Interplay between the Smc5/6 complex and the Mph1 helicase in recombinational repair

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 50, 2009, Pages 21252-21257

  Chen, Yu Hung ^a,b   Choi, Koyi ^a,b   Szakal, Barnabas ^c   Arenz, Jacqueline ^a,e   Duan, Xinyuan ^d   Ye, Hong ^d   Branzei, Dana ^c   Zhao, Xiaolan ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^d University of Louisville School of Medicine   (United States)

^e UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HELICASE; PROTEIN; RECOMBINANT PROTEIN; STRUCTURAL MAINTENANCE OF CHROMOSOME 5; STRUCTURAL MAINTENANCE OF CHROMOSOME 6; UNCLASSIFIED DRUG;

ARTICLE; BUDDING; DNA DAMAGE; ENZYME ACTIVITY; GENE INTERACTION; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; YEAST;

CELL CYCLE PROTEINS; DEAD-BOX RNA HELICASES; DNA DAMAGE; DNA REPAIR; MUTANT PROTEINS; RECOMBINATION, GENETIC; RECQ HELICASES; SACCHAROMYCES CEREVISIAE PROTEINS; SACCHAROMYCETALES;

SACCHAROMYCETALES;

EID: 75849132866     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0908258106     Document Type: Article

References (36)

1. Zhao X, Blobel G (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci USA 102:4777-4782.
2. Sergeant J, et al. (2005) Composition and architecture of the Schizosaccharomyces pombe Rad18 (Smc5-6) complex. Mol Cell Biol 25:172-184.
3. Pebernard S, Wohlschlegel J, McDonald WH, Yates JR, III, Boddy MN (2006) The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex. Mol Cell Biol 26:1617-1630.
4. Taylor EM, Copsey AC, Hudson JJ, Vidot S, Lehmann AR (2008) Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Mol Cell Biol 28:1197-1206.
5. Palecek J, Vidot S, Feng M, Doherty AJ, Lehmann AR (2006) The Smc5-Smc6 DNA repair complex. Bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits. J Biol Chem 281:36952-36959.
6. Duan X, et al. (2009) The architecture of the Smc5/6 complex of S. cerevisiae reveals a unique interaction between the Nse5-6 subcomplex and the hinge regions of Smc5 and Smc6. J Biol Chem 284:8507-8515.
7. Andrews EA, et al. (2005) Nse2, a component of the Smc5-6 complex, is a SUMO ligase required for the response to DNA damage. Mol Cell Biol 25:185-196.
8. Potts PR, Yu H (2005) Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Mol Cell Biol 25:7021-7032.
9. Murray JM, Carr AM (2008) Smc5/6: A link between DNA repair and unidirectional replication? Nat Rev Mol Cell Biol 9:177-182.
10. De Piccoli G, Torres-Rosell J, Aragon L (2009) The unnamed complex: What do we know about Smc5-Smc6? Chromosome Res 17:251-263.
11. Branzei D, et al. (2006) Ubc9- and Mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks. Cell 127:509-522.
12. Sollier J, et al. (2009) The S. cerevisiae Esc2 and Smc5-6 proteins promote sister chromatid junction mediated intra-S repair. Mol Biol Cell 20:1671-1682.
13. Mankouri HW, Hickson ID (2007) The RecQ helicase-topoisomerase III-Rmi1 complex: ADNA structure-specific 'dissolvasome'? Trends Biochem Sci 32:538-546.
14. Liberi G, et al. (2005) Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase. Genes Dev 19:339-350.
15. Schurer KA, Rudolph C, Ulrich HD, Kramer W (2004) Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from homologous recombination, but not from postreplicative repair. Genetics 166:1673-1686.
16. St Onge RP, et al. (2007) Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat Genet 39:199-206.
17. Prakash R, et al. (2005) S. cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3′to 5′ DNA helicase. J Biol Chem 280:7854-7860.
18. Nishino T, Komori K, Tsuchiya D, Ishino Y, Morikawa K (2005) Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing. Structure (London) 13:143-153.
19. Meetei AR, et al. (2005) A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet 37:958-963.
20. Mosedale G, et al. (2005) The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway. Nature Structural and Molecular Biology 12:763-771.
21. Prakash R, et al. (2009) Yeast Mph1 helicase dissociates Rad51-made D-loops: Implications for crossover control in mitotic recombination. Genes Dev 23:67-79.
22. Sun W, et al. (2008) The FANCM ortholog Fml1 promotes recombination at stalled replication forks and limits crossing over during DNA double-strand break repair. Mol Cell 32:118-128.
23. Gari K, Decaillet C, Stasiak AZ, Stasiak A, Constantinou A (2008) The Fanconi anemia protein FANCM can promote branch migration of Holliday junctions and replication forks. Mol Cell 29:141-148.
24. Komori K, et al. (2004) Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of archaeal Hef protein in processing stalled replication forks. J Biol Chem 279:53175-53185.
25. Banerjee S, et al. (2008) Mph1p promotes gross chromosomal rearrangement through partial inhibition of homologous recombination. J Cell Biol 181:1083-1093.
26. Kang YH, et al. (2009) The MPH1 gene of S. cerevisiae functions in Okazaki fragments processing. J Biol Chem 284:10376-10386.
27. Onoda F, et al. (2004) SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in S. cerevisiae. DNA Repair 3:429-439.
28. Lindroos HB, et al. (2006) Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways. Mol Cell 22:755-767.
29. Lisby M, Barlow JH, Burgess RC, Rothstein R (2004) Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins. Cell 118:699-713.
30. Kitamura E, Blow JJ, Tanaka TU (2006) Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell 125:1297-1308.
31. Ira G, Malkova A, Liberi G, Foiani M, Haber JE (2003) Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell 115:401-411.
32. Lo YC, et al. (2006) Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity. Mol Cell Biol 26:4086-4094.
33. Robert T, Dervins D, Fabre F, Gangloff S (2006) Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover. EMBO J 25:2837-2846.
34. Mankouri HW, NgoHP, Hickson ID (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in S. cerevisiae. Mol Biol Cell 20:1683-1694.
35. Hoch NC, et al. (2008) Allelism of Saccharomyces cerevisiae gene PSO10, involved in error-prone repair of psoralen-induced DNA damage, with SUMO ligase-encoding MMS21. Curr Genet 53:361-371.
36. Straight AF, Belmont AS, Robinett CC, Murray AW (1996) GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion. Curr Biol 6:1599-1608.