Porphyromonas gingivalis infection-induced tissue and bone transcriptional profiles

Molecular Oral Microbiology

Volumn 25, Issue 1, 2010, Pages 61-74

  Meka, A ^a,f   Bakthavatchalu, V ^b   Sathishkumar, S ^b,g   Lopez, M C ^c   Verma, R K ^a   Wallet, S M ^a,d   Bhattacharyya, I ^d   Boyce, B F ^e   Handfield, M ^d   Lamont, R J ^d   Baker, H V ^c   Ebersole, J L ^b   Kesavalu, L ^a,d  

^a UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF FLORIDA   (United States)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^f NONE   (United States)

^g Genetic ID NA Inc   (United States)

Author keywords

Bone; Calvarial tissue; Gene expression; Microarray; Porphyromonas gingivalis

Indexed keywords

B LYMPHOCYTE RECEPTOR; CELL ADHESION MOLECULE; IMMUNOGLOBULIN G ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TOLL LIKE RECEPTOR; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CALVARIA; CHEMOTAXIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; LYMPHOCYTE ACTIVATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OSTEITIS; OSTEOCLAST; OSTEOLYSIS; PORPHYROMONAS GINGIVALIS; RNA ISOLATION; RNA TRANSCRIPTION; SOFT TISSUE;

ANIMALS; BACTEROIDACEAE INFECTIONS; BONE AND BONES; BONE RESORPTION; CELL ADHESION MOLECULES; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; HOST-PATHOGEN INTERACTIONS; INFLAMMATION; INFLAMMATION MEDIATORS; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOCLASTS; PORPHYROMONAS GINGIVALIS; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC;

EID: 76149084802     PISSN: 20411006     EISSN: 20411014     Source Type: Journal    
DOI: 10.1111/j.2041-1014.2009.00555.x     Document Type: Article

References (42)

