Novel dinuclear platinum(II) complexes targets NFκB signaling pathway to induce apoptosis and inhibit metabolism of MCF-7 breast cancer cells

Folia Histochemica et Cytobiologica

Volumn 47, Issue 5, 2009, Pages

  Popławska, Bozena ^a   Bielawska, Anna ^a   Surazyński, Arkadiusz ^a   Czarnomysy, Robert ^a   Bielawski, Krzysztof ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Apoptosis; Breast cancer cells; Collagen biosynthesis; Dinuclear platinum(II) complexes; IGF I receptor; NF B signaling

Indexed keywords

3 PICOLINE; AMINE; BETA1 INTEGRIN; CISPLATIN; COLLAGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOPROPYLAMINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PICOLINE; PICOLINE DERIVATIVE; PIPERAZINE; PLATINUM DERIVATIVE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PLATINUM; PLATINUM COMPLEX;

APOPTOSIS; ARTICLE; CELL METABOLISM; CELL PROLIFERATION; CELL STRAIN MCF 7; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA FRAGMENTATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INCUBATION TIME; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BREAST TUMOR; CHEMISTRY; DRUG EFFECTS; MCF 7 CELL LINE; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; HUMANS; MCF-7 CELLS; NF-KAPPA B; ORGANOPLATINUM COMPOUNDS; PLATINUM; SIGNAL TRANSDUCTION;

EID: 75949094389     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10042-009-0084-1     Document Type: Article

References (36)

