Development and evaluation of nefopam transdermal matrix patch system in human volunteers

PDA Journal of Pharmaceutical Science and Technology

Volumn 63, Issue 6, 2009, Pages 537-546

  De, Pintu ^a   Damodharan, N ^b   Mallick, Subrata ^b   Mukherjee, Biswajit ^b  

^a Dr B C Roy College of Pharmacy and Allied Health Sciences   (India)

^b JADAVPUR UNIVERSITY   (India)

Author keywords

Controlled release; Formulation; FTIR; HPLC; In vitro and in vivo skin permeation studies; Nefopam; Scanning electron microscopy; Transdermal drug delivery

Indexed keywords

ETHYL CELLULOSE; NEFOPAM; POVIDONE;

ADULT; ARTICLE; CADAVER; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG HYPERSENSITIVITY; DRUG PACKAGING; DRUG SCREENING; EXCIPIENT COMPATIBILITY; HUMAN; HUMAN EXPERIMENT; INFRARED SPECTROSCOPY; MALE; NORMAL HUMAN; PATIENT COMPLIANCE; PHYSICAL CHEMISTRY; PRURITUS; RASH; SKIN IRRITATION; SKIN PERMEABILITY; SKIN REDNESS; SKIN SWELLING; SUSTAINED RELEASE PREPARATION; TOXICITY TESTING; TRANSDERMAL PATCH;

ADMINISTRATION, CUTANEOUS; ADULT; ANALGESICS, NON-NARCOTIC; BIOLOGICAL AVAILABILITY; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; EXCIPIENTS; HUMANS; MALE; MICROSCOPY, ELECTRON, SCANNING; NEFOPAM; PERMEABILITY; POVIDONE; SKIN ABSORPTION; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; YOUNG ADULT;

EID: 76049121054     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Mukherjee, B.; Mahapatra, S.; Gupta, R.; Patra, B.; Tiwari, A.; Arora, P. A comparison between povidone-ethylcellulose and providone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation. Eur. J. Pharm. Biopharm. 2005, 59 (3), 475-483.
2. Misra, A. N. Transdermal Drug Delivery. In Controlled and Novel Drug Delivery; Jain, N. K., Ed.; Varghese Publication: New Delhi, 1988; pp 100-129.
3. Mukherjee, B.; Das, S.; Patra, B.; Layek, B. Nefopam containing transdermal-matrix patches based on pressure-sensitive adhesive polymers. Pharmaceutical Technology (USA) 2006, 30 (3), 146-163.
4. Aymard, G.; Warot, D.; Demolis, P.; Giudicelli, J. F.; Lechat, P.; Le Guern, M. E.; Alquier, C.; Diquet, B. Comparative pharmacokinetics and pharmacodynamics of intravenous and oral nefopam in healthy volunteers. Pharmacol. Toxicol. 2003, 92 (6), 279-286.
5. Fuller, R. W.; Snoddy, H. D. Evaluation of nefopam as a monoamine uptake inhibitor in vivo in mice. Neuropharmacology 1993, 32 (10), 995-999.
6. Heel, R. C. Nefopam: A review of its pharmacological properties and therapeutic efficacy. Drugs 1980, 19 (4), 249-267.
7. Arora, P.; Mukherjee, B. Design, development, physiochemical, and in vitro evaluation of transdemal patches containing diclofenac diethylammonium salt. J. Pharm. Sci. 2002, 91 (9), 2076-2089.
8. Mutalik, S.; Udupa, N. Glibenclamide transdermal patches patches: Physicochemical, pharmacodynamic and pharmacokinetic evaluations. J. Pharm. Sci. 2004, 93 (6), 1577-1594.
9. Thomas, N. S.; Panchagula, R. Transdermal delivery of zidovudine: Effect of vehicles on permeation across rat skin and their mechanism of action. Eur. J. Pharm. Sci. 2003, 18 (1), 71-79.
10. Pequignot, A.; Tumosa, C. S.; von Endt, D. W. The effect of tanning and fixing processes of the properties of taxidermy skins. Collection Forum 2006, 21 (1-2), 133-142.
11. Hood, B. L.; Conrads, T. P.; Veenstra, T. D. Unravelling the proteome of formalin-fixed paraffin-embedded tissue. Briefings in Functional Genomics Proteomics 2006, 5 (2), 169-175.
12. www.scienceinthebox.com/en-UK/safety/skinirritation-en.html. Accessed, on March 27, 2003.
13. Aymard, G.; Warot, D.; Demolis, P.; Laville, I.; Diquet, B. Sensitive determination of nefopam and its metabolite desmethyl-nefopam in human biological fluid by HPLC. J. Pharm. Biomed. Anal. 2002, 30 (4), 1013-1021.
14. Chang, L.; Wang, D. Rapid fluorimetric assay for plasma nefopam using high-performance liquid chromatography. J. Liq. Chromatogr. 1994, 17 (9), 1971-1980.
15. Katayose, S.; Kataoka, K. Water soluble polyion complex associates of DNA and poly (ethylene glycol)-poly (L-Lysin) block copolymers. Bioconjugate Chem. 1997, 8 (5), 702-707.
16. Anderson, D. T.; Muto, J. J. Duragesic transdermal patch: Postmortem tissue distribution of fentanyl in 25 cases. J. Anal. Toxicol. 2000, 24 (7), 627-34.
17. Bodmeier, R.; Paeratakul, O. Drug release from laminated polymeric films prepared from aqueous latexes. J. Pharm. Sci. 1990, 79 (10), 32-36.
18. Fan, L. T.; Singh, S. K. Controlled Release: A Quantitative Treatment. Spinger-Verlag: New York, 1989; pp 13-129.
19. Kotting, C; Gerwert, K. Monitoring protein ligand interactions by time resolved FTIR difference spectroscopy. Methods Mol. Biol. 2005, 305, 261-286.
20. Chien, Y. W. Transdermal Therapeutic System In; Controlled Drug Delivery: Fundamentals and Applications. Robinson, J. R., Lee, V. H. L., Eds.; Marcel Dekker: New York, 1987; pp 524-552.
21. Johnson, M. E.; Blankschtein, D.; Langer, R. Evaluation of solute permeation through the stratum corneum: Lateral bilayer diffusion as the primary transport mechanism. J. Pharm. Sci. 1997, 86 (10), 1162-1172.
22. Martin, A.; Bustamante, P.; Chun, A. H. C. Physical Pharmacy; B. I. Waverly Private Limited: New Delhi, India, 1999; pp 284-323.
23. www.tiaft.org (as reported by the International Association of Forensic Toxicologists in its web site mentioned here). Accessed November 12, 2004.