Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 1107-1112

  Koufaki, Maria ^a   Theodorou, Elissavet ^a   Alexi, Xanthippi ^a   Nikoloudaki, Faidra ^a   Alexis, Michael N ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Neuronal cell damage; Oxidative stress; Tropolone

Indexed keywords

1 (4 ISOPROPYL 6 HYDROXY 7 OXO 1,3,5 CYCLOHEPTATRIENYLMETHYL) 4 (4 NITROPHENYL)PIPERAZINE; 1,4 BIS (6 HYDROXY 4 ISOPROPYL 7 OXO 1,3,5 CYCLOHEPTATRIENYLMETHYL)PIPERAZINE; 2 HYDROXY 4 ISOPROPYL 2,4,6 CYCLOHEPTATRIEN 1 ONE; 4 (4 ISOPROPYL 6 HYDROXY 7 OXO 1,3,5 CYCLOHEPTATRIENYLMETHYL)MORPHOLINE; 4 (6 HYDROXY 4 ISOPROPYL 7 OXO 1,3,5 CYCLOHEPTATRIENYL METHYL) 1 PIPERAZINE CARBOXYLIC ESTER; 4 (6 HYDROXY 4 ISOPROPYL 7 OXO 1,3,5 CYCLOHEPTATRIENYLMETHYL) 1 (4 NITROBENZYL)PIPERAZINE; 4 ISOPROPYL 2 METHOXY 7 (PYRIDIN 2 YLOXY)METHYL 2,4,6 CYCLOHEPTATRIEN 1 ONE; 4 ISOPROPYL 2 METHOXY 7 (PYRIDINE 2 YLOXY)METHYL 2,4,6 CYCLOHEPTATRIEN 1 ONE; 7 [(4 BENZYL 1H 1,2,3 TRIAZOL 1 YL)METHYL] 4 ISOPROPYL 2 METHOXY 2,4,6 CYCLOHEPTATRIEN 1 ONE; 7 [[4 (3,4 DIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL]METHYL] 4 ISOPROPYL 2 METHOXY 2,4,6 CYCLOHEPTATRIEN 1 ONE; 7 AZIDOMETHYL 4 ISOPROPYL 2 METHOXY 2,4,6 CYCLOHEPTATRIEN 1 ONE; ANTIOXIDANT; MORPHOLINE DERIVATIVE; N (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 2 CARBONYL) 4 (6 HYDROXY 4 ISOPROPYL 7 OXO 1,3,5 CYCLOHEPTATRIENMETHYL)PIPERAZINE; N (3,4 DIHYDRO 6 HYDROXY 2,5,7,8 TETRAMETHYL 2H 1 BENZOPYRAN 2 CARBONYL) 4 (6 HYDROXY 4 ISOPROPYL 7 OXO 1,3,5 CYCLOHEPTATRIENYLMETHYL) 1 PIPERAZINE ETHYLAMINE; NEUROPROTECTIVE AGENT; PIPERAZINE DERIVATIVE; THUJAPLICIN; TRIAZOLE DERIVATIVE; TROPOLONE; TROPOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL LINE; CONTROLLED STUDY; DRUG SYNTHESIS; HIPPOCAMPUS; IN VITRO STUDY; NERVE CELL; NEUROPROTECTION; OXIDATIVE STRESS;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL DEATH; CELL LINE; HIPPOCAMPUS; MOLECULAR STRUCTURE; MONOTERPENES; NEURONS; NEUROPROTECTIVE AGENTS; TROPOLONE;

EID: 75849135867     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.006     Document Type: Article

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