메뉴 건너뛰기




Volumn 21, Issue 1, 2010, Pages 47-54

Involvement of stromal p53 in tumor-stroma interactions

Author keywords

Cancer; Cancer associated fibroblasts; p53; SDF 1; Stroma

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN P53;

EID: 75849129107     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2009.11.006     Document Type: Review
Times cited : (35)

References (54)
  • 1
    • 35148826938 scopus 로고    scopus 로고
    • Shaping genetic alterations in human cancer: the p53 mutation paradigm
    • Soussi T., and Wiman KG. Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell 12 (2007) 303-312
    • (2007) Cancer Cell , vol.12 , pp. 303-312
    • Soussi, T.1    Wiman KG2
  • 2
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael D., and Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 13 (2003) 49-58
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 3
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: the growing complexity of p53
    • Vousden K.H., and Prives C. Blinded by the light: the growing complexity of p53. Cell 137 (2009) 413-431
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 4
    • 70349442548 scopus 로고    scopus 로고
    • The first 30 years of p53: growing ever more complex
    • Levine A.J., and Oren M. The first 30 years of p53: growing ever more complex. Nat Rev Cancer 9 (2009) 749-758
    • (2009) Nat Rev Cancer , vol.9 , pp. 749-758
    • Levine, A.J.1    Oren, M.2
  • 5
    • 70349438905 scopus 로고    scopus 로고
    • The expanding universe of p53 targets
    • Menendez D., Inga A., and Resnick M.A. The expanding universe of p53 targets. Nat Rev Cancer 9 (2009) 724-737
    • (2009) Nat Rev Cancer , vol.9 , pp. 724-737
    • Menendez, D.1    Inga, A.2    Resnick, M.A.3
  • 6
  • 10
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Dameron K.M., Volpert O.V., Tainsky M.A., and Bouck N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science 265 (1994) 1582-1584
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 11
    • 0032902502 scopus 로고    scopus 로고
    • Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect
    • Nishizaki M., Fujiwara T., Tanida T., Hizuta A., Nishimori H., Tokino T., et al. Recombinant adenovirus expressing wild-type p53 is antiangiogenic: a proposed mechanism for bystander effect. Clin Cancer Res 5 (1999) 1015-1023
    • (1999) Clin Cancer Res , vol.5 , pp. 1015-1023
    • Nishizaki, M.1    Fujiwara, T.2    Tanida, T.3    Hizuta, A.4    Nishimori, H.5    Tokino, T.6
  • 12
    • 0032552020 scopus 로고    scopus 로고
    • p53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma
    • Holmgren L., Jackson G., and Arbiser J. p53 induces angiogenesis-restricted dormancy in a mouse fibrosarcoma. Oncogene 17 (1998) 819-824
    • (1998) Oncogene , vol.17 , pp. 819-824
    • Holmgren, L.1    Jackson, G.2    Arbiser, J.3
  • 13
    • 0042668356 scopus 로고    scopus 로고
    • Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth
    • Narendran A., Ganjavi H., Morson N., Connor A., Barlow J.W., Keystone E., et al. Mutant p53 in bone marrow stromal cells increases VEGF expression and supports leukemia cell growth. Exp Hematol 31 (2003) 693-701
    • (2003) Exp Hematol , vol.31 , pp. 693-701
    • Narendran, A.1    Ganjavi, H.2    Morson, N.3    Connor, A.4    Barlow, J.W.5    Keystone, E.6
  • 14
    • 67749118424 scopus 로고    scopus 로고
    • Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1
    • Kang S.Y., Halvorsen O.J., Gravdal K., Bhattacharya N., Lee J.M., Liu N.W., et al. Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1. Proc Natl Acad Sci USA 106 (2009) 12115-12120
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 12115-12120
    • Kang, S.Y.1    Halvorsen, O.J.2    Gravdal, K.3    Bhattacharya, N.4    Lee, J.M.5    Liu, N.W.6
  • 15
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan R.N., Riba R.D., Zacharoulis S., Bramley A.H., Vincent L., Costa C., et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438 (2005) 820-827
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3    Bramley, A.H.4    Vincent, L.5    Costa, C.6
  • 16
    • 0028849274 scopus 로고
