ACAT-1, Cav-1 and PrP expression in scrapie susceptible and resistant sheep

Central European Journal of Biology

Volumn 5, Issue 1, 2010, Pages 31-37

  Orrù, Cristina D ^a   Abete, Claudia ^a   Cannas, M Dolores ^a   Mulas, Claudia ^a   Norfo, Claudia ^a   Mandas, Antonella ^a   Vascellari, Sarah ^a   La Colla, Paolo ^a   Dessì, Sandra ^a   Pani, Alessandra ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Cholesterol esters; Cholesterol homeostasis; Prion diseases; Scrapie

Indexed keywords

ANIMALIA; OVIS ARIES;

EID: 75849161806     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-009-0076-3     Document Type: Article

References (30)

1. Prusiner S. B., Prions, Proc. Natl. Acad. Sci. USA, 1998, 95, 13363-13383.
2. Gorodinsky A., Harris D. A., Glycolipid-anchored proteins in neuroblastoma cells form detergent-resistant complexes without caveolin, J. Cell Biol., 1995, 129, 619-627.
3. Loberto N., Prioni S., Bettiga A., Chigorno V., Prinetti A., Sonnino S., The membrane environment ofendogenous cellular prion protein in primary rat cerebellar neurons., J. Neurochem., 2005, 95, 771-783.
4. Kurzchalia T. V., Parton R. G., Membrane microdomains and caveolae, Curr. Op. Cell Biol., 1999, 11, 424-431.
5. Vey M., Pilkuhn S., Wille H., Nixon R., DeArmond S. J., Smart E. J., et al., Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains, Proc. Natl. Acad. Sci. USA, 1996, 93, 14945-14949.
6. Simons K., Ehehalt R., Cholesterol, lipid raft and disease, J. Clin. Invest., 2002, 110, 597-603.
7. Taraboulos A., Scott M., Semenov A., Avrahami D., Laszlo L., Prusiner S. B., Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform, J. Cell Biol., 1995, 129, 121-132.
8. Diomede L., Forloni G., Bugiani O., Tagliavini F., Salmona M., The prion protein and cellular cholesterol homeostasis, Neurobiol. Lipids, 2002, 1, 8-14.
9. Prado A. M., Silva J. A., Magalhaes A. C., Prado V. F., Linden R., Martins V. R., et al., PrPc on the road: trafficking of the cellular prion protein, J. Neurochem., 2004, 88, 769-781.
10. Critchley P., Kazlauskaite J., Eason R., Pinheiro T. J., Binding of prion protein to lipid membranes, Biochem. Biophys. Res. Commun., 2004, 313, 559-567.
11. Schmitz G., Orso E., Intracellular Cholesterol and Phospholipid Trafficking: Comparable Mechanisms in Macrophages and Neuronal Cells, Cell Mol. Life Sci., 2001, 26, 1045-1068.
12. Maxfield, F. R., Tabas I., Role of cholesterol and lipid organization in disease, Nature, 2005, 438, 612-621.
13. Simons K., Ikonen E., How cell handle cholesterol, Science, 2000, 290, 1721-1726.
14. Binder W. H., Barragan V., Menger F. M., Domains and raft in lipid membrane. Angewandte chemie-international edition, 2003, 42, 5802-5827.
15. Pani A., Abete C., Norfo C., Mulas C., Laconi S., Cannas M. D., et al., Cholesterol Metabolism in Brain and Skin Fibroblasts from Sarda Breed Sheep With Scrapie-resistant and Scrapie-susceptible Genotypes, Am. J. Infec. Dis., 2007, 3, 143-150.
16. Pani A., Norfo C., Abete C., Mulas C., Putzolu M., Laconi S., et al., Accumulation of Cholesterol Esters in ex vivo Lymphocytes from Scrapie-susceptible Sheep and in Scrapie-infected Mouse Neuroblastoma Cell Lines, Am. J. Infec. Dis., 2007, 3, 165-168.
17. Pani A., Norfo C., Abete C., Mulas C., Putzolu M., Laconi S., et al., Anti-prion activity of cholesterol esterification modulators: a comparative study in ex vivo sheep fibroblasts and lymphocytes and in mouse neuroblastoma cell lines, Antimicrob. Agents Chemother., 2007, 51, 4141-4147.
18. Bate C., Williams A., Role of glycosylphosphatidylinositols in the activation of phospholipase A2 and the neurotoxicity of prions, J. Gen. Virol., 2004, 85, 3797-3804.
19. Gilch S., Kehler C., Schätzl H. M., The prion protein requires cholesterol for cell surface localization, Mol. Cell. Neurosci., 2006, 31, 346-353.
20. Mok S. W., Thelen K. M., Riemer C., Bamme T., Gültner S., Lütjohann D., et al., Simvastatin prolongs survival times in prion infections of the central nervous system, Biochem. Biophys. Res. Commun., 2006, 348, 697-702.
21. Pani A., Dessì S., Cell Growth and Cholesterol Esters, Kluwer Academic Press/Plenum Publishers, New York, NY, USA, 2004.
22. Soto C., Castilla J., The controversial protein-only hypothesis of prion propagation, Nat. Med., 2004, 10, S63-S67.
23. Wickner R. B., Edskes H. K., Roberts B. T., Baxa U., Pierce M. M., Ross E. D., et al., Prions: proteins as genes and infectious entities, Genes Dev., 2004, 18, 470-485.
24. Goldmann W., Baylis M., Chihota C., Stevenson E., Hunter N., Frequencies of PrP gene haplotypes in British sheep flocks and the implications for breeding programmes, J. Appl. Microbiol., 2005, 98, 1294-1302.
25. Safar J. G., Wille H., Geschwind M. D., Deering C., Latawiec D., Serban A., et al., Human prions and plasma lipoproteins, Proc. Natl. Acad. Sci. USA, 2006, 103, 11312-11317.
26. Harris D. A., Trafficking, turnover and membrane topology of PrP, Brit. Med. Bull., 2003, 66, 71-85.
27. Sarnataro D., Campana V., Paladino S. M., Stornaiuolo M., Nitsch L., Zurzolo C., PrPC Association with Lipid Rafts in the Early Secretory Pathway Stabilizes Its cellular conformation, Mol. Biol. Cell., 2004, 15, 4031-4042.
28. Campana V., Sarnataro D., Fasano C., Casanova P., Paladino S., Zurzolo C., Detergent-resistant membrane domains but not the proteasome are involved in the misfolding of a PrP mutant retained in the endoplasmic reticulum, J. Cell Sci., 2006, 119, 433-442.
29. Abid K., Soto C., The intriguing prion disorders, Cell. Mol. Life Sci., 2006, 63, 2342-2351.
30. Russelakis-Carneiro M., Hetz C., Maundrell K., Soto C. Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts, Am. J. Pathol., 2004, 165, 1839-1848.