메뉴 건너뛰기




Volumn 71, Issue 1, 2010, Pages 115-119

Evaluation of the safety of spinosad and milbemycin 5-oxime orally administered to Collies with the MDR1 gene mutation

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; AVERMECTIN; IVERMECTIN; MILBEMYCIN; MILBEMYCIN 5 OXIME; MILBEMYCIN DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN 1; PLACEBO; SPINOSAD; UNCLASSIFIED DRUG;

EID: 75749150897     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.71.1.115     Document Type: Article
Times cited : (23)

References (30)
  • 1
    • 0020563596 scopus 로고
    • Adverse reactions to unapproved applications (lett)
    • Preston JM. Adverse reactions to unapproved applications (lett). Vet Rec 1983;112:286.
    • (1983) Vet Rec , vol.112 , pp. 286
    • Preston, J.M.1
  • 2
    • 4143098211 scopus 로고    scopus 로고
    • Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the Collie lineage
    • Neff MW, Robertson KR, Wong AK, et al. Breed distribution and history of canine mdr1-1Δ, a pharmacogenetic mutation that marks the emergence of breeds from the Collie lineage. Proc Natl Acad Sci U S A 2004;101:11725-11730.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 11725-11730
    • Neff, M.W.1    Robertson, K.R.2    Wong, A.K.3
  • 3
    • 0025901077 scopus 로고
    • Assessment of toxicosis induced by high-dose administration of milbemycin oxime in Collies
    • Tranquilli WJ, Paul AJ, Todd KS. Assessment of toxicosis induced by high-dose administration of milbemycin oxime in Collies. Am J Vet Res 1991;52:1170-1172.
    • (1991) Am J Vet Res , vol.52 , pp. 1170-1172
    • Tranquilli, W.J.1    Paul, A.J.2    Todd, K.S.3
  • 4
    • 75749124200 scopus 로고    scopus 로고
    • Bayer Animal Health. Companion animal products. Important risk information. Available at: www.bayer-ah.com/products.cfm#. Acessed Sep 21, 2009.
    • Bayer Animal Health. Companion animal products. Important risk information. Available at: www.bayer-ah.com/products.cfm#. Acessed Sep 21, 2009.
  • 5
    • 21244452361 scopus 로고    scopus 로고
    • Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein
    • Griffin J, Fletcher N, Clemence R, et al. Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein. J Vet Pharmacol Ther 2005;28:257-265.
    • (2005) J Vet Pharmacol Ther , vol.28 , pp. 257-265
    • Griffin, J.1    Fletcher, N.2    Clemence, R.3
  • 6
    • 0003043023 scopus 로고
    • Safety of ivermectin in target animals
    • Campbell WC, ed, New York: Springer-Verlag
    • Pulliam JD, Preston JM. Safety of ivermectin in target animals. In: Campbell WC, ed. Ivermectin and abamectin. New York: Springer-Verlag, 1989;149-161.
    • (1989) Ivermectin and abamectin , pp. 149-161
    • Pulliam, J.D.1    Preston, J.M.2
  • 7
    • 0023323838 scopus 로고
    • Clinical observations in Collies given ivermectin orally
    • Paul AJ, Tranquilli WJ, Seward RL, et al. Clinical observations in Collies given ivermectin orally. Am J Vet Res 1987;48:684-685.
    • (1987) Am J Vet Res , vol.48 , pp. 684-685
    • Paul, A.J.1    Tranquilli, W.J.2    Seward, R.L.3
  • 8
    • 0038143305 scopus 로고    scopus 로고
    • Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies
    • Nelson OL, Carsten E, Bentjen SA, et al. Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies. J Vet Intern Med 2003;17:354-356.
    • (2003) J Vet Intern Med , vol.17 , pp. 354-356
    • Nelson, O.L.1    Carsten, E.2    Bentjen, S.A.3
  • 9
    • 32844470268 scopus 로고    scopus 로고
    • Adverse drug reactions in herding breeds
    • Mealey KL. Adverse drug reactions in herding breeds. Compend Contin Educ Pract Vet 2006;28:23-33.
    • (2006) Compend Contin Educ Pract Vet , vol.28 , pp. 23-33
    • Mealey, K.L.1
  • 10
