Synthesis and antitumor activity of new dihydropyridine thioglycosides and their corresponding dehydrogenated forms

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 973-982

  Abbas, Hebat Allah S ^a   El Sayed, Wael A ^a   Fathy, Nahed M ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

1,4 Dihydropyridine thioglycosides; Antitumor activity; Piperidinium salts; Pyridine thioglycosides

Indexed keywords

2 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 (1' THIO BETA DEXTRO GALACTOPYRANOSYL) 1,4 DIHDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 (1' THIO BETA DEXTRO GALACTOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 (1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GALACTOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GALACTOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 METHOXYPHENYL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 NAPHTHALEN 2 YL) 6 (1' THIO BETA DEXTRO GALACTOPYRANOSYL) 1,4 DIHDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (4 NITROPHENYL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (NAPHTHALEN 2 YL) 6 (1' THIO BETA DEXTRO GALACTOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 (NAPHTHALEN 2 YL) 6 (1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (NAPHTHALEN 2 YL) 6 (1' THIO BETA DEXTRO GLUCOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 (NAPHTHALEN 2 YL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GALACTOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 (NAPHTHALEN 2 YL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GALACTOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 (NAPHTHALEN 2 YL) 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GLUCOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 PHENYL 6 (1' THIO BETA DEXTRO GALACTOPYRANOSYL) 1,4 DIHDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 PHENYL 6 (1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 PHENYL 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GALACTOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 3,5 DICYANO 4 PHENYL 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GALACTOPYRANOSYL)PYRIDINE; 2 AMINO 3,5 DICYANO 4 PHENYL 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 4 (4 BROMOPHENYL) 3,5 DICYANO 6 (1' THIO BETA DEXTRO GLUCOPYRANOSYL)PYRIDINE; 2 AMINO 4 (4 BROMOPHENYL) 3,5 DICYANO 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GLUCOPYRANOSYL) 1,4 DIHYDROPYRIDINE; 2 AMINO 4 (4 BROMOPHENYL) 3,5 DICYANO 6 (2',3',4',6' TETRA O ACETYL 1' THIO BETA DEXTRO GLUCOPYRANOSYL)PYRIDINE; CISPLATIN; DIHYDROPYRIDINE; THIOGLYCOSIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DEHYDROGENATION; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LD 50; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DIHYDROPYRIDINES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROGENATION; MALE; MICE; MOLECULAR STRUCTURE; NEOPLASMS; THIOGLYCOSIDES;

EID: 75849126291     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.11.039     Document Type: Article

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