Successful treatment of severe hypertriglyceridemia with a formula diet rich in omega-3 fatty acids and medium-chain triglycerides

Annals of Nutrition and Metabolism

Volumn 56, Issue 3, 2010, Pages 170-175

  Hauenschild, Annette ^a   Bretzel, Reinhard G ^a   Schnell Kretschmer, Henning ^a   Kloer, Hans Ulrich ^a   Hardt, Philip D ^a   Ewald, Nils ^a  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

Author keywords

Fatty acid 3; Hypertriglyceridemia; Medium chain; Triglyceride

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER; CHYLOMICRON; GLUCOSE; LOW DENSITY LIPOPROTEIN; MEDIUM CHAIN TRIACYLGLYCEROL; OMEGA 3 FATTY ACID; PHOSPHOLIPID; TRIACYLGLYCEROL; URIC ACID; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; DIET; DIET THERAPY; DIETARY INTAKE; DISEASE SEVERITY; FEMALE; FORMULA DIET; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTRIGLYCERIDEMIA; MAJOR CLINICAL STUDY; MALE; PATIENT SAFETY; PRIORITY JOURNAL; TREATMENT DURATION; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; BLOOD GLUCOSE; BODY MASS INDEX; DIET; DIETARY CARBOHYDRATES; DIETARY FATS; DIETARY PROTEINS; FATTY ACIDS, OMEGA-3; FEMALE; HUMANS; HYPERTRIGLYCERIDEMIA; LIPIDS; MALE; MIDDLE AGED; PHOSPHOLIPIDS; TRIGLYCERIDES; URIC ACID; YOUNG ADULT;

EID: 76149103918     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000283561     Document Type: Article

References (21)

1. Schaefer EJ, McNamara JR, Genest J Jr, Ordovas JM: Clinical significance of hypertriglyceridemia. Semin Thromb Hemost 1988; 14: 143-148.
2. Deng LH, Xue P, Xia Q, Yang XN, Wan MH: Effect of admission hypertriglyceridemia on the episodes of severe acute pancreatitis. World J Gastroenterol 2008; 14: 4558-4561.
3. Albrink MJ, Man EB: Serum triglycerides in coronary artery disease. Arch Intern Med 1959; 103: 4-8.
4. Dunn FL, Grundy SM, Bilheimer DW, Havel RJ, Raskin P: Impaired catabolism of very low-density lipoprotein-triglycerides in a family with primary hypertriglyceridemia. Metabolism 1985; 34: 316-324.
5. West KM, Ahuja MM, Bennett PH, et al: The role of circulating glucose and triglyceride concentrations and their interactions with other 'risk factors' as determinations of arterial disease in nine diabetic population samples from the WHO multinational study. Diabetes Care 1983; 6: 361-369.
6. Fontbonne A, Eschwege E, Cambien F, Richard JL, Ducimetière P, Thibult N, Warnet JM, Claude JR, Rosselin GE: Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Results from the 11-year follow-up of the Paris Prospective Study. Diabetologia 1989; 32: 300-304. (Pubitemid 19166483)
7. Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, Boekholdt SM, Khaw KT, Gudnason V: Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation 2007; 115: 450-458. (Pubitemid 46184196)
8. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg- Hansen A: Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007; 298: 299-308. (Pubitemid 47080484)
9. Leaf DA, Connor WE, Illingworth R, Bacon SP, Sexton G: The hypolipidemic effects of gemfibrozil in type V hyperlipidemia. A double-blind crossover study. JAMA 1989; 262: 3154-3160. (Pubitemid 20002634)
10. Oh RC, Lanier JB: Management of hypertriglyceridemia. Am Fam Physician 2007; 75: 1365-1371.
11. Bach AC, Babayan VK: Medium-chain triglycerides: an update. Am J Clin Nutr 1982; 36: 950-962.
12. Phillipson BE, Rothrock DW, Connor WE, Harris WS, Illingworth DR: Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. N Engl J Med 1985; 312: 1210-1216.
13. Harris WS: N-3 fatty acids and serum lipoproteins: human studies. Am J Clin Nutr 1997; 65(suppl):1645S-1654S. (Pubitemid 27187958)
14. Leaf DA: Chylomicronemia and the chylomicronemia syndrome: a practical approach to management. Am J Med 2008; 121: 10-12.
15. McKenney JM, Sica D: Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. Pharmacotherapy 2007; 27: 715-728. (Pubitemid 46700964)
16. Aliget VR, Gandhi M, Braden R, Rezk A, Elam MB: Effect of combination lipid-modifying therapy on the triglyceride lowering effect of fish oil. Am J Med Sci 2007; 333: 168-172. (Pubitemid 47181616)
17. Bays H: Rationale for prescription omega-3- acid ethyl ester therapy for hypertriglyceridemia: a primer for clinicians. Drugs Today (Barc) 2008; 44: 205-246. (Pubitemid 351669107)
18. Singer P, Wirth M, Berger I, Voigt S, Gerike U, Gödicke W, Köberle U, Heine H: Influence on serum lipids, lipoproteins and blood pressure of mackerel and herring diet in patients with type IV and V hypertriglyceridemia. Atherosclerosis 1985; 56: 111-118. (Pubitemid 15049653)
19. Mackness MI, Bhatnagar D, Durrington PN, Prais H, Haynes B, Morgan J, Borthwick L: Effects of a new fish oil concentrate on plasma lipids and lipoproteins in patients with hypertriglyceridemia. Eur J Clin Nutr 1994; 48: 859-865.
20. Herold PM, Kinsella JE: Fish oil consumption and decreased risk of cardiovascular disease: a comparison of findings from animal and human feeding trials. Am J Clin Nutr 1986; 43: 566-598.
21. Abbey M, Clifton P, Kestin M, Beiling B, Nestel P: Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans. Arteriosclerosis 1990; 10: 85-94. (Pubitemid 20035107)