Semi-synthetic aristolactams-inhibitors of CDK2 enzyme

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 4, 2010, Pages 1384-1387

  Hegde, Vinod R ^a   Borges, Scott ^a   Pu, Haiyan ^a   Patel, Mahesh ^a   Gullo, Vincent P ^a   Wu, Bonnie ^a   Kirschmeier, Paul ^a   Williams, Michael J ^a   Madison, Vincent ^a   Fischmann, Thierry ^a   Chan, Tze Ming ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Aristolactams; IC50; SAR; Semi synthetic analogs

Indexed keywords

ARISTOLOLACTAM; CYCLIN DEPENDENT KINASE 2;

ARTICLE; CELL STRAIN MCF 7; DRUG STRUCTURE; HUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ARISTOLOCHIC ACIDS; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZOLES; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75849124104     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.007     Document Type: Article

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