    • 0001810813 scopus 로고
    • Toxicology
    • Campbell WC, ed, New York: Springer-Verlag
    • Lankas GR, Gordon LR. Toxicology. In: Campbell WC, ed. Ivermectin and abamectin. New York: Springer-Verlag, 1989;89-112.
    • (1989) Ivermectin and abamectin , pp. 89-112
    • Lankas, G.R.1    Gordon, L.R.2
  • 11
    • 0025884667 scopus 로고
    • Modulation of monomethylhydrazine-induced seizures by ivermectin
    • Mayer TW, Horton ML. Modulation of monomethylhydrazine-induced seizures by ivermectin. Toxicol Lett 1991;57:167-173.
    • (1991) Toxicol Lett , vol.57 , pp. 167-173
    • Mayer, T.W.1    Horton, M.L.2
  • 12
    • 0035164622 scopus 로고    scopus 로고
    • Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene
    • Mealey KL, Bentjen SA, Gay JM, et al. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001;11:727-733.
    • (2001) Pharmacogenetics , vol.11 , pp. 727-733
    • Mealey, K.L.1    Bentjen, S.A.2    Gay, J.M.3
  • 13
    • 0242523974 scopus 로고    scopus 로고
    • Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity
    • Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J Am Vet Med Assoc 2003;223:1453-1455.
    • (2003) J Am Vet Med Assoc , vol.223 , pp. 1453-1455
    • Mealey, K.L.1    Northrup, N.C.2    Bentjen, S.A.3
  • 14
    • 0033980182 scopus 로고    scopus 로고
    • P-glycoprotein: A defense mechanism limiting oral bioavailability and CNS accumulation of drugs
    • Fromm MF. P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int J Clin Pharmacol Ther 2000;38:69-74.
    • (2000) Int J Clin Pharmacol Ther , vol.38 , pp. 69-74
    • Fromm, M.F.1
  • 15
    • 0033514320 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine
    • Fromm MF, Kim RB, Stein CM, et al. Inhibition of P-glycoprotein-mediated drug transport: a unifying mechanism to explain the interaction between digoxin and quinidine. Circulation 1999;99:552-557.
    • (1999) Circulation , vol.99 , pp. 552-557
    • Fromm, M.F.1    Kim, R.B.2    Stein, C.M.3
  • 17
    • 33846559746 scopus 로고    scopus 로고
    • Pharmacogenetics: It's not just about ivermectin in Collies
    • Dowling P. Pharmacogenetics: it's not just about ivermectin in Collies. Can Vet J 2006;47:1165-1168.
    • (2006) Can Vet J , vol.47 , pp. 1165-1168
    • Dowling, P.1
  • 18
    • 0013095102 scopus 로고    scopus 로고
    • MDR1 genotype-related pharmacokinetics and pharmacodynamics
    • Sakaeda T, Nakamura T, Okumura K. MDR1 genotype-related pharmacokinetics and pharmacodynamics. Biol Pharm Bull 2002;25:1391-1400.
    • (2002) Biol Pharm Bull , vol.25 , pp. 1391-1400
    • Sakaeda, T.1    Nakamura, T.2    Okumura, K.3
  • 19
    • 36248938694 scopus 로고    scopus 로고
    • Preliminary studies on the effectiveness of die novel pulicide, spinosad, for the treatment and control of fleas on dogs
    • Snyder DE, Meyer J, Zimmermann AG, et al. Preliminary studies on the effectiveness of die novel pulicide, spinosad, for the treatment and control of fleas on dogs. Vet Parasitol 2007;150:345-351.
    • (2007) Vet Parasitol , vol.150 , pp. 345-351
    • Snyder, D.E.1    Meyer, J.2    Zimmermann, A.G.3
  • 20
    • 42149187577 scopus 로고    scopus 로고
    • Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs
    • Robertson-Plouch C, Baker KA, Hozak R, et al. Clinical field study of the safety and efficacy of spinosad chewable tablets for controlling fleas on dogs. Vet Ther 2008;9:26-36.
    • (2008) Vet Ther , vol.9 , pp. 26-36
    • Robertson-Plouch, C.1    Baker, K.A.2    Hozak, R.3
  • 21
    • 0025917476 scopus 로고
    • A83543A-D, unique fermentation derived tetracyclic macrolides
    • Kirst HA, Michel KH, Martin JW, et al. A83543A-D, unique fermentation derived tetracyclic macrolides. Tetrahedron Lett 1991;32:4839-4842.
