Programmable nano-bio-chips: Multifunctional clinical tools for use at the point-of-care

Nanomedicine

Volumn 5, Issue 1, 2010, Pages 143-155

  Jokerst, Jesse V ^a,b   McDevitt, John T ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RICE UNIVERSITY   (United States)

Author keywords

Integrated sensor; Lab on a chip; Moore's law; Nano bio chip; Point of care; Programmable

Indexed keywords

ARTICLE; BIOASSAY; BIOCHEMICAL EQUIPMENT; BIOCHIP; CANCER DIAGNOSIS; CLINICAL ASSESSMENT TOOL; COMPUTER PROGRAM; COST EFFECTIVENESS ANALYSIS; DIAGNOSTIC ACCURACY; EQUIPMENT DESIGN; GOLD STANDARD; HEALTH CARE ACCESS; HEALTH CARE COST; HEART DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTERMETHOD COMPARISON; LAB ON A CHIP; MICROFLUIDICS; NANOFABRICATION; NANOMEDICINE; NANOSENSOR; NANOTECHNOLOGY; PARTICLE SIZE; PATIENT CARE; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROGNOSIS; QUALITY CONTROL; SENSITIVITY AND SPECIFICITY; SYSTEM ANALYSIS; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS;

BIOSENSING TECHNIQUES; DNA; EQUIPMENT DESIGN; NANOTECHNOLOGY; PROTEINS; SOFTWARE;

EID: 75949088909     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.09.94     Document Type: Article

References (71)

