Proton secretion in freshly excised sinonasal mucosa from asthma and sinusitis patients

American Journal of Rhinology and Allergy

Volumn 23, Issue 6, 2009, Pages

  Cho, Do Yeon ^a,b   Hajighasemi, Mohammad ^b   Hwang, Peter H ^a   Illek, Beate ^b   Fischer, Horst ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Acidic; Airway surface liquid (ASL); Asthma; Mucosa; pH stat; Proton secretion; Sinusitis; Ussing chamber

Indexed keywords

ZINC CHLORIDE;

ACID SECRETION; ARTICLE; ASTHMA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NOSE MUCOSA; PH MEASUREMENT; PROTON TRANSPORT; RHINOSINUSITIS; TITRIMETRY;

ASTHMA; CELLS, CULTURED; CHLORIDES; CHRONIC DISEASE; EOSINOPHILIA; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNITY, INNATE; ION CHANNELS; ION TRANSPORT; NASAL MUCOSA; NASAL POLYPS; ORGAN CULTURE TECHNIQUES; PARANASAL SINUSES; PROTONS; RHINITIS; SINUSITIS; ZINC COMPOUNDS;

EID: 76149095181     PISSN: 19458924     EISSN: 19458932     Source Type: Journal    
DOI: 10.2500/ajra.2009.23.3389     Document Type: Article

References (21)

1. Knowles MR, and Boucher RC. Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest 109:571-577, 2002.
2. Fischer H, Widdicombe JH, and Illek B. Acid secretion and proton conductance in human airway epithelium. Am J Physiol Cell Physiol 282:C736-C743, 2002.
3. Widdicombe JH. Volume of airway surface liquid in health and disease. Am J Respir Crit Care Med 165:1566, 2002.
4. Bodem CR, Lampton LM, Miller DP, et al. Endobronchial pH. Relevance of aminoglycoside activity in gram-negative bacillary pneumonia. Am Rev Respir Dis 127:39-41, 1983.
5. Jayaraman S, Song Y, and Verkman AS. Airway surface liquid pH in well-differentiated airway epithelial cell cultures and mouse trachea. Am J Physiol Cell Physiol 281:C1504-C1511, 2001.
6. Kostikas K, Papatheodorou G, Ganas K, et al. pH in expired breath condensate of patients with inflammatory airway diseases. Am J Respir Crit Care Med 165:1364-1370, 2002.
7. Ng AW, Bidani A, and Heming TA. Innate host defense of the lung: Effects of lung-lining fluid pH. Lung 182:297-317, 2004.
8. Dixon AE. Rhinosinusitis and asthma: The missing link. Curr Opin Pulm Med 15:19-24, 2009.
9. Hunt JF, Fang K, Malik R, et al. Endogenous airway acidification. Implications for asthma pathophysiology. Am J Respir Crit Care Med 161:694-699, 2000.
10. Ricciardolo FLM, Gaston B, and Hunt J. Acid stress in the pathology of asthma. J Allergy Clin Immunol 113:610-619, 2004.
11. Benninger MS, Ferguson BJ, Hadley JA, et al. Adult chronic rhinosinusitis: Definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngol Head Neck Surg 129(suppl):S1-S32, 2003.
12. Guidelines for the evaluation of impairment/disability in patients with asthma. American Thoracic Society. Medical Section of the American Lung Association. Am Rev Respir Dis 147:1056-1061, 1993.
13. Guba M, Kuhn M, Forssmann WG, et al. Guanylin strongly stimulates rat duodenal. Gastroenterology 111:1558-1568, 1996.
14. Smith TL, Mendolia-Loffredo S, Loehrl TA, et al. Predictive factors and outcomes in endoscopic sinus surgery for chronic rhinosinusitis. Laryngoscope 115:2199-2205, 2005.
15. Kodric M, Shah AN, Fabbri LM, and Confalonieri M. An investigation of airway acidification in asthma using induced sputum: A study of feasibility and correlation. Am J Respir Crit Care Med 175:905-910, 2007.
16. Paget-Brown AO, Ngamtrakulpanit L, Smith A, et al. Normative data for pH of exhaled breath condensate. Chest 129:426-430, 2006.
17. Coakley RD, Grubb BR, Paradiso AM, et al. Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium. Proc Natl Acad Sci USA 100:16083-16088, 2003.
18. Inglis SK, Wilson SM, and Olver RE. Secretion of acid and base equivalents by intact distal airways. Am J Physiol Lung Cell Mol Physiol 284:L855-L862, 2003.
19. Fischer H. Airway surface liquid pH and innate defense by the NADPH oxidase. Pediatr Pulmonol 42:175-177, 2007.
20. Schwarzer C, Machen TE, Illek B, and Fischer H. NADPH oxidase-dependent acid production in airway epithelial cells. J Biol Chem 279:36454-36461, 2004.
21. Harper RW, Xu C, Eiserich JP, et al. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett 579:4911-4917, 2005.