Function of the vascular endothelial growth factor receptor Flt-1 and Flk-1/KDR in the alloimmune response in vivo

Transplantation

Volumn 80, Issue 6, 2005, Pages 717-722

  Sho, Masayuki ^a   Akashi, Satoru ^a   Kanehiro, Hiromichi ^a   Hamada, Kaoru ^a   Kashizuka, Hisanori ^a   Ikeda, Naoya ^a   Nomi, Takeo ^a   Kuzumoto, Yukiyasu ^a   Tsurui, Yoshikazu ^a   Yoshiji, Hitoshi ^a   Wu, Yan ^b   Hicklin, Daniel J ^b   Briscoe, David M ^c   Nakajima, Yoshiyuki ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b ELI LILLY AND COMPANY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Alloimmunity; Cardiac transplantation; VEGF; VEGFR 1; VEGFR 2

Indexed keywords

CHEMOKINE; CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ACUTE GRAFT REJECTION; ALLOIMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; GENE EXPRESSION REGULATION; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; IN VIVO STUDY; LEUKOCYTE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

ACUTE DISEASE; ANIMALS; CHEMOKINES; CYTOKINES; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; MICE; RNA, MESSENGER; TRANSPLANTATION, HOMOLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 26644435264     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000173650.83320.B1     Document Type: Article

References (28)

1. Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1(1): 27.
2. Leung DW, Cachianes G, Kuang WJ, et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246(4935): 1306.
3. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997; 18(1): 4.
4. Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci 1995; 108 (Pt 6): 2369.
5. Melder RJ, Koenig GC, Witwer BP, et al. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med 1996; 2(9): 992.
6. Marumo T, Schini-Kerth VB, Busse R. Vascular endothelial growth factor activates nuclear factor-kappaB and induces monocyte chemoattractant protein-1 in bovine retinal endothelial cells. Diabetes 1999; 48(5): 1131.
7. Pilmore HL, Eris JM, Painter DM, et al. Vascular endothelial growth factor expression in human chronic renal allograft rejection. Transplantation 1999; 67(6): 929.
8. Shahbazi M, Fryer AA, Pravica V, et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol 2002; 13(1): 260.
9. Reinders ME, Fang JC, Wong W, et al. Expression patterns of vascular endothelial growth factor in human cardiac allografts: association with rejection. Transplantation 2003; 76(1): 224.
10. Lemstrom KB, Krebs R, Nykanen AI, et al. Vascular endothelial growth factor enhances cardiac allograft arteriosclerosis. Circulation 2002; 105(21): 2524.
11. Reinders ME, Sho M, Izawa A, et al. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest 2003; 112(11): 1655.
12. Denton MD, Magee C, Melter M, et al. TNP-470, an angiogenesis inhibitor, attenuates the development of allograft vasculopathy. Transplantation 2004; 78(8): 1218.
13. Sho M, Harada H, Rothstein DM, Sayegh MH. CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy. Transplantation 2003; 75(8): 1142.
14. Sho M, Sandner SE, Najafian N, et al. New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Ann Surg 2002; 236(5): 667.
15. Luttun A, Tjwa M, Moons L, et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002; 8(8): 831.
16. Prewett M, Huber J, Li Y, et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999; 59(20): 5209.
17. Bocci G, Man S, Green SK, et al. Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies. Cancer Res 2004; 64(18): 6616.
18. Watanabe H, Mamelak AJ, Wang B, et al. Anti-vascular endothelial growth factor receptor-2 (Flk-1/KDR) antibody suppresses contact hypersensitivity. Exp Dermatol 2004; 13(11): 671.
19. Watanabe H, Mamelak AJ, Weiss E, et al. Anti-vascular endothelial growth factor receptor-2 antibody accelerates renal disease in the NZB/W F1 murine systemic lupus erythematosus model. Clin Cancer Res 2005; 11(1): 407.
20. Yoshiji H, Kuriyama S, Yoshii J, et al. Halting the interaction between vascular endothelial growth factor and its receptors attenuates liver carcinogenesis in mice. Hepatology 2004; 39(6): 1517.
21. Shibuya M. Structure and function of VEGF/VEGF-receptor system involved in angiogenesis. Cell Struct Funct 2001; 26(1): 25.
22. Klagsbrun M, D'Amore PA. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev 1996; 7(3): 259.
23. Barleon B, Sozzani S, Zhou D, et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 1996; 87(8): 3336.
24. Barleon B, Siemeister G, Martiny-Baron G, et al. Vascular endothelial growth factor up-regulates its receptor fms-like tyrosine kinase 1 (FLT-1) and a soluble variant of FLT-1 in human vascular endothelial cells. Cancer Res 1997; 57(23): 5421.
25. Zeng H, Sanyal S, Mukhopadhyay D. Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem 2001; 276(35): 32714.
26. Kim I, Moon SO, Kim SH, et al. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J Biol Chem 2001; 276(10): 7614.
27. Waltenberger J, Claesson-Welsh L, Siegbahn A, et al. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 1994; 269(43): 26988.
28. Clauss M, Weich H, Breier G, et al. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J Biol Chem 1996; 271(30): 17629.