    • Vogelstein B: p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • Waldman T., and Kinzler K.W. Vogelstein B: p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55 (1995) 5187-5190
    • (1995) Cancer Res , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2
  • 19
    • 0034602650 scopus 로고    scopus 로고
    • PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway
    • Tan M., Wang Y., Guan K., and Sun Y. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci USA 97 (2000) 109-114
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 109-114
    • Tan, M.1    Wang, Y.2    Guan, K.3    Sun, Y.4
  • 20
    • 0034096190 scopus 로고    scopus 로고
    • p53 regulates the expression of the tumor suppressor gene maspin
    • Zou Z., Gao C., Nagaich A.K., Connell T., Saito S., Moul J.W., et al. p53 regulates the expression of the tumor suppressor gene maspin. J Biol Chem 275 (2000) 6051-6054
    • (2000) J Biol Chem , vol.275 , pp. 6051-6054
    • Zou, Z.1    Gao, C.2    Nagaich, A.K.3    Connell, T.4    Saito, S.5    Moul, J.W.6
  • 21
    • 9844261161 scopus 로고    scopus 로고
    • A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis
    • Nishimori H., Shiratsuchi T., Urano T., Kimura Y., Kiyono K., Tatsumi K., et al. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene 15 (1997) 2145-2150
    • (1997) Oncogene , vol.15 , pp. 2145-2150
    • Nishimori, H.1    Shiratsuchi, T.2    Urano, T.3    Kimura, Y.4    Kiyono, K.5    Tatsumi, K.6
  • 22
    • 0035884402 scopus 로고    scopus 로고
    • Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma
    • Pal S., Datta K., and Mukhopadhyay D. Central role of p53 on regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in mammary carcinoma. Cancer Res 61 (2001) 6952-6957
    • (2001) Cancer Res , vol.61 , pp. 6952-6957
    • Pal, S.1    Datta, K.2    Mukhopadhyay, D.3
  • 23
    • 0028606364 scopus 로고
    • Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells
    • Ueba T., Nosaka T., Takahashi J.A., Shibata F., Florkiewicz R.Z., Vogelstein B., et al. Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. Proc Natl Acad Sci USA 91 (1994) 9009-9013
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9009-9013
    • Ueba, T.1    Nosaka, T.2    Takahashi, J.A.3    Shibata, F.4    Florkiewicz, R.Z.5    Vogelstein, B.6
  • 25
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
    • Ravi R., Mookerjee B., Bhujwalla Z.M., Sutter C.H., Artemov D., Zeng Q., et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14 (2000) 34-44
    • (2000) Genes Dev , vol.14 , pp. 34-44
    • Ravi, R.1    Mookerjee, B.2    Bhujwalla, Z.M.3    Sutter, C.H.4    Artemov, D.5    Zeng, Q.6
  • 26
    • 33845348208 scopus 로고    scopus 로고
    • p53 attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts
    • Moskovits N., Kalinkovich A., Bar J., Lapidot T., and Oren M. p53 attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Res 66 (2006) 10671-10676
    • (2006) Cancer Res , vol.66 , pp. 10671-10676
    • Moskovits, N.1    Kalinkovich, A.2    Bar, J.3    Lapidot, T.4    Oren, M.5
  • 27
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121 (2005) 335-348
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6
  • 28
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6 (2008) 2853-2868
    • (2008) PLoS Biol , vol.6 , pp. 2853-2868
    • Coppe, J.P.1    Patil, C.K.2    Rodier, F.3    Sun, Y.4    Munoz, D.P.5    Goldstein, J.6
  • 29
    • 0025775929 scopus 로고
    • Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product
    • Santhanam U., Ray A., and Sehgal P.B. Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product. Proc Natl Acad Sci USA 88 (1991) 7605-7609
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 7605-7609
    • Santhanam, U.1    Ray, A.2    Sehgal, P.B.3
  • 30
    • 0034646643 scopus 로고    scopus 로고
    • Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13)
    • Sun Y., Cheung J.M., Martel-Pelletier J., Pelletier J.P., Wenger L., Altman R.D., et al. Wild type and mutant p53 differentially regulate the gene expression of human collagenase-3 (hMMP-13). J Biol Chem 275 (2000) 11327-11332
    • (2000) J Biol Chem , vol.275 , pp. 11327-11332