1. Hanash SM, Pitteri SJ, Faca VM: Mining the plasma proteome for cancer biomarkers. Nature 452(7187), 571-579 (2008).
2. Hunter DJ, Khoury MJ, Drazen JM: Perspective: letting the genome out of the bottle - will we get our wish? N. Engl. J. Med. 358(2), 105-107 (2008).
3. Anderson NL, Anderson NG: The human plasma proteome. History, character, and diagnostic prospects. Mol. Cell. Proteomics 1(11), 845-867 (2002).
4. Vitzthum F, Behrens F, Anderson NL, Shaw JH: Proteomics: from basic research to diagnostic application. A review of requirements and needs. J. Proteome Res. 4(4), 1086-1097 (2005).
5. Yager P, Edwards T, Fu E et al.: Microfluidic diagnostic technologies for global public health. Nature 442(7101), 412-418 (2006).
6. Soper SA, Brown K, Ellington A et al.: Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosens. Bioelectron. 21(10), 1932-1942 (2006).
7. Myers FB, Lee LP: Innovations in optical microfluidic technologies for point-of-care diagnostics. Lab Chip 8(12), 2015-2031 (2008).
8. Ouellette AL, Li JJ, Cooper DE, Ricco AJ, Kovacs GTA: Evolving point-of-care diagnostics using up-converting phosphor bioanalytical systems. Anal. Chem. 81(9), 3216-3221 (2009).
9. Osterfeld SJ, Yu H, Gaster RS, et al.: Multiplex protein assay based on real-time magnetic nanotag sensing. Proc. Natl Acad. Sci. USA 105(52), 20637-20640 (2008).
10. Thorsen T, Maerkl Sebastian J, Quake Stephen R: Microfluidic large-scale integration. Science 298(5593), 580-584 (2002).
11. Whitesides GM: The origins and the future of microfluidics. Nature 442(7101), 368-373 (2006).
12. Vilkner T, Janasek D, Manz A: Micro total ana lysis systems. Recent developments. Anal. Chem. 76(12), 3373-3385 (2004).
13. Mukhopadhyay R: Microfluidics: on the slope of enlightenment. Anal. Chem. 81(11), 4169-4173 (2009).
14. Ligler FS: Perspective on optical biosensors and integrated sensor systems. Anal. Chem. 81(2), 519-526 (2009).
15. Toriello NM, Douglas ES, Thaitrong N, et al.: Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc. Natl Acad. Sci. USA 105(51), 20173-20178 (2008).
16. Sia SK, Kricka LJ: Microfluidics and point-of-care testing. Lab Chip 8(12), 1982-1983 (2008).
17. McCarley RL, Vaidya B, Wei SY et al.: Resist-free patterning of surface architectures in polymer-based microanalytical devices. J. Am. Chem. Soc. 127(3), 842-843 (2005).
18. Madou M, Zoval J, Jia G et al.: Lab on a CD. Annu. Rev. Biomed. Eng. 8, 601-628 (2006).
19. Waggoner PS, Craighead HG: Micro- and nanomechanical sensors for environmental, chemical, and biological detection. Lab Chip 7(10), 1238-1255 (2007).
20. de Mello AJ, Wootton RCR: Chemistry at the crossroads. Nat. Chem. 1(1), 28-29 (2009).
21. Sanhai WR, Sakamoto JH, Canady R, Ferrari M: Seven challenges for nanomedicine. Nat. Nanotech. 3(5), 242-244 (2008).
22. Melin J, Quake SR: Microfluidic large-scale integration: the evolution of design rules for biological automation. Annu. Rev. Biophys. Biomol. Struc. 36, 213-231 (2007).
23. Holmesfarley SR, Bain CD, Whitesides GM: Wetting of functionalized polyethylene film having ionizable organic-acids and bases at the polymer water interface - relations between functional-group polarity, extent of ionization, and contact-angle with water. Langmuir 4(4), 921-937 (1988).
24. Goluch ED, Nam J-M, Georganopoulou DG et al.: A bio-barcode assay for on-chip attomolar-sensitivity protein detection. Lab Chip 6(10), 1293-1299 (2006).
25. Qin L, Vermesh O, Shi Q, Heath JR: Self-powered microfluidic chips for multiplexed protein assays from whole blood. Lab Chip 9(14), 2016-2020 (2009).
26. Srivastava N, Brennan JS, Renzi RF et al.: Fully integrated microfluidic platform enabling automated phosphoprofiling of macrophage response. Anal. Chem. 81(9), 3261-3269 (2009).
27. Chin CD, Linder V, Sia SK: Lab-on-a-chip devices for global health: Past studies and future opportunities. Lab Chip 7(1), 41-57 (2007).
28. Kim JS, Anderson GP, Erickson JS et al.: Multiplexed detection of bacteria and toxins using a microflow cytometer. Anal. Chem. 81(13), 5426-5432 (2009).
29. Walt DR: Chemistry: miniature analytical methods for medical diagnostics. Science 308(5719), 217-219 (2005).
30. Cheng X, Gupta A, Chen C et al.: Enhancing the performance of a point-of-care CD4+ T-cell counting microchip through monocyte depletion for HIV/AIDS diagnostics. Lab Chip 9(10), 1357-1364 (2009).
31. Maheswaran S, Sequist LV, Nagrath S et al.: Detection of mutations in EGFR in circulating lung-cancer. N. Engl. J. Med. 359(4), 366-377 (2008).
32. Mukhopadhyay R: When microfluidic devices go bad. Anal. Chem. 77(21), 429A-432A (2005).
33. Janasek D, Franzke J, Manz A: Scaling and the design of miniaturized chemical-ana lysis systems. Nature 442(7101), 374-380 (2006).
34. Rodriguez WR, Christodoulides N, Floriano PN et al.: A microchip CD4 counting method for HIV monitoring in resource-poor settings. PLoS Med. 2(7), e182 (2005).
35. Jokerst JV, Raamanathan A, Christodoulides N et al.: Nano-bio-chips for high performance multiplexed protein detection: determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels. Biosens. Bioelectron. 24(12), 3622-3629 (2009).
36. Jokerst JV, Floriano PN, Christodoulides N, Simmons GW, McDevitt JT: Integration of semiconductor quantum dots into nano-biochip systems for enumeration of CD4+ T cell counts at the point-of-need. Lab Chip 8(12), 2079-2090 (2008).
