Methotrexate: Understanding the risk in psoriasis patients

Journal of Dermatological Treatment

Volumn 20, Issue 5, 2009, Pages 311-313

  Lucas, Jennifer ^a   Ntuen, Edidiong ^a   Pearce, Daniel J ^a   Fleischer Jr , Alan B ^a   Feldman, Steven R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; METFORMIN; METHOTREXATE;

ADULT; AMINOTRANSFERASE BLOOD LEVEL; BLOOD CELL COUNT; BONE MARROW SUPPRESSION; DISEASE SEVERITY; DRUG EFFICACY; DRUG FATALITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; INFECTION; INTERSTITIAL PNEUMONIA; KIDNEY FAILURE; LACTIC ACIDOSIS; LETTER; LIVER CIRRHOSIS; LIVER FAILURE; LIVER FIBROSIS; LYMPHOMA; MALE; MORBIDITY; MORTALITY; PANCYTOPENIA; PATIENT EDUCATION; PNEUMONIA; PRIORITY JOURNAL; PSORIASIS; PSORIATIC ARTHRITIS; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; SIDE EFFECT; TOXIC EPIDERMAL NECROLYSIS;

DERMATOLOGIC AGENTS; HUMANS; METHOTREXATE; PSORIASIS; RISK ASSESSMENT;

EID: 75849122809     PISSN: 09546634     EISSN: 14711753     Source Type: Journal    
DOI: 10.1080/09546630902877931     Document Type: Letter

References (65)

