Elevation of myostatin and FOXOs in prolonged muscular impairment induced by eccentric contractions in rat medial gastrocnemius muscle

Journal of Applied Physiology

Volumn 108, Issue 2, 2010, Pages 306-313

  Ochi, Eisuke ^a,b   Hirose, Tatsuro ^b   Hiranuma, Kenji ^b   Min, Seok Ki ^b   Ishii, Naokata ^c   Nakazato, Koichi ^b  

^a MEIJI GAKUIN UNIVERSITY   (Japan)

^b NIPPON SPORT SCIENCE UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Atrophy related protein; Hypertrophy; Protein metabolism; Recovery; Speed

Indexed keywords

ACTIVIN RECEPTOR 2; ACTIVIN RECEPTOR TYPE II B; ACTIVIN RECEPTOR TYPE II-B; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, RAT; FOXO3A PROTEIN, RAT; MUSCLE PROTEIN; MYOSTATIN; NERVE PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; ATROPHY; BIOMECHANICS; BIOSYNTHESIS; BODY WEIGHT; HYPERTROPHY; JOINT; MALE; METABOLISM; MUSCLE CONTRACTION; MUSCLE ISOMETRIC CONTRACTION; ORGAN SIZE; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; WESTERN BLOTTING; WISTAR RAT;

ACTIVIN RECEPTORS, TYPE II; ANIMALS; ATROPHY; BIOMECHANICS; BLOTTING, WESTERN; BODY WEIGHT; FORKHEAD TRANSCRIPTION FACTORS; HYPERTROPHY; ISOMETRIC CONTRACTION; JOINTS; MALE; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOSTATIN; NERVE TISSUE PROTEINS; ORGAN SIZE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 75749134139     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00278.2009     Document Type: Article

References (45)