37. Goodey A, Lavigne JJ, Savoy SM et al.: Development of multianalyte sensor arrays composed of chemically derivitized polymeric microspheres localized in micromachined cavities. J. Am. Chem. Soc. 123 2559-2570 (2001).
38. Lavigne JJ, Savoy S, Clevenger MB et al.: Solution-based ana lysis of multiple analytes by a sensor array: toward the development of an 'electronic tongue'. J. Am. Chem. Soc. 120(25), 6429-6430 (1998).
39. Kilby JSC: Turning potential into realities: the invention of the integrated circuit. ChemPhysChem 2(8/9), 482-489 (2001).
40. Floriano P, Christodoulides N, Miller C et al.: Use of saliva-based nano-biochip tests for acute myocardial infarction at the point of care: a feasibility study. Clin. Chem. 55(8), 1530-1538 (2009).
41. Weigum SE, Floriano PN, Christodoulides N, McDevitt JT: Cell-based sensor for ana lysis of EGFR biomarker expression in oral cancer. Lab Chip 7(8), 995-1003 (2007).
42. Christodoulides N, Floriano PN, Acosta SA et al.: Toward the development of a lab-on-a-chip dual-function leukocyte and C-reactive protein ana lysis method for the assessment of inflammation and cardiac risk. Clin. Chem. 51(12), 2391-2395 (2005).
43. Ali MF, Kirby R, Goodey AP et al.: DNA hybridization and discrimination of single-nucleotide mismatches using chip-based microbead arrays. Anal. Chem. 75, 4732-4739 (2003).
44. Agnew HD, Rohde RD, Millward SW et al.: Iterative in situ click chemistry creates antibody-like protein-capture agents. Angew. Chem. Int. Ed. 48(27), 4944-4948 (2009).
45. Christodoulides N, Dharshan P, Wong J et al.: A microchip-based assay for interleukin-6. Meth. Mol. Bio. 385, 131-144 (2007).
46. Gustavsson P-E, Axelsson A, Larsson P-O: Superporous agarose beads as a hydrophobic interaction chromatography support. J. Chromatography A 830(2), 275-284 (1999).
47. McCleskey SC, Griffin MJ, Schneider SE, McDevitt JT, Anslyn EV: Differential receptors create patterns diagnostic for ATP and GTP. J. Am. Chem. Soc. 125(5), 1114-1115 (2003).
48. Wright AT, Anslyn EV, McDevitt JT: A differential array of metalated synthetic receptors for the ana lysis of tripeptide mixtures. J. Am. Chem. Soc. 127(49), 17405-17411 (2005).
49. Christodoulides N, Mohanty S, Miller CS, et al.: Application of microchip assay system for the measurement of C-reactive protein in human saliva. Lab Chip 5(3), 261-269 (2005).
50. Jackson DJ, Naber JF, Roussel TJ, et al.: Portable high-voltage power supply and electrochemical detection circuits for microchip capillary electrophoresis. Anal. Chem. 75(14), 3643-3649 (2003).
51. Christodoulides N, Floriano PN, Miller CS et al.: Lab-on-a-chip methods of point-of-care measurements of salivary biomarkers of periodontitis. Ann. NY Acad. Sci. 1098, 411-428 (2007).
52. Christodoulides N, Tran M, Floriano PN et al.: A microchip-based multianalyte assay system for the assessment of cardiac risk. Anal. Chem. 74(13), 3030-3036 (2002).
53. Curey T, Goodey A, Tsao A et al.: Characterization of multicomponent monosaccharide solutions using an enzymebased sensor array. Anal. Biochem. 293(2), 178-184 (2001).
54. Goodey A, Lavigne JJ, Savoy SM et al.: Development of multianalyte sensor arrays composed of chemically derivatized polymeric microspheres localized in micromachined cavities. J. Am. Chem. Soc. 123(11), 2559-2570 (2001).
55. Goodey AP, McDevitt JT: Multishell microspheres with integrated chromatographic and detection layers for use in array sensors. J. Am. Chem. Soc. 125(10), 2870-2871 (2003).
56. Kirby R, Cho EJ, Gehrke B et al.: Aptamerbased sensor arrays for the detection and quantitation of proteins. Anal. Chem. 76(14), 4066-4075 (2004).
57. Wong DT: Salivary diagnostics powered by nanotechnologies, proteomics and genomics. JADA 137(3), 313-321 (2006).
58. Herr AE, Hatch AV, Throckmorton DJ et al.: Microfluidic immunoassays as rapid saliva-based clinical diagnostics. Proc. Natl Acad. Sci. USA 104(13), 5268-5273 (2007).
59. Cohen J: Monitoring treatment: at what cost? Science 304(5679), 1936-1936 (2004).
60. CDC: 1997 revised guidelines for performing CD4+ T-cell determinations in persons infected with human immunodeficiency virus (HIV). MMWR Morb. Mortal. Wkly. Rep. 46(RR-2), 1-29 (1997).
61. Rodriguez WR, Christodoulides N, Floriano PN et al.: A microchip CD4 counting method for HIV monitoring in resource-poor settings. PloS Med. 2(7), 663-672 (2005).
62. Floriano PN, Christodoulides N, Romanovicz DK et al.: Membrane-based on-line optical ana lysis system for rapid detection of bacteria and spores. Biosens. Bioelectron. 20(10), 2079-2088 (2005).
63. Ginsburg PB, Strunk BC, Banker MI, Cookson JP: Tracking health care costs: continued stability but at high rates in 2005. Health Aff. 25(6), w486-w495 (2006).
64. Kineiko RW, Floering DA, Morrissey M: Laboratory evaluation of the Boehringer Mannheim 'Hitachi 705' automatic analyzer. Clin. Chem. 29(4), 688-691 (1983).
65. Erickson KA, Wilding P: Evaluation of a novel point-of-care system, the i-STAT portable clinical analyzer. Clin. Chem. 39(2), 283-287 (1993).
66. Fulton RJ, McDade RL, Smith PL, Kienker LJ, Kettman JR Jr: Advanced multiplexed ana lysis with the FlowMetrix system. Clin. Chem. 43(9), 1749-1756 (1997).
67. LabNow. www.labnow.com/ (Accessed 07/30/2009).
68. NIH. http://tinyurl.com/yfz8352.
69. Affymetrix. http://tinyurl.com/yh3yn43.
70. Affymetrix. http://tinyurl.com/ygxbks8.
71. McDevitt Research Laboratory. http://www.tastechip.com