1. Baker, P.J., DuFour, L., Dixon, M. Roopenian, D.C. (2000) Adhesion molecule deficiencies increase Porphyromonas gingivalis-induced alveolar bone loss in mice. Infect Immun 68 : 3103 3107. (Pubitemid 30340396)
2. Boyce, B.F., Aufdemorte, T.B., Garrett, I.R., Yates, A.J.P. Mundy, G.R. (1989) Effects of interleukin-1 on bone turnover in normal mice. Endocrinology 125 : 1142 1150.
3. Chang, H., Brown, C.W. Matzuk, M.M. (2002) Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev 23 : 787 823.
4. Chou, H.H., Yumoto, H., Davey, M. et al. (2005) Porphyromonas gingivalis fimbria-dependent activation of inflammatory genes in human aortic endothelial cells. Infect Immun 73 : 5367 5378.
5. Collazo, C.M., Yap, G.S., Hieny, H. et al. (2002) The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. Infect Immun 70 : 6933 6939.
6. Costalonga, M., Batas, L. Reich, B.J. (2009) Effects of Toll-like receptor 4 on Porphyromonas gingivalis-induced bone loss in mice. J Periodontal Res 44 : 537 542.
7. Demmer, R.T., Behle, J.H., Wolf, D.L. et al. (2008) Transcriptomes in healthy and diseased gingival tissues. J Periodontol 79 : 2112 2124.
8. Dennis, G. Jr., Sherman, B.T., Hosack, D.A. et al. (2003) DAVID: database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4 : P3.
9. Draghici, S., Khatri, P., Eklund, A.C. Szallasi, Z. (2006) Reliability and reproducibility issues in DNA microarray measurements. Trends Genet 22 : 101 109.
10. Eisen, M.B., Spellman, P.T., Brown, P.O. Botstein, D. (1998) 1998. Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95 : 14863 14868.
11. Feezor, R.J., Oberholzer, C., Baker, H.V. et al. (2003) Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun 71 : 5803 5813.
12. Gemmell, E., Winning, T.A., Bird, P.S. Seymour, G.J. (1998) Cytokine profiles of lesional and splenic T cells in Porphyromonas gingivalis infection in a murine model. J Periodontol 69 : 1131 1138.
13. Gemmell, E., Drysdale, K.E. Seymour, G.J. (2006) Gene expression in splenic CD4 and CD8 cells from BALB/c mice immunized with Porphyromonas gingivalis. J Periodontol 77 : 622 633.
14. Han, X. Amar, S. (2002) Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis. J Dent Res 81 : 399 405.
15. Handfield, M., Mans, J.J., Zheng, G. et al. (2005) Distinct transcriptional profiles characterize oral epithelium-microbiota interactions. Cell Microbiol 7 : 811 823.
16. Handfield, M., Baker, H.V. Lamont, R.J. (2008) Beyond good and evil in the oral cavity: insights into host-microbe relationships derived from transcriptional profiling of gingival cells. J Dent Res 87 : 203 223.
17. Hasigawa, Y., Tribble, G.D., Baker, H.V., Mans, J.J., Handfield, M. Lamont, R.J. (2008) Role of Porphyromonas gingivalis SerB in gingival epithelial cell cytoskeletal remodeling and cytokine production. Infect Immun 76 : 2420 2427.
18. Holt, S.C., Kesavalu, L., Walker, S. Genco, C.A. (1999) Virulence factors of Porphyromonas gingivalis. Periodontol 2000 20 : 168 238.
19. Hosack, D.A., Dennis, G. Jr., Sherman, B.T., Lane, H.C. Lempicki, R.A. (2003) Identifying biological themes within lists of genes with EASE. Genome Biol 4 : R70.
20. Kasamatsu, A., Uzawa, K., Shimada, K. et al. (2005) Elevation of galectin-9 as an inflammatory response in the periodontal ligament cells exposed to Porphyromonas gingivalis lipopolysaccharide in vitro and in vivo. Int J Biochem Cell Biol 37 : 397 408.
21. Kesavalu, L., Ebersole, J.L., Machen, R.L. Holt, S.C. (1992) Porphyromonas gingivalis virulence in mice: induction of immunity to bacterial components. Infect Immun 60 : 1455 1464.
22. Kesavalu, L., Chandrasekar, B. Ebersole, J.L. (2002) In vivo induction of proinflammatory cytokines in mouse tissue by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans. Oral Microbiol Immunol 17 : 177 180.
23. Khatri, P. Draghici, S. (2005) Ontological analysis of gene expression data: current tools, limitations, and open problems. Bioinformatics 21 : 3857 3895.
24. Kinane, D.F., Podmore, M., Murray, M.C., Hodge, P.J. Ebersole, J.L. (2001) Etiopathogenesis of periodontitis in children and adolescents. Periodontol 2000 26 : 54 91.
25. Lamont, R.J. Jenkinson, H.F. (1998) Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 62 : 1244 1263.
26. Ley, K. Kansas, G.S. (2004) Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation. Nat Rev Immunol 4 : 325 335.
27. Li, B. (2008) Bone morphogenetic protein-Smad pathway as drug targets for osteoporosis and cancer therapy. Endocr Metab Immune Disord Drug Targets 8 : 208 219.
28. Li, C. Wong, W.H. (2001) Model-based analysis of oligonucleotide arrays: expression index computation and outlier detection. Proc Natl Acad Sci USA 98 : 31 36.
29. Lian, J.B., Stein, G.S., Javed, A. et al. (2006) Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord 7 : 1 16.
30. Niederman, R., Westernoff, T., Lee, C. et al. (2001) Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. J Clin Periodontol 28 : 569 575.
31. Ohno, T., Okahashi, N., Kawai, S. et al. (2006) Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis. Microbes Infect 8 : 1025 1034.
32. Orozco, A., Gemmell, E., Bickel, M. Seymour, G.J. (2007) Interleukin 18 and periodontal disease. J Dent Res 86 : 586 593.
33. Oshikawa, M., Sugano, N., Koshi, R., Ikeda, K. Ito, K. (2004) Differential gene induction in macrophage-like human cells by two types of Porphyromonas gingivalis: a microarray study. J Oral Sci 46 : 9 14.
34. Piana, C., Wirth, M., Gerbes, S., Viernstein, H., Gabor, F. Toegel, S. (2008) Validation of reference genes for qPCR studies on caco-2 cell differentiation. Eur J Pharm Biopharm 69 : 1187 1192.
35. Sasaki, H., Okamatsu, Y., Kawai, T., Kent, R., Taubman, M. Stashenko, P. (2004) The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res 39 : 432 441.
36. Smith, A., Stanley, P., Jones, K., Svensson, L., McDowall, A. Hogg, N. (2007) The role of the integrin LFA-1 in T-lymphocyte migration. Immunol Rev 218 : 135 146.
37. Tatakis, D.N. Kumar, P.S. (2005) Etiology and pathogenesis of periodontal diseases. Dent Clin North Am 49 : 491 516.
38. Tsuchida, K., Nakatani, M., Uezumi, A., Murakami, T. Cui, X. (2008) Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer. Endocr J 55 : 11 21.
39. Wada, T., Nakashima, T., Hiroshi, N. Penninger, J.M. (2006) RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med 12 : 17 25.
40. Wang, P.L., Ohura, K., Fujii, T. et al. (2003) DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues. Biochem Biophys Res Commun 305 : 970 973.
41. Zhou, Q. Amar, S. (2006) 2006. Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infect Immun 74 : 1204 1214.
42. Zubery, Y., Dunstan, C.R., Story, B.M. et al. (1998) Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin. Infect Immun 66 : 4158 4162.