    • (1991) Tetrahedron Lett , vol.32 , pp. 4839-4842
    • Kirst, H.A.1    Michel, K.H.2    Martin, J.W.3
  • 22
    • 0031878248 scopus 로고    scopus 로고
    • Studies on the mode of action of spinosad: Insect symptoms and physiological correlates
    • Salgado VL. Studies on the mode of action of spinosad: insect symptoms and physiological correlates. Pestic Biochem Physiol 1998;60:91-102.
    • (1998) Pestic Biochem Physiol , vol.60 , pp. 91-102
    • Salgado, V.L.1
  • 23
    • 0034765781 scopus 로고    scopus 로고
    • Natural products as insecticides: The biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids
    • Sparks TC, Crouse GD, Durst G. Natural products as insecticides: the biology, biochemistry and quantitative structure-activity relationships of spinosyns and spinosoids. Pest Manag Sci 2001;57:896-905.
    • (2001) Pest Manag Sci , vol.57 , pp. 896-905
    • Sparks, T.C.1    Crouse, G.D.2    Durst, G.3
  • 24
    • 75749084765 scopus 로고    scopus 로고
    • US FDA, Freedom of Information Summary. Comfortis. Available at:, Accessed Mar 9,2008
    • US FDA. Center for Veterinary Medicine Web site. Freedom of Information Summary. Comfortis. Available at: www.fda.gov/cvm/FOl/141-277o092507.pdf. Accessed Mar 9,2008.
    • Center for Veterinary Medicine Web site
  • 25
    • 75749091120 scopus 로고    scopus 로고
    • Available at:, Accessed Mar 9, 2008
    • Comfortis™ (spinosad) chewable tablets. Available at: www.comfortis4dogs.com/-layouts/downloads/comfortis-product-labeLpdf. Accessed Mar 9, 2008.
    • Comfortis™ (spinosad) chewable tablets
  • 26
    • 75749102925 scopus 로고    scopus 로고
    • Veterinary International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products VICH, Target animal safety, pharmaceuticals. VICH GL 43. Brussels: VICH, 1998
    • Veterinary International Cooperation on Harmonization of Technical Requirements for Registration of Veterinary Medicinal Products (VICH). (Target animal safety) - pharmaceuticals. VICH GL 43. Brussels: VICH, 1998.
  • 27
    • 0003633755 scopus 로고    scopus 로고
    • National Research Council, Washington, DC: National Academy Press
    • National Research Council. Guide for the care and use of laboratory animals. Washington, DC: National Academy Press, 1996.
    • (1996) Guide for the care and use of laboratory animals
  • 28
    • 0026320161 scopus 로고
    • Evaluation of the safety of ivermectin administered in a beef-based formulation to ivermectin-sensitive Collies
    • Fassler PE, Tranquilli WJ, Paul AJ, et al. Evaluation of the safety of ivermectin administered in a beef-based formulation to ivermectin-sensitive Collies. J Am Vet Med Assoc 1991;199:457-460.
    • (1991) J Am Vet Med Assoc , vol.199 , pp. 457-460
    • Fassler, P.E.1    Tranquilli, W.J.2    Paul, A.J.3
  • 29
    • 1542725067 scopus 로고    scopus 로고
    • Effects of dermal application of 10.0% imidacloprid-0.08% ivermectin in ivermectin-sensitive Collies
    • Paul AJ, Hutchens DE, Firkins LD, et al. Effects of dermal application of 10.0% imidacloprid-0.08% ivermectin in ivermectin-sensitive Collies. Am J Vet Res 2004;65:277-278.
    • (2004) Am J Vet Res , vol.65 , pp. 277-278
    • Paul, A.J.1    Hutchens, D.E.2    Firkins, L.D.3
  • 30
    • 75749135202 scopus 로고    scopus 로고
    • US FDA Center for Veterinary Medicine, Available at:, Accessed Nov 11, 2008
    • US FDA Center for Veterinary Medicine. COMFORTIS® and ivermectin interaction safety warning notification. Available at: www.fda.gov/ AnimalVeterinary/NewsEvents/CVMUpdates/ucm047942.htm. Accessed Nov 11, 2008.
    • COMFORTIS® and ivermectin interaction safety warning notification


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.