1. Allen DL, Unterman TG. Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors. Am J Physiol Cell Physiol 292: C188-C199, 2007.
2. Amirouche A, Durieux AC, Banzet S, Koulmann N, Bonnefoy R, Mouret C, Bigard X, Peinnequin A, Freyssenet D. Down-regulation of Akt/mammalian target of rapamycin signaling pathway in response to myostatin overexpression in skeletal muscle. Endocrinology 150: 286-294, 2009.
3. Baar K, Esser K. Phosphorylation of p70(S6k) correlates with increased skeletal muscle mass following resistance exercise. Am J Physiol Cell Physiol 276: Cl20-C127, 1999.
4. Best TM, McCabe RP, Corr D, Vanderby R, Jr. Evaluation of a new method to create a standardized muscle stretch injury. Med Sci Sports Exerc 30: 200-205, 1998. (Pubitemid 28095933)
5. Bodine SC, Stitt TN, Gonzalez M, Kline WO, Stover GL, Bauerlein R, Zlotchenko E, Scrimgeour A, Lawrence JC, Glass DJ, Yancopoulos GD. Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol 3: 10141019, 2001. (Pubitemid 34428747)
6. Bolster DR, Kubica N, Crozier SJ, Williamson DL, Farrell PA, Kimball SR, Jefferson LS. Immediate response of mammalian target of rapamycin (mTOR)-mediated signalling following acute resistance exercise in rat skeletal, muscle. J Physiol 553: 213-220, 2003. (Pubitemid 37483929)
7. Brooks SV, Zerba E, Faulkner JA. Injury to muscle fibres after single stretches of passive and maximally stimulated muscles in. mice. J Physiol 488: 459-469, 1995.
8. Chapman D, Newton M, Sacco P, Nosaka K. Greater muscle damage induced by fast versus slow velocity eccentric exercise. Int J Sports Med 27: 591-598, 2006. (Pubitemid 44221067)
9. Chapman DW, Newton M, McGuigan M, Nosaka K. Effect of lengthening contraction velocity on muscle damage of the elbow flexors. Med Sci Sports Exerc 40: 926-933, 2008.
10. Clarkson PM, Nosaka K, Braun B. Muscle function after exerciseinduced muscle damage and rapid adaptation. Med Sci Sports Exerc 24: 512-520, 1992.
11. Creer A, Gallagher P, Slivka D, Jemiolo B, Fink W, Trappe S. Influence of muscle glycogen availability on ERK1/2 and Akt signaling after resistance exercise in human skeletal, muscle. J Appl Physiol 99: 950-956, 2005. (Pubitemid 41214508)
12. Farthing JP, Chilibeck PD. The effects of eccentric and concentric training at different velocities on muscle hypertrophy. Eur J Appl Physiol 89: 578-586, 2003. (Pubitemid 37080733)
13. FridenJ.Changesinhumanskeletal,muscleinducedbylong-term, eccentricexercise.CellTissueRes236:365-372,1984.(Pubitemid14143341)
14. FridenJ.Musclesorenessafterexercise:implicationsofmorphologicalchanges. IntJSportsMed5:57-66,1984.(Pubitemid14100681)
15. Glass DJ. Molecular mechanisms modulating muscle mass. Trends Mol Med 9: 344-350, 2003. (Pubitemid 37040030)
16. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci USA 98: 14440-14445, 2001. (Pubitemid 33121410)
17. Greer EL, Brunet A. FOXO transcription factors in ageing and cancer. Acta Physiol (Oxf) 192: 19-28, 2008. (Pubitemid 350284502)
18. Hammers DW, Merritt EK, Matheny W, Adamo ML, Walters TJ, Estep JS, Farrar RP. Functional, deficits and insulin-like growth factor-I gene expression following tourniquet-induced injury of skeletal muscle in young and old rats. J Appl Physiol 105: 1274-1281, 2008.
19. Hasselman CT, Best TM, Seaber AV, Garrett WE, Jr. A threshold and continuum of injury during active stretch of rabbit skeletal muscle. Am J Sports Med 23: 65-73, 1995.
20. Higbie EJ, Cureton KJ, Warren GL, 3rd, Prior BM. Effects of concentric and eccentric training on muscle strength, cross-sectional, area, and neural, activation. J Appl Physiol 81: 2173-2181, 1996.
21. HortobagyiT,BarrierJ,BeardD,BraspennincxJ,KoensP,DevitaP,DempseyL, LambertJ.Greaterinitial,adaptations- submaximalmusclelengtheningthanmaximalshortening.JApplPhysiol81:1677-1682,1996. (Pubitemid26349625)
22. Jackman RW, Kandarian SC. The molecular basis of skeletal muscle atrophy. Am J Physiol Cell Physiol 287: C834-C843, 2004. (Pubitemid 39238306)
23. Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O. Skeletal muscle FOXOl. (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem 279: 41114-41123, 2004. (Pubitemid 39287713)
24. Kandarian SC, Jackman RW. Intracellular signaling during skeletal muscle atrophy. Muscle Nerve 33: 155-165, 2006. (Pubitemid 43208671)
25. Kellis E, Baltzopoulos V. Isokinetic eccentric exercise. Sports Med 19: 202-222, 1995.
26. Louis E, Raue U, Yang Y, Jemiolo B, Trappe S. Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol 103: 1744-1751, 2007. (Pubitemid 350033861)
27. Maclntyre DL, Sorichter S, Mair J, Berg A, McKenzie DC. Markers of inflammation and myofibrillar proteins following eccentric exercise in humans. Eur J Appl Physiol 84: 180-186, 2001. (Pubitemid 32229391)
28. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6: 458-471, 2007. (Pubitemid 350163055)
29. McCullyKK,FaulknerJA.Injury- skeletalmusclefibersofmicefollowinglengtheningcontractions.JApplPhysiol59: 119-126,1985.(Pubitemid15230302)
30. McKay BR, O'Reilly CE, Phillips SM, Tarnopolsky MA, Parise G. Co-expression of IGF-1. family members with myogenic regulatory factors following acute damaging muscle-lengthening contractions in humans. J Physiol 586: 5549-5560, 2008.
31. Naito T, Goto K, Morioka S, Matsuba Y, Akema T, Sugiura T, Ohira Y, Beppu M, Yoshioka T. Administration of granulocyte colony-stimulating factor facilitates the regenerative process of injured mice skeletal muscle via the activation of Akt/GSK3αβ signals. Eur J Appl Physiol 105: 643-651, 2009.
32. Nedergaard A, Vissing K, Overgaard K, Kjaer M, Schjerling P. Expression patterns of atrogenic and ubiquitin proteasome component genes with exercise: effect of different loading patterns and repeated exercise bouts. J Appl Physiol 103: 1513-1522, 2007. (Pubitemid 350033833)
33. Nosaka K, Clarkson PM. Muscle damage following repeated bouts of high force eccentric exercise. Med Sci Sports Exerc 27: 1263-1269, 1995.
34. Ochi E, Nakazato K, Ishii N. Effects of eccentric exercise on joint stiffness and muscle connectin (titin) isoform in the rat hindlimb. J Physiol Sci 57: 1.-6, 2007. (Pubitemid 46974935)
35. Okada A, Ono Y, Nagatomi R, Kishimoto KN, Itoi E. Decreased muscle atrophy F-box (MAFbx) expression in regenerating muscle after muscle-damaging exercise. Muscle Nerve 38: 1246-1253, 2008.
36. Pardo PS, Lopez MA, Boriek AM. FOXO transcription factors are mechanosensitive and their regulation is altered with aging in the respiratory pump. Am. J Physiol Cell Physiol 294: C1056-Cl066, 2008.
37. Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD, Glass DJ. Mediation of IGF-1 -induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol 3: 1009-1013, 2001. (Pubitemid 34428746)
38. SakamotoK,AschenbachWG,HirshmanMF,GoodyearLJ. Aktsignalinginskeletalmuscle:regulationbyexerciseandpassivestretch. AmJPhysiolEndocrinolMetab285:E1081-E1088,2003.(Pubitemid37296330)
39. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117: 399-412, 2004. (Pubitemid 38534545)
40. Shepstone TN, Tang JE, Dallaire S, Schuenke MD, Staron RS, Phillips SM. Short-term, high- vs. low-velocity isokinetic lengthening training results in greater hypertrophy of the elbow flexors in young men. J Appl Physiol 98: 1768-1776, 2005. (Pubitemid 40570788)
41. Song H, Nakazato K, Nakajima H. Effect of increased excursion of the ankle on the severity of acute eccentric contraction-induced strain injury in the gastrocnemius: an in vivo rat study. Am J Sports Med 32: 1263-1269, 2004. (Pubitemid 38970382)
42. Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ. The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 14: 395-403, 2004. (Pubitemid 38591410)
43. Thomas M, Langley B, Berry C, Sharma M, Kirk S, Bass J, Kambadur R. Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J Biol Chem 275: 40235-40243, 2000. (Pubitemid 32064654)
44. Tsuchida K, Nakatani M, Uezumi A, Murakami T, Cui X. Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer. Endocr J 55: 11-21, 2008.
45. WarrenGL,HayesDA,LoweDA,ArmstrongRB. Mechanicalfactorsintheinitiationofeccentriccontraction- inducedinjuryinratsoleusmuscle.JPhysiol464:457-475,1993.(Pubitemid23169326)