Pharmacogenetics: It's not just about ivermectin in collies;Pharmacogénétique: Au-delà de l'ivermectin et des colleys

Canadian Veterinary Journal

Volumn 47, Issue 12, 2006, Pages 1165-1168

  Dowling, Patricia ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; BUTORPHANOL; CORTICOSTEROID; CYCLOSPORIN; CYTOCHROME P450 3A; DIGOXIN; DOXORUBICIN; DOXYCYCLINE; ERYTHROMYCIN; GLYCOPROTEIN P; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; IMMUNOSUPPRESSIVE AGENT; ITRACONAZOLE; IVERMECTIN; KETOCONAZOLE; LOPERAMIDE; MITOXANTRONE; MORPHINE; MOXIDECTIN; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; PHENOTHIAZINE DERIVATIVE; PHENYTOIN; RIFAMPICIN; SELAMECTIN; TETRACYCLINE; UNINDEXED DRUG; VINBLASTINE; VINCRISTINE;

ARTICLE; BLOOD BRAIN BARRIER; DOG DISEASE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG EXCRETION; DRUG METABOLISM; DRUG POTENTIATION; DRUG TRANSPORT; FRAMESHIFT MUTATION; GASTROINTESTINAL TRACT; GENE DELETION; GENOTYPE; NEUROTOXICITY; NONHUMAN; PHARMACOGENETICS; PROTEIN EXPRESSION;

ANIMALS; BLOOD-BRAIN BARRIER; DOG DISEASES; DOGS; GENES, MDR; P-GLYCOPROTEIN; PEDIGREE; PHARMACOGENETICS; SPECIES SPECIFICITY; VETERINARY DRUGS;

EID: 33846559746     PISSN: 00085286     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Schinkel AH, Smit JJ, van Tellingen O, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994;77:491-502.
2. Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001;11:727-733.
3. Mealey KL. Therapeutic implications of the MDR-1 gene. J Vet Pharmacol Ther 2004;27:257-264.
4. Henik RA, Kellum HB, Bentjen SA, Mealey KL. Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation. J Vet Intern Med 2006;20:415-417.
5. Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J Am Vet Med Assoc 2003;223:1453-1455, 1434,
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7. Neff MW, Robertson KR, Wong AK, et al. Breed distribution and history of canine mdr1-1 Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage. Proc Natl Acad Sci USA 2004;101:11725-11730.