Sensitive determination of nefopam and its metabolite desmethyl-nefopam in human biological fluids by HPLC

Journal of Pharmaceutical and Biomedical Analysis

Volumn 30, Issue 4, 2002, Pages 1013-1021

  Aymard, G ^a   Warot, D ^a   Demolis, P ^a   Laville, I ^a   Diquet, B ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

Desmethyl nefopam; High performance liquid chromatography; Nefopam

Indexed keywords

DRUG METABOLITE; NEFOPAM; NORNEFOPAM; UNCLASSIFIED DRUG;

ACCURACY; ADULT; ARTICLE; CALIBRATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; HUMAN EXPERIMENT; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; VALIDATION PROCESS;

ADULT; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HUMANS; MALE; NEFOPAM;

EID: 0037038383     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(02)00443-0     Document Type: Article

References (7)

1. Heel R.C., Brogden R.N., Pakes G.E., Speight T.M., Avery G.S. Drugs. 19:1980;249-267.
2. Ehrsson H., Eksborg S. J. Chromatogr. 136:1977;154-158.
3. Schuppan D., Hansen C.S., Ober R.E. J. Pharm. Sci. 67:1978;1720-1723.
4. Chang S.F., Hansen C.S., Fox J.M., Ober R.E. J. Chromatogr. 226:1981;79-89.
5. Liu D.T.Y., Savage J.M., Donnell D. Br. J. Clin. Pharmacol. 23:1987;99-101.
6. Mather G.G., Labroo R., Le Guern M.E., Lepage F., Gillardin J.M., Levy R.H. Chirality. 12:2000;153-159.
7. Burton L.C., Loftus N.J., Vere D.W., Whelpton R. J. Chromatogr. 526:1990;159-168.