACEMENT; MEMBRANE VESICLES; MEMBRANE-IMPERMEANT; NEGATIVE CHARGE; PERIPLASM; PH REGULATION; PH RESPONSE; PHYSIOLOGICAL PH; POSITIVELY CHARGED; PRESENCE OF WATER; TRANSMEMBRANE SEGMENTS;

AMINO ACIDS; CHEMICAL MODIFICATION; ESCHERICHIA COLI; ORGANIC ACIDS; PH EFFECTS; POSITIVE IONS;

CRYSTAL STRUCTURE;

ASPARTIC ACID; CATION; CYSTEINE; N ETHYLMALEIMIDE; SODIUM PROTON EXCHANGE PROTEIN; (2 (TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; (2 SULFONATOETHYL)METHANETHIOSULFONATE; (2-(TRIMETHYLAMMONIUM)ETHYL)METHANETHIOSULFONATE; (2-SULFONATOETHYL)METHANETHIOSULFONATE; ESCHERICHIA COLI PROTEIN; LITHIUM; MESYLIC ACID DERIVATIVE; NHAA PROTEIN, E COLI;

ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; ESCHERICHIA COLI; MEMBRANE VESICLE; NONHUMAN; PH; PLASMID; PRIORITY JOURNAL; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; ION TRANSPORT; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ESCHERICHIA COLI;

ASPARTIC ACID; CATIONS; CELL MEMBRANE; COMPUTER SIMULATION; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; HYDROGEN-ION CONCENTRATION; ION TRANSPORT; LITHIUM; MESYLATES; MODELS, MOLECULAR; MUTATION; PERIPLASM; PHENOTYPE; PROTEIN CONFORMATION; SODIUM-HYDROGEN ANTIPORTER;

EID: 76249103944     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.047134     Document Type: Article

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