Coupled systolic-ventricular and vascular stiffening with age: Implications for pressure regulation and cardiac reserve in the elderly

Journal of the American College of Cardiology

Volumn 32, Issue 5, 1998, Pages 1221-1227

  Chen, Chen Huan ^a   Nakayama, Masaru ^c   Nevo, Erez ^a,b   Fetics, Barry J ^b   Lowell Maughan, W ^a,b   Kass, David A ^a,d  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b DEPARTMENT OF PATHOLOGY   (United States)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE HOSPITAL   (Japan)

^d JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL COMPLIANCE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART PRELOAD; HEART RATE; HEART VENTRICLE COMPLIANCE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RIGIDITY; SYSTOLIC BLOOD PRESSURE; SYSTOLIC HYPERTENSION;

ADULT; AGED; AGED, 80 AND OVER; AGING; BLOOD PRESSURE; BLOOD VESSELS; ELASTICITY; FEMALE; HEART CATHETERIZATION; HUMANS; MALE; MIDDLE AGED; STROKE VOLUME; SYSTOLE; VASCULAR RESISTANCE; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 0032211093     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(98)00374-X     Document Type: Article

References (43)

1. Avolio AP, Chen SG, Wang RP, Zhang CL, Li MF, O'Rourke MF. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 1983;68:50-8.
2. Nichols WW, O'Rourke MF, Avolio AP, et al. Effects of age on ventricular-vascular coupling. Am J Cardiol 1985;55:1179-84.
3. Kelly RP, Hayward C, Avolio AP, O'Rourke MF. Noninvasive determination of age-related changes in the human arterial pulse. Circulation 1989; 80:1652-9.
4. O'Rourke MF. Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension. Hypertension 1990;15:339-47.
5. Safar ME. Pulse pressure in essential hypertension: clinical and therapeutical implications. Hypertension 1989;7:769-76.
6. Franklin SS, Gustin W, Wong ND, et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 1997;96:308-15.
7. James MA, Watt PAC, Potter JF, Thurston H, Swales JD. Pulse pressure and resistance artery structure. Hypertension 1995;26:301-6.
8. Franklin SS, Weber MA Measuring hypertensive cardiovascular risk: the vascular overload concept. Am Heart J 1994;128:793-803.
9. Benetos A, Safar M, Rudnichi A, et al. Pulse pressure: a predictor of long-term cardiovascular mortality in a French male population. Hypertension 1997;30:1410-5.
10. Maggioni AP, Maseri A, Fresco C, et al. Age-related increase in mortality among patients with first myocardial infarctions treated with thrombolysis. N Engl J Med 1993;329:1442-8.
11. Loh E, Sutton MS, Wun CC, et al. Ventricular dysfunction and the risk of stroke after myocardial infarction. N Engl J Med 1997;336:251-7.
12. Pfeffer MA, Braunwald E, Moye LA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the Survival and Ventricular Enlargement Trial. N Engl J Med 1992;327:669-77.
13. Mitchell GF, Myoe LA, Braunwald E, et al. for the SAVE Investigators. Sphygomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. Circulation 1997;96:4254-60.
14. Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res 1991;68:1560-8.
15. Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 1993;73:413-67.
16. Starling MR. Left ventricular-arterial coupling relations in the normal human heart. Am Heart J 1993;125:1659-66.
17. Asanoi H, Sasayama S, Kameyama T. Ventriculoarterial coupling in normal and failing heart in humans. Circ Res 1989;65:483-93.
18. Gribbin B, Pickering TG, Sleight P, Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 1971;29:424-31.
19. Seals DR, Taylor JA, Ng AV, Esler MD. Exercise and aging: autonomic control of the circulation (review). Med Sci Sports Exerc 1994;26:568-76.
20. White M, Roden R, Minobe W, et al. Age-related changes in beta-adrenergic neuroeffector systems in the human heart. Circulation 1994;90: 1225-38.
