Effect of combination lipid-modifying therapy on the triglyceride lowering effect of fish oil

American Journal of the Medical Sciences

Volumn 333, Issue 3, 2007, Pages 168-172

  Aligeti, Venkata R ^a   Gandhi, Malay ^a   Braden, Ron ^a   Rezk, Amira ^a   Elam, Marshall B ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Fish oil; Lipoproteins; PPAR ; Triglyceride

Indexed keywords

ATORVASTATIN; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FISH OIL; FLUINDOSTATIN; GEMFIBROZIL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEVINOLIN; NICOTINIC ACID; SIMVASTATIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DATA BASE; DIABETES MELLITUS; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; HUMAN; HYPERTRIGLYCERIDEMIA; ISCHEMIC HEART DISEASE; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; MONOTHERAPY; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL;

ANALYSIS OF VARIANCE; ANTILIPEMIC AGENTS; DRUG THERAPY, COMBINATION; FISH OILS; HUMANS; HYPERTRIGLYCERIDEMIA; LIPOPROTEINS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 34547550140     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e3180312ebf     Document Type: Article

References (13)

1. Marchioli R, Barzi F, Bomba E, et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002;105:1874-5.
2. Holub DJ, Holub BJ. Omega-3 fatty acids from fish oils and cardiovascular disease. Mol Cell Biochem 2004;263:217-25.
3. Illingworth DR, Connor WE, Hatcher LF, et al. Hypolipidemic effects of n-3 fatty acids in primary hyperlipoproteinaemia. J Intern Med Suppl 1989;731:91-7.
4. Tato F, Keller C, Wolfram G. Effects of fish oil concentrate on lipoproteins and apolipoproteins in familial combined hyperlipidemia. Clin Investig 1993;71:314-8.
5. Fasching P, Rohac M, Liener K, et al. Fish oil supplementation versus gemfibrozil treatment in hyperlipidemic NIDDM. A randomized crossover study. Horm Metab Res 1996;28:230-6.
6. Staels B, Dallongeville J, Auwerx J. Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 1998;98:2088-93.
7. Davidson MH, Macariola-Coad JR, McDonald AM, et al. Separate and joint effects of marine oil and simvastatin in patients with combined hyperlipidemia. Am J Cardiol 1997;80:797-8.
8. Thomas J, Bramlett KS, Montrose C, et al. A chemical switch regulates fibrate specificity for peroxisome-proliferator-activated receptor (PPAR) vs. liver X receptor (LXR). J Biol Chem 2003;2403.
9. Jump DB, Macariola-Coad A, Thelen Ren B, et al. Multiple mechanisms for polyunsaturated fatty acid regulation of hepatic gene transcription. Prostaglandins Leukot Essent Fatty Acids 1999;60:345-9.
10. Dallongeville J, Bauge E, Tailleux A, et al. Peroxisome proliferator-activated receptor alpha is not rate-limiting for the lipoprotein-lowering action of fish oil. J Biol Chem 2001;276:4634-9.
11. Xu J, Nakamura MT, Cho HP, et al. SREBP-1c expression is suppressed by dietary polyunsaturated fatty acids. J of Biol Chem 1999;274:23577-83.
12. Deng X, Elam MB, Wilcox HG, et al. Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression. Endocrinology 2004;145:5847-61.
13. Harris WS, Ginsberg HN, Arunakul N, et al. Safety and efficacy of Omacor in severe hypertriglyceridemia. J Cardiovasc Risk 1997;4:385-91.