1. Brabec V, Kasparkova J. Modifications of DNA by platinum complexes: Relation to resistance of tumors to platinum antitumor drugs. Drug Resist Updates. 2005;8:131-146.
2. Wong E, Giandomenico CM. Current Status of Platinum-Based Antitumor Drugs. Chem Rev. 1999;99:2451-2466.
3. Rosenberg B, Camp L, Trosko JE. Mansour VH. Platinum compounds: a new class of potent antitumor agents. Nature. 1996;222:385-386.
4. Mukhopadhyay R, Dubey P, Sarkar S. Structural changes of DNA induced by mono-and binuclear cancer drugs. J Struct Biol. 2005;150:277-283.
5. Kasparkova J, Vrana O, Farrell N, Brabec V. Effect of the geometry of the central coordination sphere in antitumor trinuclear platinum complexes on DNA binding. J Inorg Biochem. 2004;98:1560-1569.
6. Bielawski K, Bielawska A, Słodownik T, Popawska B, Bołkun-Skórnicka U. DNA-binding activity and cytotoxicity of Pt-berenil compounds in MDA-MB-231 and MCF-7 breast cancer cells. Acta Pol Pharm Drug Res. 2008;65:135-140.
7. Bielawski K, Bielawska A, Popawska B, Bołkun-Skórnicka U. Synthesis, DNA-binding affinity and cytotoxicity of the dinuclear platinum(II) complexes with berenil and amines ligands. Acta Pol Pharm Drug Res. 2008;65:363-370.
8. Goldstein RH, Poliks CF, Plich PF, Smith BD, Fine A. Stimulation of collagen formation by insulin-like growth factor-I in cultures of human lung fibroblasts. Endocrinology. 1989;124:964-970.
9. Hanks SK, Calalb MB, Harper MC, Patel SK. Focal adhesion protein-tyrosine kinase phosphotylated in response to cell attachment to fibronectin. Proc Natl Acad Sci USA. 1992;89:8487-8491
10. Juliano R. Cooperation between soluble factors and integrinmediated cell anchorage in the control of cell growth and differentiation. Bioessays. 1996;18:911-917
11. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J. 1995;9:726-735
12. Butler AA, Shoshana Y, Gewolb IH, Karas M, Okubo Y, LeRoith D. Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comp Biochem Physiol B. 1998;121:19-26.
13. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed GC. Regulation of cell death protease caspase-9 by phosphorylation. Science. 1998;282: 1318-1321.
14. Datta SR, Dudek HTX, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell. 1997;91:231-241.
15. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 2000;10761-10766
16. Barcelo F, Ortiz-Lombardia M, Portugal J. Heterogeneous DNA binding modes of berenil. Biochim Biophys Acta. 2001;1519:175-184.
17. Nguyen B, Hamelberg D, Bailly Ch, Colson P, Stanek J, Brun R, Neidle S, Wilson WD. Characterization of a novel DNA minor-groove complex. Biophys J. 2004;86: 1028-1041.
18. Denny WA. DNA minor groove alkylating agents. Curr Med Chem. 2001;8:533-544
19. Bartulewicz D, Bielawski K, Bielawska A, Róañski A. Synthesis, molecular modelling, and antiproliferative and cytotoxic effects of carbocyclic derivatives of distamycin with chlorambucil moiety. Eur J Med Chem. 2001;36:461-467
20. Bielawska A, Bielawski K, Wołczyñski S, Anchim T. Structure-Activity studies of novel amidine analogues of chlorambucil: correlation of cytotoxic activity with DNA-binding and topoisomerase II inhibition. Arch Pharm Med Chem. 2003; 336:293-299
21. Oyamada I, Pałka J, Schalk EM, Takeda K, Peterkofsky B. Scorbutic and fasted guinea pig sera contain an insulin-like growth factor I reversible inhibitor of proteoglycan and collagen synthesis in chick embryo chondrocytes and adult human skin fibroblasts. Arch Biochem Biophys. 1990;276:85-93.
22. Peterkofsky B, Pałka J, Wilson S, Takeda K, Shah V. Elevated activity of low molecular weight insulin-like growth factor-binding proteins in sera of vitamin C-deficient and fasted guinea pigs. Endocrinology. 1991;128:1769-1779
23. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227:680-685
24. Martin SJ, Reutelingsperger CP, McGahon, AJ, Rader JA, van Schie RC, LaFace DM, Green DR. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med. 1995;182:1545-1556.
25. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 1995;184: 39-51.
26. Cohen JJ, Duke RC, Fadok VA, Sellins KS. Apoptosis and programmed cell death in immunity. Annu Rev Immunol. 1992;10:267-293.
27. Boudreau N, Bissel MJ. Extracellular matrix signaling: integration of form and function in normal and malignant cells. Curr Opin Cell Biol. 1998;10:640-646
28. Albeda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J. 1990;4:2868-2880
29. Ioachim E, Charchanti A, Briasoulis E, Karavasilis V, Tsanou H, Arvanitis DL. Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur J Cancer. 2002;38: 2362-2370
30. Perumpanani, AJ, Byrne HM. Extracellular matrix concentration exerts selection pressure on invasive cells. Eur J Cancer. 1999;35:1274-1280
31. Boudreau N, Sympson CJ, Werb Z, Bissel M. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science. 1995;267:891-893
32. Labat-Robert J, Robert L. Interaction between cells and extracellular matrix: signaling by integrins and the elastin-laminin receptor. Prog Mol Subcell Biol. 2000;25:57-70.
33. Kouba DJ, Chung KY, Nishiyama T, Vindevoghel L, Kon A, Klement JF, Uitto J, Mauviel A. Nuclear factor-kappa B mediates TNF-alpha inhibitory effect on alpha 2(I) collagen (COL1A2) gene transcription in human dermal fibroblasts. J Immunol. 1999;162:4226-4234
34. Rippe RA, Schrum LW, Stefanovic B, Solís-Herruzo JA, Brenner DA. NF-kappaB inhibits expression of the alpha1(I) collagen gene. DNA Cell Biol. 1999;18:751-761
35. Miltyk W, Karna E, Palka JA. Prolidase-independent mechanizm of camptothecin-induced inhibition of collagen biosynthesis in cultured human skin fibroblasts. J Biochem. 2007;141:287-292.
36. Kumar A, Takada Y, Boriek AM, Aggarwal BB. Nuclear factor-κ B: its role in health and disease. J Mol Med. 2004; 82:434-448