21. Weinberger MH, Fineberg NS. Sodium and volume sensitivity of blood pressure. Age and pressure change over time. Hypertension 1991;18:67-71.
22. Freis ED. Age and antihypertensive drugs (hydrochlorothiazide, bendroflumethiazide, nadolol and captopril). Am J Cardiol 1988;61:117-21.
23. Lipsitz LA. Orthostatic hypotension in the elderly. N Engl J Med 1989;321: 952-7.
24. Vaitkevicius PV, Esserwein DM, Maynard AK, O'Connor FC, Fleg JL. Frequency and importance of postprandial blood pressure reduction in elderly nursing-home patients. Ann Int Med 1991;115:865-70.
25. Szwarc RS, Mickleborough LL, Mizuno S, Silson GJ, Liu P, Mohamed S. Conductance catheter measurements of left ventricular volume in the intact dog: parallel conductance is independent of left ventricular size. Cardiovasc Res 1994;28:252-8.
26. Kass DA, Yamazaki T, Burkhoff D, Maughan WL, Sagawa K. Determination of left ventricular end-systolic pressure-volume relationships by the conductance (volume) catheter technique. Circulation 1986;73:586-95.
27. Sunagawa K, Maughan WL, Burkhoff D, Sagawa K. Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol 1983;245:H773-80.
28. Kelly RP, Ting CT, Yang TM, et al. Effective arterial elastance as index of arterial vascular load in humans. Circulation 1992;86:513-21.
29. de Tombe PP, Jones S, Hunter WC, Burkhoff D, Kass DA, Ventricular stroke work and efficiency remain nearly optimal despite broad changes in ventricular-vascular coupling. Am J Physiol 1993;264:H1817-24.
30. Nichols WW, O'Rourke MF. Aging. In: Nichols WW, O'Rourke MF, editors. McDonald's Blood Flow in Arteries, 4th ed. London: Arnold, 1998:347-76.
31. Peitzman SJ, Berger SR. Postprandial blood pressure decrease in well elderly persons. Arch Intern Med 1989;149:286-8.
32. Cohen-Solal A, Caviezel B, Laperche T, Gourgon R. Effects of aging on left ventricular-arterial coupling in man: assessment by means of arterial effective and left ventricular elastances. J Hum Hypertens 1996;10:111-6.
33. Senzaki H, Chen CH, Kass DA. Single-beat estimation of end-systolic pressure-volume relation in humans. A new method with the potential for noninvasive application. Circulation 1996;94:2497-506.
34. Rodeheffer RJ, Gerstenblith G, Becker LC, Fleg JL, Weisfeldt ML, Lakatta EG. Exercise cardiac output is maintained with advancing age in healthy human subjects: cardiac dilatation and increased stroke volume compensate for a diminished heart rate. Circulation 984;69:203-13.
35. Ooi WL, Barrett S, Hossain M, Kelley-Gagnon MM, Lipsitz LA. Patterns of orthostatic blood pressure change and their clinical correlates in a frail, elderly population. JAMA 1997;277:1299-304.
36. Applegate WB, Davis BR, Black RH, Smith WM, Miller ST, Burlando AJ. Prevalence of postural hypotension at baseline in the Systolic Hypertension in the Elderly Program (SHEP) Cohort. J Am Geriatr Soc 1991;39:1057-64.
37. Shannon RP, Maher KA, Santinga JT, Royal HD, Wei JY. Comparison of differences in the hemodynamic response to passive postural stress in healthy subjects >70 years and <30 years of age. Am J Cardiol 1991;67:1110-6.
38. Law MR, Frost CD, Wald NJ. III-Analysis of data from trials of salt reduction. Br Med J 1991;302:819-24.
39. MRC Working Party. Medical Research Council trial of treatment of hypertension in older adults: principal results. Br Med J 1992;304:405-12.
40. Kajstura J, Cheng W, Sarangarajan R, Li P, et al. Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats. Am J Physiol 1996;271:H1215-28.
41. Suga H, Hisano R, Goto Y, Yamada O. Normalization of end-systolic pressure-volume relation and Emax of different sized hearts. Jpn Circ J 1984;48:136-43.
42. Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio. Circ Res 1973;32:314-22.
43. Suga H, Sagawa K. Instantaneous pressure-volume relationships and their ratio in the exercised, supported canine left ventricle. Circ Res 1974;35:117-26.