Upregulation of AQP3 and AQP5 induced by dexamethasone and ambroxol in A549 cells

Respiratory Physiology and Neurobiology

Volumn 161, Issue 2, 2008, Pages 111-118

  Ben, Yong ^a   Chen, Jie ^a   Zhu, Rong ^a   Gao, Lei ^a   Bai, Chunxue ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

A549 cells; Ambroxol; Aquaporins; Dexamethasone

Indexed keywords

AMBROXOL; AQUAPORIN 1; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 5; DEXAMETHASONE; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECOMMENDED DRUG DOSE; RESPIRATORY EPITHELIUM; UPREGULATION;

ADENOCARCINOMA; AMBROXOL; AQUAPORIN 1; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 5; DEXAMETHASONE; EPITHELIAL CELLS; EXPECTORANTS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; RESPIRATORY MUCOSA; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 42249086437     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2007.12.007     Document Type: Article

References (24)

1. Agre P., King L.S., Yasui M., Guggino W.B., Ottersen O.P., Fujiyoshi Y., Engel A., and Nielsen S. Aquaporin water channels-from atomic structure to clinical medicine. J. Physiol. 542 (2002) 3-16
2. Bai C., Fukuda N., Song Y., Ma T., Matthay M.A., and Verkman A.S. Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. J. Clin. Invest. 103 (1999) 555-561
3. Borok Z., Lubman R.L., Danto S.I., Zhang X.L., Zabski S.M., King L.S., Lee D.M., Agre E.D., and Crandall P. Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin 5. Am. J. Respir. Cell Mol. Biol. 18 (1998) 554-561
4. Effros R.M., Darin C., Jacobs E.R., Rogers R.A., Krenz G., and Schneeberger E.E. Water transport and distribution of aquaporin-1 in the pulmonary airspaces. J. Appl. Physiol. 83 (1997) 1002-1016
5. Folkesson H.G., Matthay M.A., Hasegawa H., Kheradmand F., and Verkman A.S. Transcellular water transport in lung alveolar epithelium through mercury-sensitive water channels. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 4970-4974
6. Frigeri A., Gropper M., Turck C.W., and Verkman A.S. Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 4328-4331
7. Funaki H., Yamamoto F.H., Koyama Y., Kondo D., Yaoita E., Kawasaki K., Kobayashi H., Sawaguchi S., Abe H., and Kihara I. Localization and expression of AQP5 in cornea, serous salivary glands, and pulmonary epithelial cells. Am. J. Physiol. Cell Physiol. 275 (1998) C1151-C1157
8. Germouty J., and Jirou-Najou J.L. Clinical efficacy of ambroxol in the treatment of bronchial stasis. Clinical trial in 120 patients at two different doses. Respiration 51 Suppl. 1 (1987) 37-41
9. Gibbs B.F., Schmutzler W., Vollrath I.B., Brosthardt P., Braam U., Wolff H.H., and Zwadlo-Klarwasser G. Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm. Res. 48 (1999) 86-93
10. Gillissen A., Bartling A., Schoen S., and Schultze-Werninghaus G. Antioxidant function of ambroxol in mononuclear and polymorphonuclear cells in vitro. Lung 175 (1997) 235-242
11. King L.S., Nielsen S., and Agre P. Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. J. Clin. Invest. 97 (1996) 2183-2191
12. King L.S., Nielsen S., and Agre P. Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat. Am. J. Physiol. Cell Physiol. 273 (1997) C1541-C1548
13. Kreda S.M., Gynn M.C., and Fenstermacher D.A. Expression and localization of epithelial aquaporins in the adult human lung. Am. J. Respir. Cell Mol. Biol. 24 (2001) 224-234
14. Nielsen S., Smith B.L., Christensen E.I., and Agre P. Distribution of the aquaporin CHIP in secretory and resorptive epithelia and capillary endothelia. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 7275-7279
15. Nielsen S., King L.S., Christensen B.M., and Agre P. Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. Am. J. Physiol. Cell Physiol. 273 (1997) C1549-C1561
16. Pfeifer S., Zissel G., Kienast K., and Muller-Quernheim J. Reduction of cytokine release of blood and bronchoalveolar mononuclear cells by ambroxol. Eur. J. Med. Res. 2 (1997) 129-132
17. Schmalisch G., Wauer R.R., and Bohme B. Effect of early ambroxol treatment on lung functions in mechanically ventilated preterm newborns who subsequently developed a bronchopulmonary dysplasia (BPD). Respir. Med. 94 (2000) 378-384
18. Schnitzer J.E., and Oh P. Aquaporin-1 in plasma membrane and caveolae provide mercury-sensitive water channels across lung endothelium. Am. J. Physiol. Heart Circ. Physiol. 270 (1996) H416-H422
19. Song Y., Yang B., Matthay M.A., Ma T., and Verkman A.S. Role of aquaporin water channels in pleural fluid dynamics. Am. J. Physiol. Cell Physiol. 279 (2000) C1744-C1750
20. Suzuki M., Teramoto S., Matsuse T., Ohga E., Katayama H., and Fukuchi Y. Inhibitory effect of ambroxol on superoxide anion production and generation by murine lung alveolar macrophages. J. Asthma 35 (1998) 267-272
21. Tanaka M., Inase N., Fushimi K., Ishibashi K., Ichioka M., Sasaki S., and Marumo F. Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line. Am. J. Physiol. 273 (1997) L1090-L1095
22. Tsang K.W., Leung J.C., Tipoe G.L., Leung R., Yan C., Ooi G.C., Chan H.H., Lam W.K., and Lai K.N. Down-regulation of aquaporin 3 in bronchiectatic airways in vivo. Respir. Med. 97 (2003) 59-64
23. Wauer R.R., Schmalisch G., Bohme B., Arand J., and Lehmann D. Randomized double blind trial of ambroxol for the treatment of respiratory distress syndrome. Eur. J. Pediatr. 151 (1992) 357-363
24. Yasui M. Molecular mechanisms and drug development in aquaporin water channel diseases: structure and function of aquaporins. J. Pharmacol. Sci. 96 (2004) 260-263