1. Collins P, Rogers S. The efficacy of methotrexate in psoriasis - A review of 40 cases. Clin Exp Dermatol. 1992;17:257-60.
2. Haustein UF, Rytter M. Methotrexate in psoriasis: 26 years' experience with low-dose long-term treatment. J Eur Acad Dermatol Venereol. 2000;14:382-8.
3. Kremer JM. Methotrexate update. Scand J Rheumatol. 1996;25:341-4.
4. Salaffi F, Manganelli P, Carotti M, Subiaco S, Lamanna G, Cervini C. Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: Report of five cases and review of the literature. Clin Rheumatol. 1997;16:296-304.
5. Mazokopakis E, Katsogridakis K, Koutsopoulos A, Voloudaki A, Froudarakis M, Kritikos H, et al. Fatal methotrexate-induced pneumonitis in a psoriatic patient. Mil Med. 2004;169:298-300.
6. Clerc D, Brousse C, Mariette X, Bennet P, Bisson M. Cytomegalovirus pneumonia in a patient with rheumatoid arthritis treated with low dose methotrexate and prednisone. Ann Rheum Dis. 1991;50:67.
7. Lemense GP, Sahn SA. Opportunistic infection during treatment with low dose methotrexate. Am J Respir Crit Care Med. 1994;150:258-60.
8. Berthelot JM, Maugars Y, Hamidou M, Chiffoleau A, Barrier J, Grolleau JY, et al. Pancytopenia and severe cytopenia induced by low-dose methotrexate. Eight case-reports and a review of one hundred cases from the literature (with twenty-four deaths). Rev Rhum Engl Ed 1995;62:(7-8):477-86.
9. Ostor AJ, O'Gradaigh DR, Jenner JR. Methotrexate for rheumatoid arthritis: What should the patient be told? Rheumatology (Oxford). 2003;42:1576-8.
10. Szanto E. Low-dose methotrexate treatment of rheumatoid arthritis; long-term observation of efficacy and safety. Clin Rheumatol. 1989;8:323-30.
11. Mariette X, Cazals-hatem D, Warszawki J, Liote F, Balandraud N, Sibilia J. Lymphomas in rheumatoid arthritis patients treated with methotrexate: A 3-year prospective study in France. Blood. 2002;99:3909-15.
12. Sosin M, Handa S. Low dose methotrexate and bone marrow suppression. BMJ. 2003;326:266-7.
13. Thaler SJ, Bailey EM. Case 14 - 1996 - A 66-year-old woman with toxic epidermal necrolysis and a fatal course. N Engl J Med. 1996;334:1254-61.
14. Gutierrez-Urena S, Molina JF, Garcia CO, Cuellar ML, Espinoza LR. Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis. Arthritis Rheum. 1996;39:272-6.
15. Kremer JM, Alarcon GS, Weinblatt ME, Kaymakcian MV, Macaluso M, Cannon GW, et al. Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: A multicenter study with literature review. Arthritis Rheum. 1997;40:1829-37.
16. Mayall B, Poggi G, Parkin JD. Neutropenia due to low-dose methotrexate therapy for psoriasis and rheumatoid arthritis may be fatal. Med J Aust. 1991;155:480-4.
17. Buchbinder R, Hall S, Sambrook PN, Champion GD, Harkness A, Lewis D, et al. Methotrexate therapy in rheumatoid arthritis: A life table review of 587 patients treated in community practice. J Rheumatol. 1993;20:639-44.
18. Krebs S, Gibbons RB. Low-dose methotrexate as a risk factor for Pneumocystis carinii pneumonia. Mil Med. 1996;161:58-60.
19. Zachariae H, Sogaard H, Heickendorff L. Methotrexate-induced liver cirrhosis. Clinical, histological and serological studies - a further 10-year follow-up. Dermatology. 1996;192:343-6.
20. Vallerand H, Cossart C, Milosevic D, Lavaud F, Leone J. Fatal pneumocystis pneumonia in asthmatic patient treated with methotrexate. Lancet. 1992;339:1551.
21. Al-Awadhi A, Dale P, Mckendry RJ. Pancytopenia associated with low dose methotrexate therapy. A regional survey. J Rheumatol. 1993;20:1121-5.
22. Wallace JR, Luchi M. Fatal cytomegalovirus pneumonia in a patient receiving corticosteroids and methotrexate for mixed connective tissue disease. South med J. 1996;89:726-8.
23. Omdal R, Goransson L, Bergrem H. Fatal outcome of low-dose methotrexate therapy in rheumatoid arthritis. Clin Rheumatol. 1993;12:283-4.
24. Myllykangas-Luosujarvi R, Aho K, Isomaki H. Death attributed to antirheumatic medication in a nationwide series of 1666 patients with rheumatoid arthritis who have died. J Rheumatol. 1995;22:2214-17.
25. Bedrossian CW, Miller WC, Luna MA. Methotrexate-induced diffuse interstitial pulmonary fibrosis. South Med J. 1979;72:313-18.
26. Imokawa S, Colby TV, Leslie KO, Helmers RA. Methotrexate pneumonitis: Review of the literature and histopathological findings in nine patients. Eur Respir J. 2000;15:373-81.
27. Van der Veen MJ, Dekker JJ, Dinant HJ, van Soesbergen RM, Bijlsma JW. Fatal pulmonary fibrosis complicating low dose methotrexate therapy for rheumatoid arthritis. J Rheumatol. 1995;22:1766-8.
28. Sweet JM, Holstege CP. Bone marrow failure from medication error: Diagnosis by history, not biopsy. Arch Intern Med. 2001;161:1911-12.
29. Mckenna KE, Burrows D. Pulmonary toxicity in a patient with psoriasis receiving methotrexate therapy. Clin Exp Dermatol. 2000;25:24-7.
30. Sostman HD, Matthay RA, Putman CE, Smith GJ. Methotrexate-induced pneumonitis. Medicine (Baltimore). 1976;55:371-88.
31. Hilliquin P, Renoux M, Perrot S, Puechal X, Menkes CJ. Occurrence of pulmonary complications during methotrexate therapy in rheumatoid arthritis. Br J Rheumatol. 1996;35:441-5.
32. Gispen JG, Alarcon GS, Johnson JJ, Acton RT, Barger BO, Koopman WJ. Toxicity of methotrexate in rheumatoid arthritis. J Rheumatol. 1987;14:74-9.
33. MacKinnon SK, Starkebaum G, Willkens RF. Pancytopenia associated with low dose pulse methotrexate in the treatment of rheumatoid arthritis. Semin Arthritis Rheum. 1985;15:119-26.
