Screening of kit inhibitors: Suppression of kit signaling and melanogenesis by emodin

Phytotherapy Research

Volumn 24, Issue 2, 2010, Pages 308-312

  Lee, Seong Jin ^a   Jeong, Daeyoung ^a   Park, Woo Kyu ^a   Kong, Jae Yang ^a   Choi, Gildon ^a   Kim, Hojeong ^b   Kang, Sangjin ^b   Cho, Heeyeong ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b LG Household and Healthcare Ltd   (South Korea)

Author keywords

Emodin; Kit; Melanogenesis; Pigment; RTK inhibitor

Indexed keywords

4 (6,7 DIMETHOXY 4 QUINAZOLINYL) N (4 PHENOXYPHENYL) 1 PEPERAZINECARBOXAMIDE; ALOE EMODIN; BAICALIN; C 521232; CHRYSIN; EMODIN; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MELANIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; QUERCETIN; RECEPTOR BLOCKING AGENT; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; TYROSINE KINASE RECEPTOR; TYRPHOSTIN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IC 50; MELANOCYTE; MELANOGENESIS; NEWBORN; NONHUMAN; PHARMACOLOGICAL BLOCKING; PIGMENT CELL; PROTEIN PHOSPHORYLATION; SCREENING TEST; SCUTELLARIA; SENNA; SIGNAL TRANSDUCTION;

CELL DIFFERENTIATION; CELL PROLIFERATION; EMODIN; HUMANS; MELANINS; MELANOCYTES; MOLECULAR STRUCTURE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION;

ALOE; SCUTELLARIA RADIX;

EID: 75849140012     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2928     Document Type: Article

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