Anosognosia for behavioral disturbances in frontotemporal dementia and corticobasal syndrome: A voxel-based morphometry study

Dementia and Geriatric Cognitive Disorders

Volumn 29, Issue 1, 2010, Pages 88-96

  Zamboni, G ^a,c   Grafman, J ^a   Krueger, F ^a   Knutson, K M ^a   Huey, E D ^a,b  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b Litwin Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders   (United States)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Anosognosia; Corticobasal syndrome; Frontal Systems Behavior Scale; Frontotemporal dementia; Loss of insight; Voxel based morphometry

Indexed keywords

ADULT; AGED; ANOSOGNOSIA; APHASIC VARIANT FRONTOTEMPORAL DEMENTIA; ARTICLE; BEHAVIOR DISORDER; BEHAVIORAL RESEARCH; BRAIN ATROPHY; CAREGIVER; CONTROLLED STUDY; CORTICOBASAL DEGENERATION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FRONTAL VARIANT FRONTOTEMPORAL DEMENTIA; FRONTOTEMPORAL DEMENTIA; GRAY MATTER; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE RECONSTRUCTION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PARIETAL LOBE; PRIORITY JOURNAL; RATING SCALE; SELF EVALUATION; SUBICULUM; TEMPORAL CORTEX;

AGED; ATROPHY; BASAL GANGLIA; BASAL GANGLIA DISEASES; BEHAVIOR; BEHAVIORAL SYMPTOMS; BRAIN; DISEASE PROGRESSION; FEMALE; FRONTAL LOBE; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PARIETAL LOBE; PSYCHIATRIC STATUS RATING SCALES; RETROSPECTIVE STUDIES; SOCIOECONOMIC FACTORS; TEMPORAL LOBE;

EID: 76149120432     PISSN: 14208008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000255141     Document Type: Article

References (42)