34. Stenger AA, Houtman PM, Bruyn GA, Eggink HF, Pasma HR. Pneumocystis carinii pneumonia associated with low dose methotrexate treatment for rheumatoid arthritis. Scand J Rheumatol. 1994;23:51-3.
35. Scully CJ, Anderson CJ, Cannon GW. Long-term methotrexate therapy for rheumatoid arthritis. Semin Arthritis Rheum. 1991;20:317-31.
36. Shiroky JB, Frost A, Skelton JD, Haegert DG, Newkirk MM, Neville C. Complications of immunosuppression associated with weekly low dose methotrexate. J Rheumatol. 1991;18:1172-5.
37. Kevat SG, Hill WR, Mccarthy PJ, Ahern MJ. Pancytopenia induced by low-dose methotrexate for rheumatoid arthritis. Aust N Z J Med. 1988;18:697-700.
38. Kremer JM. Safety, efficacy, and mortality in a long-term cohort of patients with rheumatoid arthritis taking methotrexate: Follow up after a mean of 13.3 years. Arthritis Rheum. 1997;40:984-5.
39. Cornelissen JJ, Bakker LJ, Van der Veen MJ, Rozenberg-Arska M, Bijlsma JW. Nocardia asteroides pneumonia complicating low dose methotrexate treatment of refractory rheumatoid arthritis. Ann Rheum Dis. 1991;50:642-4.
40. St Clair EW, Rice Jr, Synderman R. Pneumonitis complicating low-dose methotrexate therapy in rheumatoid arthritis. Arch Intern Med. 1985;145:2035-8.
41. Newman ED, Harrington TM. Fatal methotrexate pneumonitis in rheumatoid arthritis. Arthritis Rheum. 1988;31:1585-6.
42. Arnett FC, Whelton JC, Zizic TM, Stevens MB. Methotrexate therapy in polymyositis. Ann Rheum Dis. 1973;32:536-46.
43. Kohler S, Neumann J, Durk H, Saal J, Muller GA. [Pancytopenia during low-dose oral methotrexate therapy of psoriatic arthritis.] Dtsch med. Wochenschr. 1989;114:1286-8.
44. Wyss E, Kuhn M, Luzi HP, Reinhart WH. [Fatal outcome of pneumocystis-carinii pneumonia under low-dose methotrexate and prednisone therapy for chronic rheumatoid arthritis. Case report and literature review.] Schweiz Rundsch Med Prax. 1994;83:449-52.
45. Bruyn GA, Essed CE, Houtman PM, Willemse FW. Fatal cardiac nodules in a patient with rheumatoid arthritis treated with low dose methotrexate. J Rheumatol. 1993;20:912-14.
46. Sharma A, Provenzale D, Mckusick A, Kaplan MM. Interstitial pneumonitis after low-dose methotrexate therapy in primary biliary cirrhosis. Gastroenterology. 1994;107:266-70.
47. Roux N, Flipo RM, Cortet B, Lafitte JJ, Tonnel AB, Duquesnoy B, et al. Pneumocystis carinii pneumonia in rheumatoid arthritis patients treated with methotrexate. A report of two cases. Rev Rhum Engl Ed. 1996;63:453-6.
48. Elsasser S, Dalquen P, Soler M, Perruchoud AP. Methotrexate-induced pneumonitis: Appearance four weeks after discontinuation of treatment. Am Rev Respir Dis. 1989;140:1089-92.
49. Roth PE, Grosshans E, Bergoend H. [Psoriasis: Development and fatal complications.] Ann Dermatol. Venereol. 1991;118:97-105.
50. Doolittle GC, Simpson KM, Lindsley HB. Methotrexate-associated, early-onset pancytopenia in rheumatoid arthritis. Arch Intern Med. 1989;149:1430-1.
51. Flood DA, Chan CK, Pruzanski W. Pneumocystis carinii pneumonia associated with methotrexate therapy in rheumatoid arthritis. J Rheumatol. 1991;18:1254-6.
52. Wollner A, Mohle-boetani J, Lambert RE, Perruquet JL, Raffin TA, Mcguire JL. Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis. Thorax. 1991;46:205-7.
53. Bell MJ, Geddie WR, Gordon DA, Reynolds WJ. Pre-existing lung disease in patients with rheumatoid arthritis may predispose to methotrexate lung. Arthritis Rheum. 1987;29:S75.
54. Matsushima H, Takayanagi N, Kawata I, Sakamoto T, Motegi M, Ubukata M, et al. [Two fatal cases of methotrexate-induced interstitial pneumonitis.] Nihon Kokyuki Gakkai. Zasshi. 2002;40:249-55.
55. Jeurissen ME, Boerbooms AM, van de Putte LB. Pancytopenia and methotrexate with trimethoprim-sulfamethoxazole. Ann Intern Med. 1989;111:261.
56. Shupack JL, Webster GF. Pancytopenia following low-dose oral methotrexate therapy for psoriasis. JAMA. 1988;259:3594-6.
57. Kazlow DW, Federgrun D, Kurtin S, Lebwohl MG. Cutaneous ulceration caused by methotrexate. J Am Acad Dermatol. 2003;49:(2 suppl case reports):S197-8.
58. Landewe RB, van den Borne BE, Breedveld FC, Dijkmans BA. Methotrexate effects in patients with rheumatoid arthritis with cardiovascular comorbidity. Lancet. 2000;355:1616-17.
59. Bologna C, Picot MC, Jorgensen C, Viu P, Verdier R, Sany J. Study of eight cases of cancer in 426 rheumatoid arthritis patients treated with methotrexate. Ann Rheum Dis. 1997;56:97-102.
60. Ebeo CT, Girish MR, Byrd RP, Roy TM, Mehta JB. Methotrexate-induced pulmonary lymphoma. Chest. 2003;123:2150-3.
61. Cleary AG, McDowell H, Sills JA. Polyarticular juvenile idiopathic arthritis treated with methotrexate complicated by the development of non-Hodgkin's lymphoma. Arch Dis Child. 2002;86:47-9.
62. Baird RD, van Zyl-Smit RN, Dilke T, Scott SE., Rassam SM. Spontaneous remission of low-grade B-cell non-Hodgkin's lymphoma following withdrawal of methotrexate in a patient with rheumatoid arthritis: Case report and review of the literature. Br J Haematol. 2002;118:567-8.
63. Tang H, Neuberger J. Review article: Methotrexate in gastroenterology - dangerous villain or simply misunderstood? Aliment Pharmacol Ther. 1996;10:851-8.
64. Psoriasis-liver-methotrexate interactions. Arch Dermatol. 1973;108:36-42.
65. Yeoh S, Siderov J. Methotrexate misadventure: A case for counseling. Rheumatology (Oxford). 2001;40:230-2.