    • Sun, Y.1    Cheung, J.M.2    Martel-Pelletier, J.3    Pelletier, J.P.4    Wenger, L.5    Altman, R.D.6
  • 31
    • 0033597213 scopus 로고    scopus 로고
    • p53 down-regulates human matrix metalloproteinase-1 (collagenase-1) gene expression
    • Sun Y., Wenger L., Rutter J.L., Brinckerhoff C.E., and Cheung H.S. p53 down-regulates human matrix metalloproteinase-1 (collagenase-1) gene expression. J Biol Chem 274 (1999) 11535-11540
    • (1999) J Biol Chem , vol.274 , pp. 11535-11540
    • Sun, Y.1    Wenger, L.2    Rutter, J.L.3    Brinckerhoff, C.E.4    Cheung, H.S.5
  • 32
    • 15244360282 scopus 로고    scopus 로고
    • P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex
    • Sun Y., Zeng X.R., Wenger L., Firestein G.S., and Cheung H.S. P53 down-regulates matrix metalloproteinase-1 by targeting the communications between AP-1 and the basal transcription complex. J Cell Biochem 92 (2004) 258-269
    • (2004) J Cell Biochem , vol.92 , pp. 258-269
    • Sun, Y.1    Zeng, X.R.2    Wenger, L.3    Firestein, G.S.4    Cheung, H.S.5
  • 33
    • 0030826510 scopus 로고    scopus 로고
    • Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter
    • Bian J., and Sun Y. Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter. Mol Cell Biol 17 (1997) 6330-6338
    • (1997) Mol Cell Biol , vol.17 , pp. 6330-6338
    • Bian, J.1    Sun, Y.2
  • 34
    • 28944432805 scopus 로고    scopus 로고
    • Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis
    • Hill R., Song Y., Cardiff R.D., and Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 123 (2005) 1001-1011
    • (2005) Cell , vol.123 , pp. 1001-1011
    • Hill, R.1    Song, Y.2    Cardiff, R.D.3    Van Dyke, T.4
  • 38
    • 47049117155 scopus 로고    scopus 로고
    • P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy
    • Lafkas D., Trimis G., Papavassiliou A.G., and Kiaris H. P53 mutations in stromal fibroblasts sensitize tumors against chemotherapy. Int J Cancer 123 (2008) 967-971
    • (2008) Int J Cancer , vol.123 , pp. 967-971
    • Lafkas, D.1    Trimis, G.2    Papavassiliou, A.G.3    Kiaris, H.4
  • 39
    • 33750364739 scopus 로고    scopus 로고
    • Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice
    • Burdelya L.G., Komarova E.A., Hill J.E., Browder T., Tararova N.D., Mavrakis L., et al. Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice. Cancer Res 66 (2006) 9356-9361
    • (2006) Cancer Res , vol.66 , pp. 9356-9361
    • Burdelya, L.G.1    Komarova, E.A.2    Hill, J.E.3    Browder, T.4    Tararova, N.D.5    Mavrakis, L.6
  • 40
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T., Butterfield C.E., Kraling B.M., Shi B., Marshall B., O'Reilly M.S., et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 60 (2000) 1878-1886
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3    Shi, B.4    Marshall, B.5    O'Reilly, M.S.6
  • 41
    • 0029814061 scopus 로고    scopus 로고
    • Anti-apoptotic activity of low levels of wild-type p53
    • Lassus P., Ferlin M., Piette J., and Hibner U. Anti-apoptotic activity of low levels of wild-type p53. EMBO J 15 (1996) 4566-4573
    • (1996) EMBO J , vol.15 , pp. 4566-4573
    • Lassus, P.1    Ferlin, M.2    Piette, J.3    Hibner, U.4
  • 42
    • 0033836606 scopus 로고    scopus 로고
    • The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis
    • McKay B.C., Chen F., Perumalswami C.R., Zhang F., and Ljungman M. The tumor suppressor p53 can both stimulate and inhibit ultraviolet light-induced apoptosis. Mol Biol Cell 11 (2000) 2543-2551
    • (2000) Mol Biol Cell , vol.11 , pp. 2543-2551
    • McKay, B.C.1    Chen, F.2    Perumalswami, C.R.3    Zhang, F.4    Ljungman, M.5
  • 43
    • 0034612236 scopus 로고    scopus 로고
    • Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1
    • Zhang Y., Griffith E.C., Sage J., Jacks T., and Liu J.O. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proc Natl Acad Sci USA 97 (2000) 6427-6432
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6427-6432
    • Zhang, Y.1    Griffith, E.C.2    Sage, J.3    Jacks, T.4    Liu, J.O.5
  • 44
    • 46349108651 scopus 로고    scopus 로고
    • Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine
