Reduced Frequency of Regulatory T Cells in Peripheral Blood Stem Cell Compared to Bone Marrow Transplantations

Biology of Blood and Marrow Transplantation

Volumn 16, Issue 3, 2010, Pages 430-434

  Blache, Céline ^a   Chauvin, Joe Marc ^a   Marie Cardine, Aude ^b   Contentin, Nathalie ^c   Pommier, Pascal ^d   Dedreux, Ingrid ^a   François, Stéphanie ^a   Jacquot, Serge ^a   Bastit, Dominique ^d   Boyer, Olivier ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b ROUEN UNIVERSITY HOSPITAL   (France)

^c CENTRE HENRI BECQUEREL   (France)

^d ETABLISSEMENT FRANÇAIS DU SANG   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; L SELECTIN;

ARTICLE; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; GRAFT VERSUS HOST REACTION; HIGH RISK POPULATION; HUMAN; INTERMETHOD COMPARISON; LEUKAPHERESIS; LYMPHOCYTE COUNT; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PHENOTYPE; REGULATORY T LYMPHOCYTE; RISK ASSESSMENT;

ANTIGENS, CD45; APOPTOSIS; BONE MARROW; BONE MARROW TRANSPLANTATION; FORKHEAD TRANSCRIPTION FACTORS; GRAFT VS HOST DISEASE; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-7 RECEPTOR ALPHA SUBUNIT; L-SELECTIN; LEUKAPHERESIS; LYMPHOCYTE COUNT; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; RISK FACTORS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS;

EID: 75949129622     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.10.027     Document Type: Article

References (30)

1. Sakaguchi S., Yamaguchi T., Nomura T., and Ono M. Regulatory T cells and immune tolerance. Cell 133 (2008) 775-787
2. Boyer O., Saadoun D., Abriol J., et al. CD4 + CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis. Blood 103 (2004) 3428-3430
3. Viglietta V., Baecher-Allan C., Weiner H.L., and Hafler D.A. Loss of functional suppression by CD4 + CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 199 (2004) 971-979
4. Cohen J.L., and Boyer O. The role of CD4 + CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease. Curr Opin Immunol 18 (2006) 580-585
5. Rezvani K., Mielke S., Ahmadzadeh M., et al. High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 108 (2006) 1291-1297
6. Pabst C., Schirutschke H., Ehninger G., Bornhauser M., and Platzbecker U. The graft content of donor T cells expressing gamma delta TCR+ and CD4+foxp3+ predicts the risk of acute graft versus host disease after transplantation of allogeneic peripheral blood stem cells from unrelated donors. Clin Cancer Res 13 (2007) 2916-2922
7. Wolf D., Wolf A.M., Fong D., et al. Regulatory T-cells in the graft and the risk of acute graft-versus-host disease after allogeneic stem cell transplantation. Transplantation 83 (2007) 1107-1113
8. Miura Y., Thoburn C.J., Bright E.C., et al. Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood 104 (2004) 2187-2193
9. Cohen J.L., Trenado A., Vasey D., Klatzmann D., and Salomon B.L. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med 196 (2002) 401-406
10. Hoffmann P., Ermann J., Edinger M., Fathman C.G., and Strober S. Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196 (2002) 389-399
11. Taylor P.A., Lees C.J., and Blazar B.R. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99 (2002) 3493-3499
12. Trenado A., Charlotte F., Fisson S., et al. Recipient-type specific CD4 + CD25+ regulatory T cells favor immune reconstitution and control graft-versus-host disease while maintaining graft-versus-leukemia. J Clin Invest 112 (2003) 1688-1696
13. Riley J.L., June C.H., and Blazar B.R. Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity 30 (2009) 656-665
14. Fu S., Yopp A.C., Mao X., et al. CD4 + CD25 + CD62 + T-regulatory cell subset has optimal suppressive and proliferative potential. Am J Transplant 4 (2004) 65-78
15. Taylor P.A., Panoskaltsis-Mortari A., Swedin J.M., et al. L-Selectin(hi) but not the L-selectin(lo) CD4 + 25 + T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 104 (2004) 3804-3812
16. Ermann J., Hoffmann P., Edinger M., et al. Only the CD62L+ subpopulation of CD4 + CD25+ regulatory T cells protects from lethal acute GVHD. Blood 105 (2005) 2220-2226
17. Seddiki N., Santner-Nanan B., Tangye S.G., et al. Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 107 (2006) 2830-2838
18. Sugimori N., Nakao S., Yachie A., et al. Administration of G-CSF to normal individuals diminishes L-selectin+ T cells in the peripheral blood that respond better to alloantigen stimulation than L-selectin- T cells. Bone Marrow Transplant 23 (1999) 119-124
19. Gu B., Bendall L.J., and Wiley J.S. Adenosine triphosphate-induced shedding of CD23 and L-selectin (CD62L) from lymphocytes is mediated by the same receptor but different metalloproteases. Blood 92 (1998) 946-951
20. Seman M., Adriouch S., Scheuplein F., et al. NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor. Immunity 19 (2003) 571-582
21. Moir S., Donoghue E.T., Pickeral O.K., et al. Continuous flow leukapheresis induces expression of stress genes in lymphocytes: impact on microarray analyses. Blood 102 (2003) 3852-3853
22. Aswad F., Kawamura H., and Dennert G. High sensitivity of CD4 + CD25+ regulatory T cells to extracellular metabolites nicotinamide adenine dinucleotide and ATP: a role for P2X7 receptors. J Immunol 175 (2005) 3075-3083
23. Tayebi H., Kuttler F., Saas P., et al. Effect of granulocyte colony-stimulating factor mobilization on phenotypical and functional properties of immune cells. Exp Hematol 29 (2001) 458-470
24. Rutella S., Pierelli L., Bonanno G., et al. Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells. Blood 100 (2002) 2562-2571
25. Vela-Ojeda J., Esparza M.A., Reyes-Maldonado E., et al. CD4 + CD25+ lymphocyte and dendritic cell mobilization with intermediate doses of recombinant human granulocyte colony-stimulating factor in healthy donors. Stem Cells Dev 14 (2005) 310-316
26. Morris E.S., MacDonald K.P., and Hill G.R. Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?. Blood 107 (2006) 3430-3435
27. Noel G., Bruniquel D., DeGuibert S., et al. Regulatory CD4 + CD25hi T cells conserve their function and phenotype after granulocyte colony-stimulating factor treatment in human hematopoietic stem cell transplantation. Hum Immunol 69 (2008) 329-337
28. Cutler C., Giri S., Jeyapalan S., Paniagua D., Viswanathan A., and Antin J.H. Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: a meta-analysis. J Clin Oncol 19 (2001) 3685-3691
29. Schmitz N., Eapen M., Horowitz M.M., et al. Long-term outcome of patients given transplants of mobilized blood or bone marrow: a report from the International Bone Marrow Transplant Registry and the European Group for Blood and Marrow Transplantation. Blood 108 (2006) 4288-4290
30. Stem-Cell-Trialists'-Collaborative-Group. Allogeneic peripheral blood stem-cell compared with bone marrow transplantation in the management of hematologic malignancies: an individual patient data meta-analysis of nine randomized trials. J Clin Oncol 23 (2005) 5074-5087