-
1
-
-
31444434449
-
mTOR signaling: Implications for cancer and anticancer therapy
-
Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N. mTOR signaling: implications for cancer and anticancer therapy. Br J Cancer 2006; 94:195-9.
-
(2006)
Br J Cancer
, vol.94
, pp. 195-199
-
-
Petroulakis, E.1
Mamane, Y.2
Le Bacquer, O.3
Shahbazian, D.4
Sonenberg, N.5
-
2
-
-
34548052424
-
Translation matters: Protein synthesis defects in inherited disease
-
Scheper GC, van der Knaap MS, Proud CG. Translation matters: protein synthesis defects in inherited disease. Nat Rev Genet 2007; 8:711-23.
-
(2007)
Nat Rev Genet
, vol.8
, pp. 711-723
-
-
Scheper, G.C.1
van der Knaap, M.S.2
Proud, C.G.3
-
3
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009; 10:307-18.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
4
-
-
0035990924
-
Inhibition of protein kinase B/Akt. implications for cancer therapy
-
Hill MM, Hemmings BA. Inhibition of protein kinase B/Akt. implications for cancer therapy. Pharmacol Ther 2002; 93:243-51.
-
(2002)
Pharmacol Ther
, vol.93
, pp. 243-251
-
-
Hill, M.M.1
Hemmings, B.A.2
-
5
-
-
0036185848
-
The protein kinase B/ Akt signalling pathway in human malignancy
-
Nicholson KM, Anderson NG. The protein kinase B/ Akt signalling pathway in human malignancy. Cell Signal 2002; 14:381-95.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
6
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001; 98:10983-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
7
-
-
0019870366
-
New antitumor substances of natural origin
-
Douros J, Suffness M. New antitumor substances of natural origin. Cancer Treat Rev 1981; 8:63-87.
-
(1981)
Cancer Treat Rev
, vol.8
, pp. 63-87
-
-
Douros, J.1
Suffness, M.2
-
9
-
-
65549167833
-
Targeting the mTOR signaling network for cancer therapy
-
Meric-Bernstam F, Gonzalez-Angulo AM. Targeting the mTOR signaling network for cancer therapy. J Clin Oncol 2009; 27:2278-87.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2278-2287
-
-
Meric-Bernstam, F.1
Gonzalez-Angulo, A.M.2
-
10
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356:2271-81.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
-
11
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372:449-56.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
-
12
-
-
75749105837
-
Inhibition of mammalian target of rapamycin as a therapeutic strategy in the management of bladder cancer
-
Mansure JJ, Nassim R, Chevalier S, Rocha J, Scarlata E, Kassouf W. Inhibition of mammalian target of rapamycin as a therapeutic strategy in the management of bladder cancer. Cancer Biol Ther 2009; 8:2339-47.
-
(2009)
Cancer Biol Ther
, vol.8
, pp. 2339-2347
-
-
Mansure, J.J.1
Nassim, R.2
Chevalier, S.3
Rocha, J.4
Scarlata, E.5
Kassouf, W.6
-
13
-
-
62549099008
-
The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
-
Trinh XB, Tjalma WA, Vermeulen PB, Van den Eynden G, Van der Auwera I, Van Laere SJ, et al. The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer. Br J Cancer 2009; 100:971-8.
-
(2009)
Br J Cancer
, vol.100
, pp. 971-978
-
-
Trinh, X.B.1
Tjalma, W.A.2
Vermeulen, P.B.3
Van den Eynden, G.4
Van der Auwera, I.5
Van Laere, S.J.6
-
14
-
-
70350100969
-
Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma
-
Gasperini P, Tosato G. Targeting the mammalian target of Rapamycin to inhibit VEGF and cytokines for the treatment of primary effusion lymphoma. Leukemia 2009; 23:1867-74.
-
(2009)
Leukemia
, vol.23
, pp. 1867-1874
-
-
Gasperini, P.1
Tosato, G.2
-
15
-
-
63849239484
-
Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells
-
Bohm A, Aichberger KJ, Mayerhofer M, Herrmann H, Florian S, Krauth MT, et al. Targeting of mTOR is associated with decreased growth and decreased VEGF expression in acute myeloid leukaemia cells. Eur J Clin Invest 2009; 39:395-405.
-
(2009)
Eur J Clin Invest
, vol.39
, pp. 395-405
-
-
Bohm, A.1
Aichberger, K.J.2
Mayerhofer, M.3
Herrmann, H.4
Florian, S.5
Krauth, M.T.6
-
16
-
-
70349379206
-
Phase I/II trial of CCI 779 and bevacizumab in advanced renal cell carcinoma (RCC): Safety and activity in RTKI refractory RCC patients
-
Merchan JR, Pitot HC, Qin R, Liu G, Fitch TR, Picus J, et al. Phase I/II trial of CCI 779 and bevacizumab in advanced renal cell carcinoma (RCC): Safety and activity in RTKI refractory RCC patients. J Clin Oncol 2009; 27:15.
-
(2009)
J Clin Oncol
, vol.27
, pp. 15
-
-
Merchan, J.R.1
Pitot, H.C.2
Qin, R.3
Liu, G.4
Fitch, T.R.5
Picus, J.6
-
17
-
-
67749122122
-
Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
-
Engelman JA. Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 2009; 9:550-62.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 550-562
-
-
Engelman, J.A.1
-
18
-
-
33750068623
-
mTOR, translation initiation and cancer
-
Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. mTOR, translation initiation and cancer. Oncogene 2006; 25:6416-22.
-
(2006)
Oncogene
, vol.25
, pp. 6416-6422
-
-
Mamane, Y.1
Petroulakis, E.2
LeBacquer, O.3
Sonenberg, N.4
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