    • Dudley A.C., Shih S.C., Cliffe A.R., Hida K., and Klagsbrun M. Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer 99 (2008) 118-125
    • (2008) Br J Cancer , vol.99 , pp. 118-125
    • Dudley, A.C.1    Shih, S.C.2    Cliffe, A.R.3    Hida, K.4    Klagsbrun, M.5
  • 45
    • 0035153878 scopus 로고    scopus 로고
    • Presence of genetic alterations in microdissected stroma of human colon and breast cancers
    • Wernert N., Locherbach C., Wellmann A., Behrens P., and Hugel A. Presence of genetic alterations in microdissected stroma of human colon and breast cancers. Anticancer Res 21 (2001) 2259-2264
    • (2001) Anticancer Res , vol.21 , pp. 2259-2264
    • Wernert, N.1    Locherbach, C.2    Wellmann, A.3    Behrens, P.4    Hugel, A.5
  • 46
    • 0036843937 scopus 로고    scopus 로고
    • Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
    • Kurose K., Gilley K., Matsumoto S., Watson P.H., Zhou X.P., and Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 32 (2002) 355-357
    • (2002) Nat Genet , vol.32 , pp. 355-357
    • Kurose, K.1    Gilley, K.2    Matsumoto, S.3    Watson, P.H.4    Zhou, X.P.5    Eng, C.6
  • 47
    • 34248564820 scopus 로고    scopus 로고
    • Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma
    • Fukino K., Shen L., Patocs A., Mutter G.L., and Eng C. Genomic instability within tumor stroma and clinicopathological characteristics of sporadic primary invasive breast carcinoma. JAMA 297 (2007) 2103-2111
    • (2007) JAMA , vol.297 , pp. 2103-2111
    • Fukino, K.1    Shen, L.2    Patocs, A.3    Mutter, G.L.4    Eng, C.5
  • 48
    • 37349101054 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations and nodal metastases
    • Patocs A., Zhang L., Xu Y., Weber F., Caldes T., Mutter G.L., et al. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 357 (2007) 2543-2551
    • (2007) N Engl J Med , vol.357 , pp. 2543-2551
    • Patocs, A.1    Zhang, L.2    Xu, Y.3    Weber, F.4    Caldes, T.5    Mutter, G.L.6
  • 49
    • 71049116818 scopus 로고    scopus 로고
    • p53 expression in tumor stromal fibroblasts is associated with the outcome of patients with invasive ductal carcinoma of the breast
    • Hasebe T., Okada N., Tamura N., Houjoh T., Akashi-Tanaka S., Tsuda H., et al. p53 expression in tumor stromal fibroblasts is associated with the outcome of patients with invasive ductal carcinoma of the breast. Cancer Sci 100 (2009) 2101-2108
    • (2009) Cancer Sci , vol.100 , pp. 2101-2108
    • Hasebe, T.1    Okada, N.2    Tamura, N.3    Houjoh, T.4    Akashi-Tanaka, S.5    Tsuda, H.6
  • 50
    • 42349091268 scopus 로고    scopus 로고
    • Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes
    • Hawsawi N.M., Ghebeh H., Hendrayani S.F., Tulbah A., Al-Eid M., Al-Tweigeri T., et al. Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes. Cancer Res 68 (2008) 2717-2725
    • (2008) Cancer Res , vol.68 , pp. 2717-2725
    • Hawsawi, N.M.1    Ghebeh, H.2    Hendrayani, S.F.3    Tulbah, A.4    Al-Eid, M.5    Al-Tweigeri, T.6
  • 51
    • 70149088171 scopus 로고    scopus 로고
    • Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution
    • [Discussion 6769]
    • Campbell I., Polyak K., and Haviv I. Clonal mutations in the cancer-associated fibroblasts: the case against genetic coevolution. Cancer Res 69 (2009) 6765-6768 [Discussion 6769]
    • (2009) Cancer Res , vol.69 , pp. 6765-6768
    • Campbell, I.1    Polyak, K.2    Haviv, I.3
  • 52
    • 42049091225 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations
    • [Author reply 1636]
    • Campbell I.G., Qiu W., Polyak K., and Haviv I. Breast-cancer stromal cells with TP53 mutations. N Engl J Med 358 (2008) 1634-1635 [Author reply 1636]
    • (2008) N Engl J Med , vol.358 , pp. 1634-1635
    • Campbell, I.G.1    Qiu, W.2    Polyak, K.3    Haviv, I.4
  • 53
    • 42549152045 scopus 로고    scopus 로고
    • No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
    • Qiu W., Hu M., Sridhar A., Opeskin K., Fox S., Shipitsin M., et al. No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet 40 (2008) 650-655
    • (2008) Nat Genet , vol.40 , pp. 650-655
    • Qiu, W.1    Hu, M.2    Sridhar, A.3    Opeskin, K.4    Fox, S.5    Shipitsin, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.