1. Mendez MF, Shapira JS: Loss of insight and functional neuroimaging in frontotemporal dementia. J Neuropsychiatry Clin Neurosci 2005; 17: 413-416.
2. O'Keeffe FM, Murray B, Coen RF, Dockree PM, Bellgrove MA, Garavan H, Lynch T, Robertson IH: Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy. Brain 2007; 130: 753-764.
3. Ruby P, Schmidt C, Hogge M, D'Argembeau A, Collette F, Salmon E: Social mind representation: where does it fail in frontotemporal dementia? J Cogn Neurosci 2007; 19: 671-683.
4. Salmon E, Perani D, Herholz K, Marique P, Kalbe E, Holthoff V, Delbeuck X, Beuthien- Baumann B, Pelati O, Lespagnard S, Collette F, Garraux G: Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease. Hum Brain Mapping 2006; 27: 588-597.
5. Derouesne C, Thibault S, Lagha-Pierucci S, Baudouin-Madec V, Ancri D, Lacomblez L: Decreased awareness of cognitive deficits in patients with mild dementia of the Alzheimer type. Int J Geriatr Psychiatry 1999; 14: 1019-1030.
6. Migliorelli R, Teson A, Sabe L, Petracca G, Petracchi M, Leiguarda R, Starkstein SE: Anosognosia in Alzheimer's disease: a study of associated factors. J Neuropsychiatry Clin Neurosci 1995; 7: 338-344.
7. Reed BR, Jagust WJ, Coulter L: Anosognosia in Alzheimer's disease: relationships to depression, cognitive function, and cerebral perfusion. J Clin Exp Neuropsychol 1993; 15: 231-244.
8. Vogel A, Hasselbalch SG, Gade A, Ziebell M, Waldemar G: Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease. Int J Geriatr Psychiatry 2005; 20: 238-246.
9. Starkstein SE, Jorge R, Mizrahi R, Robinson RG: A diagnostic formulation for anosognosia in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2006; 77: 719-725.
10. Rankin KP, Baldwin E, Pace-Savitsky C, Kramer JH, Miller BL: Self awareness and personality change in dementia. J Neurol Neurosurg Psychiatry 2005; 76: 632-639.
11. Salmon E, Perani D, Collette F, Feyers D, Kalbe E, Holthoff V, Sorbi S, Herholz K: A comparison of unawareness in frontotemporal dementia and Alzheimer's disease. J Neurol Neurosurg Psychiatry 2008; 79: 176-179.
12. Eslinger PJ, Dennis K, Moore P, Antani S, Hauck R, Grossman M: Metacognitive deficits in frontotemporal dementia. J Neurol Neurosurg Psychiatry 2005; 76: 1630-1635.
13. Orfei MD, Robinson RG, Prigatano GP, Starkstein S, Rusch N, Bria P, Caltagirone C, Spalletta G: Anosognosia for hemiplegia after stroke is a multifaceted phenomenon: a systematic review of the literature. Brain 2007; 130: 3075-3090.
14. Pia L, Neppi-Modona M, Ricci R, Berti A: The anatomy of anosognosia for hemiplegia: a meta-analysis. Cortex 2004; 40: 367-377.
15. Shibata K, Narumoto J, Kitabayashi Y, Ushijima Y, Fukui K: Correlation between anosognosia and regional cerebral blood flow in Alzheimer's disease. Neurosci Lett 2008; 435: 7-10.
16. Ott BR, Noto RB, Fogel BS: Apathy and loss of insight in Alzheimer's disease: a SPECT imaging study. J Neuropsychiatry Clin Neurosci 1996; 8: 41-46.
17. Lopez OL, Becker JT, Somsak D, Dew MA, DeKosky ST: Awareness of cognitive deficits and anosognosia in probable Alzheimer's disease. Eur Neurol 1994; 34: 277-282.
18. Kashiwa Y, Kitabayashi Y, Narumoto J, Nakamura K, Ueda H, Fukui K: Anosognosia in Alzheimer's disease: ASSOCIATION with patient characteristics, psychiatric symptoms and cognitive deficits. Psychiatry Clin Neurosci 2005; 59: 697-704.
19. Dalla Barba G, Parlato V, Iavarone A, Boller F: Anosognosia, intrusions and 'frontal' functions in Alzheimer's disease and depression. Neuropsychologia 1995; 33: 247-259.
20. Eslinger PJ, Damasio AR: Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR. Neurology 1985; 35: 1731-1741.
21. Decety J, Lamm C: The role of the right temporoparietal junction in social interaction: how low-level computational processes contribute to meta-cognition. Neuroscientist 2007; 13: 580-593.
22. Decety J, Sommerville JA: Shared representations between self and other: a social cognitive neuroscience view. Trends Cogn Sci 2003; 7: 527-533. (Pubitemid 37476246)
23. Ruby P, Decety J: How would you feel versus how do you think she would feel? A neuroimaging study of perspective-taking with social emotions. J Cogn Neurosci 2004; 16: 988-999.
24. Blakemore SJ, Frith C: Self-awareness and action. Curr Opin Neurobiol 2003; 13: 219-224.
25. Grace J, Malloy P: Frontal Systems Behavior Scale (FrSBe): Professional Manual. Lutz, Psychological Assessment Resources, 2001.
26. Zamboni G, Huey ED, Krueger F, Nichelli PF, Grafman J: Apathy and disinhibition in frontotemporal dementia: insights into their neural correlates. Neurology 2008; 71: 736-742.
27. Rosen HJ, Allison SC, Schauer GF, Gorno- Tempini ML, Weiner MW, Miller BL: Neuroanatomical correlates of behavioural disorders in dementia. Brain 2005; 128: 2612-2625.
28. McKhann GM, Albert MS, Grossman M, Miller B, Dickson D, Trojanowski JQ: Clinical and pathological diagnosis of frontotemporal dementia: report of the work group on frontotemporal dementia and Pick's disease. Arch Neurol 2001; 58: 1803-1809.
29. Boeve BF, Lang AE, Litvan I: Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia. Ann Neurol 2003; 54(suppl 5): S15-S19.
30. Mattis S: Dementia Rating Scale: Professional Manual. Odessa, Psychological Assessment Resources, 1988.
31. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J: An inventory for measuring depression. Arch General Psychiatry 1961; 4: 561-571.
32. Wechsler D: Wechsler Memory Scale, ed 3 (WMS-III). San Antonio, Psychological Corporation, 1997.
33. Delis DC, Kaplan E, Kramer JH: The Delis- Kaplan Executive Function System: Examiner's Manual. San Antonio, Psychological Corporation, 2001.
34. De Renzi E, Vignolo LA: The token test: a sensitive test to detect receptive disturbances in aphasics. Brain 1962; 85: 665-678.
35. Kaplan EF, Goodglass H, Weintraub S: The Boston Naming Test. Philadelphia, Lea & Febiger, 1983.
36. Ashburner J: A fast diffeomorphic image registration algorithm. Neuroimage 2007; 38: 95-113.
37. Ridgway GR, Henley SM, Rohrer JD, Scahill RI, Warren JD, Fox NC: Ten simple rules for reporting voxel-based morphometry studies. Neuroimage 2008; 40: 1429-1435.
38. Rorden C, Brett M: Stereotaxic display of brain lesions. Behav Neurol 2000; 12: 191-200.
39. Ruby P, Collette F, D'Argembeau A, Peters F, Degueldre C, Balteau E, Luxen A, Maquet P, Salmon E: Perspective taking to assess selfpersonality: what's modified in Alzheimer's disease? Neurobiol Aging 2009; 30: 1637-1651.
40. Heilman KM, Barrett AM, Adair JC: Possible mechanisms of anosognosia: a defect in self-awareness. Philos Trans R Soc Lond B Biol Sci 1998; 353: 1903-1909.
41. Decety J, Moriguchi Y: The empathic brain and its dysfunction in psychiatric populations: implications for intervention across different clinical conditions. Biopsychosoc Med 2007; 1: 22.
42. Boddaert N, Chabane N, Gervais H, Good CD, Bourgeois M, Plumet MH, Barthelemy C, Mouren MC, Artiges E, Samson Y, Brunelle F, Frackowiak RS, Zilbovicius M: Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study. Neuroimage 2004; 23: 364-369.